Management buyouts and board transformation in China’s transition economy

Management buyouts (MBOs) involving the acquisition of firms by incumbent managers by who take on financial leverage, often with the involvement of private equity firms (Gilligan and Wright 2010), have become an international phenomenon. Over three decades they have diffused from the US, to Europe and to Asia (Wright et al. 2007). From OECD countries they have also played an important role in the transformation of Central and Eastern Europe (Wright et al. 1994) and more recently have emerged in China (Sun et al. 2010)

This is the selection diagram.

The impact of critical illness on patients is profound, resulting in physical, mental, and social consequences and poor health-related quality of life (HRQOL). Several studies investigated HRQOL among patients discharged from the intensive care unit (ICU). However, few systematic reviews cover studies conducted in the last decade or using valid instruments for measuring HRQOL in general ICU survivor populations. Herein, we conduct a systematic review of these studies that followed PRISMA guidelines. We will search PubMed, Web of Science, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane Library, and Open Grey for papers. We will search for articles reporting the HRQOL of ICU survivors that were written in English and published from 01 January 2012 onward from the date of this protocol’s publication. We will also extract HRQOL data and analyze associate factors. The risk of bias will be measured with a standard quality assessment tool. The strength of the results will depend on the number of studies and the consistency of their results.Trial registration number: PROSPERO CRD 42022304279.</div

This is the PRISMA-P 2015 checklist.

The impact of critical illness on patients is profound, resulting in physical, mental, and social consequences and poor health-related quality of life (HRQOL). Several studies investigated HRQOL among patients discharged from the intensive care unit (ICU). However, few systematic reviews cover studies conducted in the last decade or using valid instruments for measuring HRQOL in general ICU survivor populations. Herein, we conduct a systematic review of these studies that followed PRISMA guidelines. We will search PubMed, Web of Science, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane Library, and Open Grey for papers. We will search for articles reporting the HRQOL of ICU survivors that were written in English and published from 01 January 2012 onward from the date of this protocol’s publication. We will also extract HRQOL data and analyze associate factors. The risk of bias will be measured with a standard quality assessment tool. The strength of the results will depend on the number of studies and the consistency of their results.Trial registration number: PROSPERO CRD 42022304279.</div

Chinese management buyouts and board transformation

We assess the extent to which Chinese MBOs of listed corporations enable a balance to be achieved between facilitating growth and supporting the interests of minority shareholders other than the buyout organization. Using novel, hand-collected data from 19 MBOs of listed corporations in China, a matched sample of 19 non-MBOs and the population of listed corporations, we examine the extent to which boards of directors are changed to bring in executive and outside directors with the skills to grow as well as restructure a business. We also examine the extent to which outside directors become involved in actions to develop the business rather than actions related to fostering the interests of all shareholders. We find in fact little evidence that outside board members have the skills to add value to the MBO firms. Boards appear to focus mainly on related-party transactions with some more limited attention to growth strategies. Outside directors do not seem to openly disagree with incumbent managers on the disclosure of their actions but may express their views and exert pressure behind the scenes

Electrostatic Interfacial Cross-Linking and Structurally Oriented Fiber Constructed by Surface-Modified 2D MXene for High-Performance Flexible Pseudocapacitive Storage

Fiber supercapacitors are promising power supplies suitable for wearable electronics, but the internally insufficient cross-linking and random structure of fiber electrodes restrict their performance. This study describes how interfacial cross-linking and oriented structure can fabricate an MXene fiber with high flexibility and electrochemical performance. The continuous and highly oriented macroscopic fibers were constructed by 2D MXene sheets via a liquid-crystalline wet-spinning assembly. The oxyanion-enriched terminations of surface-modified MXene in situ could reinforce the interfacial cross-linking by electrostatic interactions while mediating the sheet-to-sheet lamellar structure within the fiber. The resultant MXene fiber exhibits high electrical conductivity (3545 S cm–1) and mechanical strength (205.5 MPa) and high pseudocapacitance charge storage capability up to 1570.5 F cm–3. Notably, the assembled fiber supercapacitor delivers an energy density of 77.6 mWh cm–3 at 401.9 mW cm–3, exceptional flexibility and stability exhibiting ∼99.5% capacitance retention under mechanical deformation, and can be integrated into commercial textiles to power microelectronic devices. This work provides insight into the fabrication of an advanced MXene fiber and the development of high-performance flexible fiber supercapacitors

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3D photoacoustic image of mouse le

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Table1_Identification and verification of IGFBP3 and YTHDC1 as biomarkers associated with immune infiltration and mitophagy in hypertrophic cardiomyopathy.DOCX

Background: Hypertrophic cardiomyopathy (HCM) is the main cause of sudden cardiac death among young adults, yet its pathogenesis remains vague. N6-methyladenosine (m6A) methylation modification was involved in various cardiovascular diseases such as coronary heart disease and heart failure, although its influence on HCM remains unclear. This study aimed to explore the potential role of m6A in the diagnosis and pathogenesis of HCM.Methods: GSE36961 including 106 HCM and 39 controls was used in the study. The HCM-related m6A regulators were selected using support vector machine recursive feature elimination and random forest algorithm. A significant gene signature was then established using least absolute shrinkage and selection operator and then verified by GSE130036. Subgroup classification of HCM was performed based on the expression of m6A biomarkers. Gene set variation analysis was employed to explore the functional difference between distinct subgroups. Weighted gene co-expression network analysis was used to determine the m6A-related hub module. Single-sample gene set enrichment analysis was conducted to assess the immune and mitophagy features between subgroups. Besides, transfection of recombinant plasmids with targeted genes into H9c2 cells was performed to further verify the function of the significant biomarkers.Results: Significant difference existed in m6A landscape between HCM and control patients, among which IGFBP3 and YTHDC1 were identified as the independent biomarkers of HCM. Highly infiltrated immune cells (MDSC, macrophages, etc.), more enriched immune-related pathways (TNFα signaling via NFκB and IL6-JAK-STAT3 signaling) and cardiac remodeling-associated pathways (epithelial mesenchymal transition, angiogenesis, etc.) were identified in the subgroup with higher IGFBP3. Consistently, overexpression of IGFBP3 in H9c2 cells led to upregulation of extracellular-matrix-related genes (COL1A2, COL3A1 and MMP9) and inflammation-related genes (TNFα and IL6). Besides, higher YTHDC1 expression seemed to be consistent with less-activated mitophagy (PINK1-PRKN mediated mitophagy) and energy metabolism. Further experiments demonstrated that overexpression of YTHDC1 resulted in up-regulation of PINK and PRKN in cardiomyocytes, which are essential genes mediating mitophagy.Conclusion: Two m6A readers (IGFBP3 and YTHDC1) well distinguished HCM and may facilitate clinical diagnosis. IGFBP3 may play a role in the immune-microenvironments and remodeling of cardiac tissues, while YTHDC1 may influence mitophagy and energy metabolism in HCM.</p

Comparison of the predicted values and experimental values.

<p>Comparison of the predicted values and experimental values.</p

Design space and the verification experiment.

<p>(Color bar refers to the probability to attain CQA criteria; △, verification experiment; the region within the white line is the design space).</p