4,151 research outputs found
AdLER: Adversarial Training with Label Error Rectification for One-Shot Medical Image Segmentation
Accurate automatic segmentation of medical images typically requires large
datasets with high-quality annotations, making it less applicable in clinical
settings due to limited training data. One-shot segmentation based on learned
transformations (OSSLT) has shown promise when labeled data is extremely
limited, typically including unsupervised deformable registration, data
augmentation with learned registration, and segmentation learned from augmented
data. However, current one-shot segmentation methods are challenged by limited
data diversity during augmentation, and potential label errors caused by
imperfect registration. To address these issues, we propose a novel one-shot
medical image segmentation method with adversarial training and label error
rectification (AdLER), with the aim of improving the diversity of generated
data and correcting label errors to enhance segmentation performance.
Specifically, we implement a novel dual consistency constraint to ensure
anatomy-aligned registration that lessens registration errors. Furthermore, we
develop an adversarial training strategy to augment the atlas image, which
ensures both generation diversity and segmentation robustness. We also propose
to rectify potential label errors in the augmented atlas images by estimating
segmentation uncertainty, which can compensate for the imperfect nature of
deformable registration and improve segmentation authenticity. Experiments on
the CANDI and ABIDE datasets demonstrate that the proposed AdLER outperforms
previous state-of-the-art methods by 0.7% (CANDI), 3.6% (ABIDE "seen"), and
4.9% (ABIDE "unseen") in segmentation based on Dice scores, respectively. The
source code will be available at https://github.com/hsiangyuzhao/AdLER
Monoclinic form of (Z)-1-ferrocenyl-3-(3-hydroxyanilino)but-2-en-1-one
The title compound, [Fe(C5H5)(C15H14NO2)], is a monoclinic polymorph of the previously reported triclinic form [Shi et al. (2006 ▶). Acta Cryst. C62, m407–m410]. The polymorphs feature the same strong intramolecular N—H⋯O=C hydrogen bonds, but show different packing modes. The molecules in the monoclinic form associate into double chains via O—H⋯O=C and (Cp)C—H⋯O—H interactions
Direct phasing of one-wavelength anomalous-scattering data of the protein core streptavidin
The direct method [Fan, Hao, Gu, Qian, Zheng & Ke (1990). Acta Cryst. A46, 935-939] was used to break the phase ambiguity intrinsic to one-wavelength anomalous scattering data from a known protein of moderate size, core streptavidin, which was solved originally with three-wavelength anomalous diffraction data [Hendrickson, Pähler, Smith, Satow, Merritt & Phizackerley (1989). Proc. Natl Acad. Sci. USA, 86, 2190-2194]. Unlike that in the previous test with a small protein, the Fourier map calculated with the direct-method phases could not clearly reveal the moderate-sized protein structure. However, the phases can be improved step by step using Wang's solvent-flattening method, non-crystallographic symmetry averaging and the skeletonization method. The final electron-density map clearly shows most Calpha positions and some side chains and it is traceable without prior knowledge of the structure. It is concluded that the direct method is capable of breaking the OAS phase ambiguity of a moderate-sized protein at moderate resolution such as 3 A, while the combination of direct methods with macromolecular techniques may produce phases good enough for unknown protein structure to be traced
Surgical treatment strategy for multiple injury patients in ICU
AbstractObjectiveTo investigate the surgical treatment for patients with multiple injuries in ICU.MethodsClinical data of 163 multiple injury patients admitted to ICU of our hospital from January 2006 to January 2009 were retrospectively studied, including 118 males and 45 females, with the mean age of 36.2 years (range, 5-67 years). The injury regions included head and neck (29 cases), face (32 cases), chest (89 cases), abdomen (77 cases), pelvis and limbs (91 cases) and body surface (83 cases). There were 57 cases combined with shock. ISS values varied from 10 to 54, 18.42 on average. Patients received surgical treatments in ICU within respectively 