1 research outputs found
Fabrication of pH-Responsive Nanoparticles with an AIE Feature for Imaging Intracellular Drug Delivery
Here we have demonstrated a facile
method for construction of self-assembled
nanoparticles with excellent fluorescent properties by the synergetic
combination of unique AIE effects and tadpole-shaped polymers. The
introduction of acid-sensitive Schiff base bonds furnished the polymeric
vesicles and micelles with unique pH responsiveness that can possess
maximal drug-release controllability inside tumor cells upon changes
in physical and chemical environments, but present good stability
under physiological conditions. Having benefited from the efficient
fluorescence resonance energy transfer (FRET), the DOX-loaded fluorescent
aggregates were employed for intracellular imaging and self-localization
in surveillance of systemic DOX delivery. Cytotoxicity assay of the
DOX-loaded aggregates indicated a fast internalization and a high
cellular proliferation inhibition to MCF-7 cells while the PEG-POSS-(TPE)<sub>7</sub> nanoparticles displayed no cytotoxicity, exhibiting excellent
biocompatibility and biological imaging properties. These results
indicated that these biodegradable nanoparticles, as a class of effective
pH-responsive and visible nanocarriers, have the potential to improve
smart drug delivery and enhance the antitumor efficacy for biomedical
applications