Policy actors and policy making for better migrant health in China: From a policy network perspective

Given the phenomenal scale of internal migration in China, migrant health has become a prominent policy issue. Various policy actors are now involved in the development of migrant health policy. However, little is known about who the main policy actors are, what roles they play, how they interact with each other, and how they might improve their collaboration for better migrant health. This paper aims to identify the main policy actors and explore their roles in migrant health policy making. Applying a "policy network" approach, it finds that the marginalization of migrants in terms of health benefits is mainly attributed to a closed policy network resulting from the peculiar political structure and specific institutional arrangements. Based on these findings, the authors argue that an inclusive policy network is needed to overcome the major institutional barriers and better satisfy migrants´ health needs

Complexation of Z-ligustilide with hydroxypropyl-β-cyclodextrin to improve stability and oral bioavailability

To improve the stability and oral bioavailability of Z-ligustilide (LIG), the inclusion complex of LIG with hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared by the kneading method and characterized by UV-Vis spectroscopy, differential thermal analysis (DTA) and Fourier transform infrared (FTIR) spectroscopy. LIG is capable of forming an inclusion complex with HP-β-CD and the stoichiometry of the complex was 1:1. Stability of the inclusion complex against temperature and light was greatly enhanced compared to that of free LIG. Further, oral bioavailability of LIG and the inclusion complex in rats were studied and the plasma drug concentration-time curves fitted well with the non-compartment model to estimate the absolute bioavailability, which was 7.5 and 35.9 %, respectively. In conclusion, these results show that LIG/HP-β-CD complexation can be of great use for increasing the stability and biological efficacy of LIG

Discussion on tunnel bottom excavation method and lining deformation monitoring scheme of operating tunnel

In order to analyze the degree of disturbance to the lining by the full-width excavation and reinforcement of the tunnel bottom, and determine the length of the excavation unit, and the excavation interval and improve the monitoring measurement plan. Through field observation and numerical simulation comparative analysis and verification, it is determined that the deformation of the lining equals mainly the deformation of the side wall, the influence range of the settlement of the side wall is greater than that of the convergence, the maximum value of the maximum principal stress of the lining is mainly distributed from the side wall of the excavation area to the arch line, the side wall of the excavation area produces shear yield when the length of the excavation unit reaches 5m, and the influence area will cross influence when the excavation interval is less than twice the influence area. Based on the distribution law of lining deformation, principal stress and elastoplastic area, it is recommended that the length of the excavation unit should be less than 5m, the excavation interval should be greater than twice the influence range of the side wall settlement; and the monitoring section should be arranged at the central section of the excavation area, the interval of the monitoring section should be determined according to the location of the excavation unit, the monitoring scope may not extend to the unreinforced section, and the settlement of the side walls should be increased

Robust Adaptive Beamforming Based on Worst-Case and Norm Constraint

A novel robust adaptive beamforming based on worst-case and norm constraint (RAB-WC-NC) is presented. The proposed beamforming possesses superior robustness against array steering vector (ASV) error with finite snapshots by using the norm constraint and worst-case performance optimization (WCPO) techniques. Simulation results demonstrate the validity and superiority of the proposed algorithm

Constructing immune and prognostic features associated with ADCP in hepatocellular carcinoma and pan-cancer based on scRNA-seq and bulk RNA-seq

AimDespite the significant therapeutic outcomes achieved in systemic treatments for liver hepatocellular carcinoma (LIHC), it is an objective reality that only a low proportion of patients exhibit an improved objective response rate (ORR) to current immunotherapies. Antibody-dependent cellular phagocytosis (ADCP) immunotherapy is considered the new engine for precision immunotherapy. Based on this, we aim to develop an ADCP-based LIHC risk stratification system and screen for relevant targets.MethodUtilizing a combination of single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data, we screened for ADCP modulating factors in LIHC and identified differentially expressed genes along with their involved functional pathways. A risk scoring model was established by identifying ADCP-related genes with prognostic value through LASSO Cox regression analysis. The risk scoring model was then subjected to evaluations of immune infiltration and immunotherapy relevance, with pan-cancer analysis and in vitro experimental studies conducted on key targets.ResultsBuilding on the research by Kamber RA et al., we identified GYPA, CLDN18, and IRX5 as potential key target genes regulating ADCP in LIHC. These genes demonstrated significant correlations with immune infiltration cells, such as M1-type macrophages, and the effectiveness of immunotherapy in LIHC, as well as a close association with clinical pathological staging and patient prognosis. Pan-cancer analysis revealed that CLDN18 was prognostically and immunologically relevant across multiple types of cancer. Validation through tissue and cell samples confirmed that GYPA and CLDN18 were upregulated in liver cancer tissues and cells. Furthermore, in vitro knockdown of CLDN18 inhibited the malignancy capabilities of liver cancer cells.ConclusionWe have identified an ADCP signature in LIHC comprising three genes. Analysis based on a risk scoring model derived from these three genes, coupled with subsequent experimental validation, confirmed the pivotal role of M1-type macrophages in ADCP within LIHC, establishing CLDN18 as a critical ADCP regulatory target in LIHC

