Just ClozE! A Novel Framework for Evaluating the Factual Consistency Faster in Abstractive Summarization

The issue of factual consistency in abstractive summarization has received extensive attention in recent years, and the evaluation of factual consistency between summary and document has become an important and urgent task. Most of the current evaluation metrics are adopted from the question answering (QA) or natural language inference (NLI) task. However, the application of QA-based metrics is extremely time-consuming in practice while NLI-based metrics are lack of interpretability. In this paper, we propose a cloze-based evaluation framework called ClozE and show the great potential of the cloze-based metric. It inherits strong interpretability from QA, while maintaining the speed of NLI- level reasoning. We demonstrate that ClozE can reduce the evaluation time by nearly 96% relative to QA-based metrics while retaining their interpretability and performance through experiments on six human-annotated datasets and a meta-evaluation benchmark GO FIGURE (Gabriel et al., 2021). Finally, we discuss three important facets of ClozE in practice, which further shows better overall performance of ClozE compared to other metrics.Comment: The manuscript for JAI

Research progress on the role and mechanism of ADAMTS9 in atherosclerosis

Atherosclerosis is an inflammatory disease of arterial stenosis caused by the imbalance of lipid metabolism and atherosclerotic plaques clustered on the arterial wall. It is the main pathological process of vascular diseases， such as stroke and coronary heart disease， etc. Atherosclerotic diseases yield high disability and death rates. Recent relevant studies have reported that ADAMTS9 is closely correlated with vascular pathophysiological processes. ADAMTS9 can degrade and assemble extracellular matrix， enhance vascular smooth muscle cell proliferation and migration， provoke pro-inflammatory response， promote intimal thickening， accelerate plaque rupture， and exert anti-angiogenesis effect. In this article， the role and mechanism of ADAMTS9 in the incidence and development of atherosclerosis were mainly summarized

Trends in sperm quality by computer-assisted sperm analysis of 49,189 men during 2015–2021 in a fertility center from China

BackgroundSperm quality, including semen volume, sperm count, concentration, and total and progressive motility (collectively, “semen parameters”), has declined in the recent decades. Computer-assisted sperm analysis (CASA) provides sperm kinematic parameters, and the temporal trends of which remain unclear. Our objective is to examine the temporal trend of both semen parameters and kinematic parameters in Shanghai, China, in the recent years.MethodsThis retrospective study analyzed semen parameters and kinematic parameters of 49,819 men attending our reproductive center by using CASA during 2015–2021. The total sample was divided into two groups: samples that surpassed the WHO guideline (2010) low reference limits (“above reference limit” group, ARL; n = 24,575) and samples that did not (“below reference limit” group, BRL; n = 24,614). One-way analysis of variance, Kruskal–Wallis test, independent samples t-test, and covariance analysis were used to assess the differences among groups. Year, age, and abstinence time were included in the multiple linear regression model of the ARL group to adjust the confounders and depict the trends in sperm quality.ResultsAmong all the total sample and the ARL and BRL groups, the age of subjects increased in recent years. Semen volume and sperm count showed declined tendency with years in the total sample, the ARL and BRL groups, and the subgroup of age or abstinence time, whereas sperm velocities showed increased tendency with years on the contrary. The multiple linear regression model of the ARL group, adjusting for age and abstinence time, confirmed these trends. Semen volume (β1= −0.162; CI: −0.172, −0.152), sperm count (β1= −9.97; CI: −10.813, −9.128), sperm concentration (β1 = −0.535; CI: −0.772, −0.299), motility (β1 = −1.751; CI: −1.830, −1.672), and progressive motility (β1 = −1.12; CI: −0.201, −0.145) decreased with year, whereas curvilinear line velocity (VCL) (β1 = 3.058; CI: 2.912, 3.203), straight line velocity (VSL) (β1 = 2.075; CI: 1.990, 2.161), and average path velocity (VAP) (β1 = 2.305; CI: 2.224, 2.386) increased over time (all p < 0.001). In addition, VCL, VSL, and VAP significantly declined with age and abstinence time.ConclusionThe semen parameters declined, whereas the kinematic parameters increased over the recent years. We propose that, although sperm count and motility declined over time, sperm motion velocity increased, suggesting a possible compensatory mechanism of male fertility