24 hours (10 cases), 24-48 hours (8 cases), 3-7 days (7 cases) and 8-14 days (23 cases).ResultsFor the 163 patients, the duration of ICU stay ranged from 2 to 29 days, with the average value of 7.56 days. Among them, 143 were cured (87.73%), 11 died in the hospital (6.75%) due to severe hemorrhagic shock (6 cases), craniocerebral injury (3 cases) and multiple organ failure (2 cases), and 9 died after voluntarily discharging from hospital (5.52%). The total mortality rate was 12.27%.ConclusionsThe damage control principle should be followed when multiple injury patients are resuscitated in ICU. Surgical treatment strategies include actively controlling hemorrhage, treating the previously missed injuries and related wounds or surgical complications and performing planned staging operations
Scaling of Berry-curvature monopole dominated large linear positive magnetoresistance
The linear positive magnetoresistance (LPMR) is a widely observed phenomenon
in topological materials, which is promising for potential applications on
topological spintronics. However, its mechanism remains ambiguous yet and the
effect is thus uncontrollable. Here, we report a quantitative scaling model
that correlates the LPMR with the Berry curvature, based on a ferromagnetic
Weyl semimetal CoS2 that bears the largest LPMR of over 500% at 2 Kelvin and 9
Tesla, among known magnetic topological semimetals. In this system, masses of
Weyl nodes existing near the Fermi level, revealed by theoretical calculations,
serve as Berry-curvature monopoles and low-effective-mass carriers. Based on
the Weyl picture, we propose a relation , with B being the applied magnetic field and the average Berry curvature near the Fermi surface, and further
introduce temperature factor to both MR/B slope (MR per unit field) and
anomalous Hall conductivity, which establishes the connection between the model
and experimental measurements. A clear picture of the linearly slowing down of
carriers, i.e., the LPMR effect, is demonstrated under the cooperation of the
k-space Berry curvature and real-space magnetic field. Our study not only
provides an experimental evidence of Berry curvature induced LPMR for the first
time, but also promotes the common understanding and functional designing of
the large Berry-curvature MR in topological Dirac/Weyl systems for magnetic
sensing or information storage
Undecacarbonyl-μ2-methanethiolato-μ2-[(pyridin-2-yl)methanethiolato]-μ4-sulfido-tetrairon(II)(2 Fe—Fe)
The title compound, [Fe4(C6H6NS)(CH3S)S(CO)11], comprises two butterfly-shaped sub-cluster cores, Fe2S2N and Fe2S2, joined together by a spiro-type μ4-S atom. The (pyridin-2-yl)methanethiolate ligand is attached to the Fe2(CO)5 unit in a μ-κN:κ2
S mode, and the methanethiolate ligand is coordinated to the Fe2(CO)6 unit in a μ-κ2
S fashion
The impact of cognitive training on cerebral white matter in community-dwelling elderly : one-year prospective longitudinal diffusion tensor imaging study
It has been shown that cognitive training (CogTr) is effective and recuperative for older adults, and can be used to fight against cognitive decline. In this study, we investigated whether behavioural gains from CogTr would extend to white matter (WM) microstructure, and whether training-induced changes in WM integrity would be associated with improvements in cognitive function, using diffusion tensor imaging (DTI). 48 healthy community elderly were either assigned to multi-domain or single-domain CogTr groups to receive 24 sessions over 12 weeks, or to a control group. DTI was performed at both baseline and 12-month follow-up. Positive effects of multi-domain CogTr on long-term changes in DTI indices were found in posterior parietal WM. Participants in the multi-domain group showed a trend of long-term decrease in axial diffusivity (AD) without significant change in fractional anisotropy (FA), mean diffusivity (MD) or radial diffusivity (RD), while those in the control group displayed a significant FA decrease, and an increase in MD and RD. In addition, significant relationships between an improvement in processing speed and changes in RD, MD and AD were found in the multi-domain group. These findings support the hypothesis that plasticity of WM can be modified by CogTr, even in late adulthood
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