Approach to Higher Wheat Yield in the Huang-Huai Plain: Improving Post-anthesis Productivity to Increase Harvest Index

Both increased harvest index (HI) and increased dry matter (DM) are beneficial to yield; however, little is known about the priority of each under different yield levels. This paper aims to determine whether HI or DM is more important and identify the physiological attributes that act as indicators of increased yield. Two field experiments involving different cultivation patterns and water-nitrogen modes, respectively, were carried out from 2013 to 2016 in Huang-Huai Plain, China. Plant DM, leaf area index (LAI), and radiation interception (RI) were measured. Increased yield under low yield levels <7500 kg ha-1 was attributed to an increase in both total DM and HI, while increases under higher yield levels >7500 kg ha-1 were largely dependent on an increase in HI. Under high yield levels, HI showed a significant negative correlation with total DM and a parabolic relationship with net accumulation of DM during filling. Higher net accumulation of DM during filling helped slow down the decrease in HI, thereby maintaining a high value. Moreover, net DM accumulation during filling was positively correlated with yield, while post-anthesis accumulation showed a significant linear relationship with leaf area potential (LAP, R2 = 0.404–0.526) and radiation interception potential (RIP, R2 = 0.452–0.576) during grain filling. These findings suggest that the increase in LAP and RIP caused an increase in net DM accumulation after anthesis. Under DM levels >13,000 kg ha-1 at anthesis, maintaining higher LAI and RI in lower layers during grain formation contributed to higher yield. Furthermore, the ratio of upper- to lower-layer RI showed a second-order curve with yield during filling, with an increase in the optimal range with grain development. Pre-anthesis translocation amount, translocation ratios and contribution ratios also showed second-order curves under high yield levels, with optimal values of 3000–4500 kg ha-1, 25–35, and 30–50%, respectively. These results confirm the importance of HI in improving the yield, thereby providing a theoretical basis for wheat production in the Huang-Huai Plain

Formation, influencing factors, and applications of internal channels in starch: A review

Starch, a natural polymer, has a complex internal structure. Some starches, such as corn and wheat starches, have well-developed surface pores and internal channels. These channel structures are considered crucial in connecting surface stomata and internal cavities and have adequate space for loading guest molecules. After processing or modification, the starch-containing channel structures can be used for food and drug encapsulation and delivery. This article reviews the formation and determination of starch internal channels, and the influence of different factors (such as starch species and processing conditions) on the channel structure. It also discusses relevant starch preparation methods (physical, chemical, enzymatic, and synergistic), and the encapsulation effect of starch containing internal channels on different substances. In addition, the role of internal channels in regulating the starch digestion rate and other aspects is also discussed here. This review highlights the significant multifunctional applications of starch with a channel structure

Fifty-year climate change and its effect on annual runoff in the Tarim River Basin, China

Based on the hydrologic and meteorological data in the Tarim River basin from 1958 to 2004, the trend, characteristics and spatial variation of climate change in the upper reaches of the Tarim River were examined in the study. The long-term trend of climate change and hydrological variations were determined by using both Mann-Kendall and Mann-Whitney nonparametric tests. The results showed that the temperature and precipitation had significantly increased in the drainage basin in the mid-1980s. The climate was the warmest in 1990s among the recent 50 years. The increase of temperature in the tributaries of the Aksu River and Kaidu-Kongque River is higher than that in the tributaries of the Yarkand River and Hotan River. The streamflow at Aksu River showed a significant increasing monotonic trend. The annual runoff in the Aksu River had increased by 10.9% since 1990. The independence test of temperature and precipitation with chi(2) of the El Nino event reveals that there is no significant effect of the El Nino and La Nina events on the annual temperature and annual precipitation in the drainage basin. (C) 2008 Elsevier Ltd and INQUA. All rights reserved

Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line

The determination of individual cell trajectories through a high-dimensional cell-state space is an outstanding challenge for understanding biological changes ranging from cellular differentiation to epigenetic responses of diseased cells upon drugging. We integrate experiments and theory to determine the trajectories that single BRAF^(V600E) mutant melanoma cancer cells take between drug-naive and drug-tolerant states. Although single-cell omics tools can yield snapshots of the cell-state landscape, the determination of individual cell trajectories through that space can be confounded by stochastic cell-state switching. We assayed for a panel of signaling, phenotypic, and metabolic regulators at points across 5 days of drug treatment to uncover a cell-state landscape with two paths connecting drug-naive and drug-tolerant states. The trajectory a given cell takes depends upon the drug-naive level of a lineage-restricted transcription factor. Each trajectory exhibits unique druggable susceptibilities, thus updating the paradigm of adaptive resistance development in an isogenic cell population