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ABSTRACT Context Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have been detected with increasing frequency as a result of the progression of diagnostic modalities. Recently, invasive ductal carcinoma of the pancreas concomitant with IPMNs has been the focus of attention. Case report We report the case of a 57-year-old man with multifocal ductal carcinomas of the pancreas concomitant with IPMNs detected by intraoperative cytology. During a follow-up for branch duct IPMNs, a stenotic lesion of the main duct in the pancreatic body was found by ERCP, and brush cytology of the stenosis revealed an adenocarcinoma. A distal pancreatectomy was proposed; however, intraoperative pancreatic juice cytology from the pancreatic head also revealed adenocarcinoma, and a total pancreatectomy was finally carried out. Pathological examination of the resected specimen showed multifocal ductal carcinomas and IPMNs in the distal pancreas, and invasive ductal carcinoma in the pancreatic head which had not been detected by preoperative imaging studies. Conclusions Surgeons should be aware of the possibility of multifocal carcinomas in patients with concomitant IPMNs. Intraoperative pancreatic juice cytology should always be performed in order to confirm the absence of carcinoma in the pancreas to be left in place after planned resection

COMPUTER ANALYSIS OF A SLIP MOTION OF A SCREW. DISLOCATION IN A BCC LATTICE

Slip motion of a screw dislocation in a bee lattice under shear stress was simulated and analyzed using an atomicrow potential (two dimensional calculation) and Johnson potential (three dimensional calculation) for three typical direction of shearing, i.e., x=-30° (twinning direction), x=0°and x=30°(anti-twinning direction). In the case of an inter-atomicrow potential yield stresses were obtained as 3 × 10＾＜-3＞, 4 × 10＾＜-3 ＞and 28×10^＜-3＞μ for the above three directions, respectively (=O) and 23×l0＾＜-3＞, 21×10＾＜－3＞ and 26×l0＾＜-3＞μ for =0.1. Slip planes obtained in these calculations were twinning (112) plane, except the antitwinning stressing in a=0.1, where (101) slip was activated. For these two types of potentials metastable configurations at half an atomic distance were not obtained and the stable1. Introduction / 2. Computation Procedure / 3. Results / 4. Discussio

尿中タイチンの上昇は、急性期脳卒中の転帰と関連する

Introduction: Urinary titin is a biomarker of muscle atrophy, which is a serious complication after stroke. However, there are currently no clinical data regarding urinary titin in stroke patients. Methods: Consecutive stroke patients admitted to the stroke care unit were included. Spot urine samples were collected immediately after admission, and on days 3, 5, and 7. The primary outcome was the trend of urinary titin in patients after acute stroke. The secondary outcomes included the association between the peak urinary titin level and the modified Rankin Scale (mRS) score, the National Institutes of Health Stroke Scale (NIHSS) score, and the Barthel index (BI) upon hospital discharge. Multivariate analysis was adjusted for age, sex, NIHSS at admission, and the peak urinary titin to predict poor outcome (mRS 3–6). Results: Forty-one patients were included (29 male; age, 68±15 years), 29 had ischemic stroke, 8 had intracerebral hemorrhage, and 4 had subarachnoid hemorrhage. The levels of urinary titin on days 1, 3, 5, and 7 were 9.9 (4.7–21.1), 16.2 (8.6–22.0), 8.9 (4.8–15.2), and 8.7 (3.6–16.2) pmol/mg Cr, respectively. The peak urinary titin level was associated with the mRS score (r = 0.55, p < 0.01), the NIHSS score (r = 0.72, p < 0.01), and the BI (r = –0.59, p < 0.01) upon hospital discharge. In multivariate analysis, the peak urinary titin was associated with poor outcome (p = 0.03). Conclusions: Urinary titin rapidly increased after stroke and was associated with impaired functional outcomes at hospital discharge

Multifocal Pancreatic Ductal Adenocarcinomas Concomitant with Intraductal Papillary Mucinous Neoplasms of the Pancreas Detected by Intraoperative Pancreatic Juice Cytology. A Case Report

Context Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have been detected with increasing frequency as a result of the progression of diagnostic modalities. Recently, invasive ductal carcinoma of the pancreas concomitant with IPMNs has been the focus of attention. Case report We report the case of a 57-year-old man with multifocal ductal carcinomas of the pancreas concomitant with IPMNs detected by intraoperative cytology. During a follow-up for branch duct IPMNs, a stenotic lesion of the main duct in the pancreatic body was found by ERCP, and brush cytology of the stenosis revealed an adenocarcinoma. A distal pancreatectomy was proposed; however, intraoperative pancreatic juice cytology from the pancreatic head also revealed adenocarcinoma, and a total pancreatectomy was finally carried out. Pathological examination of the resected specimen showed multifocal ductal carcinomas and IPMNs in the distal pancreas, and invasive ductal carcinoma in the pancreatic head which had not been detected by preoperative imaging studies. Conclusions Surgeons should be aware of the possibility of multifocal carcinomas in patients with concomitant IPMNs. Intraoperative pancreatic juice cytology should always be performed in order to confirm the absence of carcinoma in the pancreas to be left in place after planned resection.Image: Schematic representation of the location of IPMNs and non-invasive and invasive ductal carcinomas

Computer Simulation of Defects in Molybdenum Using Finnis-Sinclair Potential

Structure of self-interstitial atoms（SIA）and a screw dislocation in molybdenum have been studied by computer simulation using Finnis-Sinclair potential. It was found that formation energy for <110> dumbbell is 4.44 eV and that for <111> crowdion is almost same or slightly higher than this value. A screw dislocation has a lowest energy for polarized type and other types of core structure were not observed. A SIA has a <111> crowdion structure in a screw dislocation core, and the interaction energy between a screw dislocation and a <111> crowdion is 3.6 eV