770 research outputs found
Strain-Compensated AlInGaAs-GaAsP Superlattices for Highly-Polarized Electron Emission
Spin-polarized electron emission from the first superlattice photocathodes
developed with strain compensation is investigated. An opposite strain in the
quantum well and barrier layers is complished using an InAlGaAs/GaAsP
superlattice structure. The measured values of maximum polarization and quantum
yield for the structure with a 0.18 um-thick working layer are close to the
best results reported for any strained superlattice photocathode structure,
demonstrating the high potential of strain compensation for future photocathode
applications. An analysis of the photoemission spectra is used to estimate the
parameters responsible for the polarization losses.Comment: 10 pages, 2 figure
Stress Cardiomyopathy (Takotsubo Cardiomyopathy)
In this article we describe a rare clinical condition of stress cardiomyopathy (takotsubo cardiomyopathy) for which we, despite controversy and lack of data, identified the main pathogenic pathways (including the direct toxic effect of catecholamines on the myocardium, catecholamine-mediated myocardial stunning, and microcirculation disorders). After the systematic review, we identified the distinct pathology features of this condition and new diagnostic strategies
The current status of orbital experiments for UHECR studies
Two types of orbital detectors of extreme energy cosmic rays are being
developed nowadays: (i) TUS and KLYPVE with reflecting optical systems
(mirrors) and (ii) JEM-EUSO with high-transmittance Fresnel lenses. They will
cover much larger areas than existing ground-based arrays and almost uniformly
monitor the celestial sphere. The TUS detector is the pioneering mission
developed in SINP MSU in cooperation with several Russian and foreign
institutions. It has relatively small field of view (+/-4.5 deg), which
corresponds to a ground area of 6.4x10^3 sq.km. The telescope consists of a
Fresnel-type mirror-concentrator (~2 sq.m) and a photo receiver (a matrix of
16x16 photomultiplier tubes). It is to be deployed on the Lomonosov satellite,
and is currently at the final stage of preflight tests. Recently, SINP MSU
began the KLYPVE project to be installed on board of the Russian segment of the
ISS. The optical system of this detector contains a larger primary mirror (10
sq.m), which allows decreasing the energy threshold. The total effective field
of view will be at least +/-14 degrees to exceed the annual exposure of the
existing ground-based experiments. Several configurations of the detector are
being currently considered. Finally, JEM-EUSO is a wide field of view (+/-30
deg) detector. The optics is composed of two curved double-sided Fresnel lenses
with 2.65 m external diameter, a precision diffractive middle lens and a pupil.
The ultraviolet photons are focused onto the focal surface, which consists of
nearly 5000 multi-anode photomultipliers. It is developed by a large
international collaboration. All three orbital detectors have multi-purpose
character due to continuous monitoring of various atmospheric phenomena. The
present status of development of the TUS and KLYPVE missions is reported, and a
brief comparison of the projects with JEM-EUSO is given.Comment: 18 pages; based on the rapporteur talk given by M.I. Panasyuk at
ECRS-2014; v2: a few minor language issues fixed thanks to the editor; to be
published in the proceeding
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Estimation and Validation of a Multiattribute Model of Alzheimer Disease Progression
OBJECTIVES: To estimate and validate a multiattribute model of the clinical course of Alzheimer disease (AD) from mild AD to death in a high-quality prospective cohort study, and to estimate the impact of hypothetical modifications to AD progression rates on costs associated with Medicare and Medicaid services. DATA AND METHODS: The authors estimated sex-specific longitudinal Grade of Membership (GoM) models for AD patients (103 men, 149 women) in the initial cohort of the Predictors Study (1989-2001) based on 80 individual measures obtained every 6 mo for 10 y. These models were replicated for AD patients (106 men, 148 women) in the 2nd Predictors Study cohort (1997-2007). Model validation required that the disease-specific transition parameters be identical for both Predictors Study cohorts. Medicare costs were estimated from the National Long Term Care Survey. RESULTS: Sex-specific models were validated using the 2nd Predictors Study cohort with the GoM transition parameters constrained to the values estimated for the 1st Predictors Study cohort; 57 to 61 of the 80 individual measures contributed significantly to the GoM models. Simulated, cost-free interventions in the rate of progression of AD indicated that large potential cost offsets could occur for patients at the earliest stages of AD. CONCLUSIONS: AD progression is characterized by a small number of parameters governing changes in large numbers of correlated indicators of AD severity. The analysis confirmed that the progression of AD represents a complex multidimensional physiological process that is similar across different study cohorts. The estimates suggested that there could be large cost offsets to Medicare and Medicaid from the slowing of AD progression among patients with mild AD. The methodology appears generally applicable in AD modeling
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