Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients

<div><p>Background</p><p>Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dialysis adequacy, insulin resistance, and bone metabolism status in patients on peritoneal dialysis.</p><p>Methods</p><p>A total of 59 nondiabetic prevalent peritoneal dialysis patients and 52 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Serum irisin concentration was assessed by enzyme-linked immunosorbent assay. The correlations between serum irisin and dialysis adequacy, clinical, and metabolic variables were investigated.</p><p>Results</p><p>Serum irisin levels were lower in nondiabetic peritoneal dialysis patients (17.02ng/ml) compared with healthy controls (22.17ng/ml, P<0.001). Multivariate regression analysis revealed that fasting glucose levels were correlated inversely with serum irisin levels in peritoneal dialysis patients. Serum irisin levels were associated with neither insulin resistance nor bone metabolism in our patients. Serum irisin levels were positively associated with peritoneal Kt/V_urea (β = 4.933, 95% confidence interval [CI] = 0.536–9.331, P = 0.029) and peritoneal C_Cr (β = 0.259, 95% CI = 0.053–0.465, P = 0.015) among peritoneal dialysis patients.</p><p>Conclusions</p><p>The study demonstrated that non-diabetic peritoneal dialysis patients have lower serum irisin levels, and the levels were correlated with peritoneal dialysis adequacy, indicating adequate dialysis may improve irisin secretion. Additional studies are needed to provide a confirmation.</p></div

Associations of serum irisin levels and bone turnover markers.

<p>Associations of serum irisin levels and bone turnover markers.</p

Irisin levels in PD patients and healthy controls.

<p>The box represents median and interquartile ranges, and error bars show the minimum and the maximum.***<i>P</i><0.001.</p

Univariate correlations with circulation irisin levels.

<p>Univariate correlations with circulation irisin levels.</p

Baseline demographic and clinical parameters of subjects.

<p>Baseline demographic and clinical parameters of subjects.</p