Nanoindentation induced anisotropy of deformation and damage behaviors of MgF2 crystals

The competition mechanism between the slip motions and cleavage fractures is related to the anisotropy of deformation behaviors, which is essential to manufacture complex optical components. To identify competition mechanism between the slip motions and cleavage fractures and reveal the anisotropy of deformation and damage behaviors of MgF2 crystals, the nanoindentation tests were systematically conducted on different crystal planes. In addition, the stress induced by the nanoindentation was developed and decomposed along the slip systems and cleavage planes, and cleavage factors and Schmid factors were calculated. The stress, cleavage factors and Schmid factors indicated that the activation degree of the slip motions and cleavage fractures determined the indentation morphologies. Under the same indentation conditions, the nanoindentation of the (001) crystal plane activated most slip motions, so the plastic deformation is most prone to occur on this crystal plane. The nanoindentation of the (010) crystal plane activated less slip motions and most cleavage fractures, resulting in the severest brittle fractures on the (010) crystal plane. The theoretical results consisted well with the experimental results, which provides the theoretical guidance to the low-damage manufacturing of MgF2 components

Probing the wear characteristics of graphene on flexible polymer substrates using a heated atomic force microscopy tip

Graphene is a useful solid lubricant for flexible micro/nanoelectromechanical systems (MEMS/NEMS) because of its beneficial mechanical properties. However, understanding the tribological and wear characteristics of graphene on polymer substrates under high-temperature conditions is essential for predicting whether graphene will fail as a solid lubricant for flexible substrates in high-temperature environments. Herein, the friction and wear characteristics of monolayer graphene on flexible polydimethylsiloxane (PDMS) substrates are studied by atomic force microscopy using a heated tip. The friction of graphene before wear is more stable than that of PDMS, demonstrating that graphene can be used as a solid lubricant to stabilize the stick-slip motion of the tip on the flexible substrate at elevated temperatures. The friction of graphene shows an increasing trend with the heating temperature increasing due to an enlarged tip-graphene contact area. However, the friction of graphene considerably decreases with the tip sliding velocity increasing at a speed of less than 0.5 µm/s, resulting from a reduced tip-graphene contact area. The thermally-induced wear of graphene is caused by the coupling effect of the temperature and the sliding velocity. These results can provide an in-depth understanding of graphene as a solid lubricant for flexible polymer-based MEMS/NEMS devices in high-temperature environments

Gandouling alleviates nerve injury through PI3K/Akt/FoxO1 and Sirt1/FoxO1 signaling pathway to inhibit autophagy in the rats model of Wilson's disease

Abstract Introduction Previous studies have shown that Gandouling (GDL) may alleviate the nerve damage caused by Wilson's disease (WD) by inhibiting the autophagy of nerve cell mitochondria. However, its mechanisms are still unclear. Revealing the therapeutic mechanism of GDL is beneficial for its clinical application and provides theoretical support for the development of new formulations for treating WD. Method This time we found that the oxidative stress level in the body of the copper‐overloaded WD rates increased, neurons in the hippocampus were damaged, and autophagy occurred. GDL reversed these situations and significantly improved the learning, memory, and spatial cognitive abilities of the high‐copper‐loaded WD rates. After GDL intervention, the expression of phosphatidylinositol‐3 kinase (PI3K), phosphorylated serine–threonine protein kinase (AKT), and phosphorylated forkhead box protein O1 (FoxO1) significantly increased, whereas FoxO1 in the nucleus decreased and phosphorylated FoxO1 in the cytoplasm also significantly raised. In addition, the expression of Sirt1 significantly declined, and Ac‐FoxO1 in the nucleus also significantly increased. Results These data indicated that GDL may promote the phosphorylation of FoxO1 and promote its nucleation by activating the PI3K/AKT/FoxO1 signaling pathway and inhibit Ac‐FoxO1 hydrolysis in the nucleus through the Sirt1/FoxO1 signaling pathway to suppress the transcriptional activity of FoxO1. Conclusion Furthermore, it inhibited the expression of autophagy genes Atg12 and Gabarapl1. In summary, our work provides new insights into the potential mechanisms of GDL repairing WD neuronal damage through autophagy pathways

