Development perspectives of new generation medications based on the redox system regulators

This survey paper describes the necessity of the development of new medications influencing the body redox-potential. It supports the most pressing branch of pharmacology, which coincides with logically relevant attempts to shift paradigm of pharmacology from molecular to electronic, quantum-wave. This article covers and logically assorts research results of recent years and opinions of wide range of scientists from various countries. The authors also give their own assessment of the possibility to influence body redox potential. It is reported that some biophysical achievements regarded undoubtedly put a new spin in pharmacology of the biophysical leve

Effects of dimephosphone on skin survival in conditions of reduced blood circulation

The search for and creation of drugs with dermatoprotective and metabotropic activity is one of the priorities of modern diabetology. Synthetic organophosphorus compounds with no anticholinesterase activity, to which dimephosphone belongs to, deserve great attention in this respec

Benzofurocaine: effects on experimental periodontitis, anti-diabetic activity and molecular mechanisms of action

A promising compound for the treatment of inflammatory periodontal diseases is benzofuracaine (BFC). BFC has pronounced anti-inflammatory, analgesic, reparative, hypoglycemic and other effects. Objective: To assess the influence of benzofuracaine on experimental periodontitis and to study its antidiabetic activity and molecular mechanisms of actio

Pharmacokinetic studies derived indole SS-68 with antiarrhythmic and antianginal properties

A method of quantitative determination of SS-68 derivative of indole in rabbit blood plasma by high performance liquid chromatography with tandem mass spectrometric detector (HPLCMS/ MS). Conducted pharmacokinetic studies SS-68 in the body of rabbits. Set the main pharmacokinetic parameters of the substance that allow you to optimize the future use of it’s as a potential drug in cardiology practic

Part I

The problem of heart rhythm disturbances is one of the most urgent topics of modern cardiology. According to the currently available concepts, 1,2- and 1,3-disubstituted aminoindole derivatives, which compound 2-phenyl-1-(3-pyrrolidin-1-il-propyl)-1H-indole hydrochloride (SS-68) belongs to, are a promising chemical group in terms of their cardio-pharmacological activit

Role of indole derivative SS-68 in increasing the frequency range of cardiac rhythm control (reflex stimulation of the sinoatrial node)

The substance SS-68 increases the frequency range of heart rhythm control by activating reflex stimulation of the sinoatrial node. The main point of application of SS-68 is the medulla oblongata. Glow in the high-frequency electromagnetic field reflects the process of neuron excitatio

Pathomorphological analysis of the gum tissues in the application of the combination of Soderm®- Forte gel with Cytoflavin® in experimental periodontitis in rats

The combination of TDT, Soderm®-Forte and Cytoflavin® in EP has a more pronounced therapeutic effect, manifested by early regression of pathological changes and acceleration of tissue regeneration in the gu

The effect of the composition of Soderm-Forte gel and the new injectable form of Rexod on pathology findings in gingival tissue in experimental periodontitis in rats

The combination of TDT, Soderm-Forte gel and the NIF of Rexod shows the most beneficial effect on the pathological processes in the gum. The pharmacotherapeutic effect of the studied combination promotes the earliest regeneration of damaged gum tissues and reduces the risk of persistent pathology changes in the

The influence of the vagus nerve and indole derivative SS-68 on excitation processes in the SA node

The aim of the study was to identify the components of the takeover process of central rhythmogenesis by the SA node in the conditions of atrial fibrillation when stimulating the vagus nerve and using substance SS-6

The role of catecholamines, melatonin and nitric oxide in the mechanisms of stress damage to the body

The mechanisms of response and adaptation of the body’s regulatory systems to stress factors is an urgent fundamental task and the goal of this study. The study used four experimental models of stress: acute stress, chronic stress, and their sequence