7,468 research outputs found
Anti-obesity effect of an isoflavone fatty acid ester on obese mice induced by high fat diet and its potential mechanism
<p>Abstract</p> <p>Background</p> <p>The novel compound <b>1a </b>is one of the isoflavone fatty acid esters. In order to investigate the anti-obesity effect of compound <b>1a </b>and its potential mechanism of influence in adipocyte differentiation, Obese male C57BL/6J mice induced by high-fat diet (HFD) and rat preadipocytes (3T3-L1 cell) were used.</p> <p>Methods</p> <p>After 4-week HFD induction, the obese model was made successfully. After treatment with compound <b>1a</b>, mice plasma biochemistry parameters were analyzed. In addition, mice hepatic tissue slice was observed. In <it>in vitro </it>research, 3T3-L1 cell differentiation by Oil-Red-O staining and adipocyte apoptosis was detected by flow cytometry.</p> <p>Results</p> <p>The <it>in vivo </it>results implied that compound <b>1a </b>significantly decreased the body weight, white adipose tissue weight of obesity mice(p < 0.05), reduced leptin and TG in plasma(p < 0.05), elevated HDL-C in serum(p < 0.05). The <it>in vitro </it>results suggested that compound <b>1a </b>could significantly suppress the adipocyte viability and lipid accumulation in the differentiation of preadipocyte, and induce apoptosis in both preadipocytes and mature adipocytes(p < 0.05).</p> <p>Conclusion</p> <p>Compound <b>1a </b>regulates serum lipid profiles, decreases adipose tissue mass and body weight gain by inducing adipocyte apoptosis in high fat diet induced mice. Thus, it may be used to treat obese patients with hypercholesterolemia and hypertriglyceridemia.</p
On the spectral radius of weighted trees with fixed diameter and weight set
AbstractThe spectrum of weighted graphs are often used to solve the problems in the design of networks and electronic circuits. We first give some perturbational results on the spectral radius of weighted graphs when some weights of edges are modified, then we derive the weighted tree with the largest spectral radius in the set of all weighted trees with fixed diameter and weight set. Furthermore, an open problem of spectral radius on weighted paths is solved [H.Z. Yang, G.Z. Hu, Y. Hong, Bounds of spectral radii of weighted tree, Tsinghua Science and Technology 8 (2003) 517–520]
Can interacting dark energy with dynamical coupling resolve the Hubble tension
The tension between low- and high- redshift measurements is definitely
a serious issue faced by current cosmologists since it ranges from 4 to
6. To relieve this tension, in this paper we propose a new interacting
dark energy model with time varying coupling parameter by parameterizing the
densities of dark matter and dark energy, this parametric approach for
interacting dark sectors are inspired by our previous work concerning the
coupled generalized three-form dark energy model in which dark matter and dark
energy behave like two uncoupled dark sectors with effective equation of state
when the three-form , for this reason, we reconstruct coupled
generalized three-form dark energy from such parametric model under the
condition . In the end, we place constraints on the
parametric model with the coupled generalized three-form dark energy model
proposed in our previous work in light of the Planck 2018 cosmic microwave
background (CMB) distance priors, baryon acoustic oscillations (BAO) data from
the BOSS Data Release (DR) 12, Pantheon compilation of Type Ia supernovae (SN
Ia) data and the latest local determinations of the Hubble constant from Riess
et al., i.e. the so called R20. The fitting results show that, comparing to
R20, the parametric model relieves the Hubble tension to 0.05 with
and the coupled generalized three-form dark energy
model relieves the Hubble tension to 0.70 with .
However, it is worth noting that the tiny Hubble tension between R20 and the
parametric model is mostly due to the fact that the introduction of the
parameter greatly increase the uncertainty of the Hubble constant obtained
without using a prior.Comment: 11 pages, 4 figures, has been submitted to PR
The Oblique Corrections from Heavy Scalars in Irreducible Representations
The contributions to , , and from heavy scalars in any irreducible
representation of the electroweak gauge group are
obtained. We find that in the case of a heavy scalar doublet there is a slight
difference between the parameter we have obtained and that in previous
works.Comment: 6 pages, 2 axodraw figures; minor changes, references update
5,5′,5′′-Triphenyl-2,2′,2′′-[2,4,6-trimethylbenzene-1,3,5-triyltris(methylidenesulfanediyl)]tris(1,3,4-oxadiazole)
In the title compound, C36H30N6O3S3, the phenyl rings are twisted from the attached oxadiazole rings in the three arms by 1.5(2), 2.4 (2) and 25.7 (2)°. The crystal packing exhibits weak intermolecular C—H⋯N interactions
5,5′-Diphenyl-2,2′-[butane-1,4-diylbis(sulfanediyl)]bis(1,3,4-oxadiazole)
The complete molecule of the title compound, C20H18N4O2S2, is generated by crystallographic inversion symmetry. The benzene ring is almost coplanar with the oxadiazole ring [dihedral angle = 7.2 (2)°]
Massive Color-Kinematics Duality and Double-Copy for Kaluza-Klein Scattering Amplitudes
We study the scattering amplitudes of massive Kaluza-Klein (KK) states under
toroidal compactification. We present a shifting method to quantitatively
derive the scattering amplitudes of massive KK gauge bosons and KK gravitons
from the corresponding massless amplitudes in the noncompactified higher
dimensional theories. With these we construct the massive KK scattering
amplitudes by extending the double-copy relations of massless scattering
amplitudes within the field theory framework, including both the BCJ and CHY
methods, and build up their connections to the massive KK KLT relations. We
present the massive BCJ-type double-copy construction of the -point KK gauge
boson/graviton scattering amplitudes, and as the applications we derive
explicitly the four-point KK scattering amplitudes as well as the five-point KK
scattering amplitudes. We further study the nonrelativistic limit of these
massive scattering amplitudes with the heavy external KK states and discuss the
impact of the compactified extra dimensions on the low energy gravitational
potential. Finally, we analyze the four-point and -point mass spectral
conditions and newly propose a novel group theory approach to prove that only
the KK theories under toroidal compactification can satisfy these conditions
for directly realizing massive double-copy in the field theory framework.Comment: 73 pages, JHEP final version. Only minor refinements, references
adde
Efficient -separability criteria for mixed multipartite quantum states
We investigate classification and detection of entanglement of multipartite
quantum states in a very general setting, and obtain efficient -separability
criteria for mixed multipartite states in arbitrary dimensional quantum
systems. These criteria can be used to distinguish different classes of
multipartite inseparable states and can detect many important multipartite
entangled states such as GHZ states, W states, anti W states, and mixtures
thereof. They detect -nonseparable -partite quantum states which have
previously not been identified. Here . No optimization or
eigenvalue evaluation is needed, and our criteria can be evaluated by simple
computations involving components of the density matrix. Most importantly, they
can be implemented in today's experiments by using at most
local measurements.Comment: 6 pages, 4 figure
- …