Molecular dynamics simulation of the tool geometry effect on nanowire formation behavior during nanoskiving

Au nanowires have been promoted in flexible electronics, micro-nano bioelectrodes, and micro-electrochemical detection benefit from their inherent size effect, unique chemical stability, and biocompatibility. Nanoskiving methodology has been confirmed as a feasible approach to preparing multidimensional nanostructures simply and efficiently utilizing ultramicrotome. However, the morphology, dimension, and microstructure of the nanowires will be altered by the tool geometry under extrusion and shearing during the nanoskiving process. Herein, a molecular dynamics simulation and experiments of cutting polycrystalline Au utilizing nanoskiving were performed, and the nanowire formation behavior caused by the variation of the tool geometry was analyzed. Smaller rake angle and larger tool cutting edge radius favor thicker chip thickness, larger high-stress areas, increased machining forces, as well as a shift in cutting formation mechanism from shear to extrusion shear. The reduction in the clearance angle only increases the high-stress areas and machining forces. The stress state and dislocation density within the chip and plastic deformation zone were closely related to the tool topography. The conclusions provide a thorough technical analysis of the mechanism of polycrystalline Au nanowire formation as well as theoretical guidance for the design and selection of tools for nanoskiving processes

Rare and fatal complications of tonsillectomy: sudden pneumothorax and extensive subcutaneous emphysema

Tonsillectomy is a common, minimally invasive, and relatively safe surgical operation. Although the surgical technology for such minor operations is mature and widely available in most countries worldwide, postoperative adverse complications occur and may be hazardous and fatal. Our article presents the details of a 4-year-old boy who suddenly developed pneumothorax and systemic extensive subcutaneous emphysema after tonsillectomy. He received professional treatment from a multi-disciplinary team (MDT) and timely rescue in our hospital; however, he died tragically. To this end, there is an urgent need to raise clinicians’ awareness of the potentially fatal and rare complications that can occur after tonsillectomy

Identification of DNA repair gene signature and potential molecular subtypes in hepatocellular carcinoma

DNA repair is a critical factor in tumor progression as it impacts tumor mutational burden, genome stability, PD-L1 expression, immunotherapy response, and tumor-infiltrating lymphocytes (TILs). In this study, we present a prognostic model for hepatocellular carcinoma (HCC) that utilizes genes related to the DNA damage response (DDR). Patients were stratified based on their risk score, and groups with lower risk scores demonstrated better survival rates compared to those with higher risk scores. The prognostic model’s accuracy in predicting 1-, 3-, and 5-year survival rates for HCC patients was analyzed using receiver operator curve analysis (ROC). Results showed good accuracy in predicting survival rates. Additionally, we evaluated the prognostic model’s potential as an independent factor for HCC prognosis, along with tumor stage. Furthermore, nomogram was employed to determine the overall survival year of patients with HCC based on this independent factor. Gene set enrichment analysis (GSEA) revealed that in the high-risk group, apoptosis, cell cycle, MAPK, mTOR, and WNT cascades were highly enriched. We used training and validation datasets to identify potential molecular subtypes of HCC based on the expression of DDR genes. The two subtypes differed in terms of checkpoint receptors for immunity and immune cell filtration capacity.Collectively, our study identified potential biomarkers of HCC prognosis, providing novel insights into the molecular mechanisms underlying HCC