Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Patients with Acute Coronary Syndrome

The evidence for sodium-glucose cotransporter 2 inhibitors (SGLT2i) in the treatment of type 2 diabetes or chronic heart failure was sufficient but lacking in acute coronary syndrome (ACS). Our aim was to investigate the effects of SGLT2i on cardiovascular outcomes in ACS patients. Studies of SGLT2i selection in ACS patients were searched and pooled. Outcomes included all-cause death, adverse cardiovascular events, cardiac remodeling as measured by the left ventricular end-diastolic dimension (LVEDD) and left ventricular end-systolic dimension (LVESD), cardiac function as assessed by the left ventricular ejection fraction (LVEF) and NT-proBNP, and glycemic control. Twenty-four studies with 12,413 patients were identified. Compared to the group without SGLT2i, SGLT2i showed benefits in reducing all-cause death (OR 0.72, 95% CI [0.61, 0.85]), major adverse cardiovascular events (MACE) (OR 0.44, 95% CI [0.30, 0.64]), cardiovascular death (OR 0.66, 95% CI [0.54, 0.81]), heart failure (OR 0.52, 95% CI [0.44, 0.62]), myocardial infarction (OR 0.68, 95% CI [0.56, 0.83]), angina pectoris (OR 0.37, 95% CI [0.17, 0.78]), and stroke (OR 0.48, 95% CI [0.24, 0.96]). Results favored SGLT2i for LVEDD (MD −2.03, 95% CI [−3.29, −0.77]), LVEF (MD 3.22, 95% CI [1.71, 4.72]), and NT-proBNP (MD −171.53, 95% CI [−260.98, −82.08]). Thus, SGLT2i treatment reduces the risk of all-cause death and MACE and improves cardiac remodeling and function in ACS patients

Supplementary document for Layer-dependent excitonic valley polarization properties in MoS2-WS2 heterostructures - 6099426.pdf

Supplemental Documen

Data_Sheet_1_Ag3VO4 Nanoparticles Decorated Bi2O2CO3 Micro-Flowers: An Efficient Visible-Light-Driven Photocatalyst for the Removal of Toxic Contaminants.DOC

<p>Semiconductor-based photocatalysis is of great potential for tackling the environmental pollution. Herein, a novel hierarchical heterostructure of Bi₂O₂CO₃ micro-flowers in-situ decorated with Ag₃VO₄ nanoparticles was developed by a facile method. Various characterization techniques have been employed to study the physical and chemical property of the novel catalyst. The novel catalyst was utilized for the photocatalytic removal of industrial dyes (rhodamine B, methyl orange) and tetracycline antibiotic under visible-light irradiation. The results indicated that Ag₃VO₄/Bi₂O₂CO₃ heterojunctions showed a remarkably enhanced activity, significantly higher than those of bare Ag₃VO₄, Bi₂O₂CO₃, and the physical mixture of Ag₃VO₄ and Bi₂O₂CO₃ samples. This could be ascribed to an enhanced visible-light harvesting capacity and effective separation of charge carriers by virtue of the construction of hierarchical Ag₃VO₄/Bi₂O₂CO₃ heterojunction. Moreover, Ag₃VO₄/Bi₂O₂CO₃ also possesses an excellent cycling stability. The outstanding performance of Ag₃VO₄/Bi₂O₂CO₃ in removal of toxic pollutants indicates the potential of Ag₃VO₄/Bi₂O₂CO₃ in real environmental remediation.</p><p>Highlights</p><p>Novel architectures of Ag₃VO₄ nanoparticles modified Bi₂O₂CO₃ micro-flowers were constructed.</p><p>Novel Ag₃VO₄/Bi₂O₂CO₃ exhibited excellent photocatalytic activity and stability.</p><p>Ag₃VO₄/Bi₂O₂CO₃ heterojunctions significantly promote the charge separation.</p><p></p

Preparation of highly purified timosaponin AIII from rhizoma anemarrhenae through an enzymatic method combined with preparative liquid chromatography

<p>Timosaponin AIII (TAIII) exhibits extensive pharmacological activities and has been reported as a potent antitumour agent for various human cancers. In the present study, a potential industrial process for producing TAIII that involves biotransformation directly in the crude extract liquid of rhizoma anemarrhenae (RA) was developed. <i>β</i>-D-glycosidase was used to transform timosaponin BII (TBII) into TAIII, and monofactor experiments were conducted to optimise the enzymolysis conditions. In addition, AB-8 macroporous resin column chromatography, preparative liquid chromatography, and crystallisation technique were applied for yielding TAIII crystals with a purity > 97%. Approximately, 7 g of TAIII with a high purity of > 97% was obtained from 1 kg of RA through this five-step preparation method, which can be used to produce TAIII on a large scale.</p

Highly Efficient Room-Temperature Phosphorescence from Halogen-Bonding-Assisted Doped Organic Crystals

The development of metal-free organic room temperature phosphorescence (RTP) materials has attracted increasing attention because of their applications in sensors, biolabeling (imaging) agents and anticounterfeiting technology, but remains extremely challenging owing to the restricted spin-flip intersystem crossing (ISC) followed by low-yield phosphorescence that cannot compete with nonradiative relaxation processes. Here, we report a facile strategy to realize highly efficient RTP by doping iodo difluoroboron dibenzoylmethane (I-BF₂dbm-R) derivatives into a rigid crystalline 4-iodobenzonitrile (Iph-CN) matrix. We found that halogen bonding between cyano group of Iph-CN matrix and iodine atom of I-BF₂dbm-R dopant is formed in doped crystals, i.e., Iph-CN···I-BF₂dbm-R, which not only suppresses nonradiative relaxation of triplets but also promotes the spin–orbit coupling (SOC). As a result, the doped crystals show intense RTP with an efficiency up to 62.3%. By varying the substituent group R in I-BF₂dbm-R from electron donating −OCH₃ to electron accepting −F, −CN groups, the ratio between phosphorescence and fluorescence intensities has been systematically increased from 3.8, 15, to 50

Highly Efficient Room-Temperature Phosphorescence from Halogen-Bonding-Assisted Doped Organic Crystals

The development of metal-free organic room temperature phosphorescence (RTP) materials has attracted increasing attention because of their applications in sensors, biolabeling (imaging) agents and anticounterfeiting technology, but remains extremely challenging owing to the restricted spin-flip intersystem crossing (ISC) followed by low-yield phosphorescence that cannot compete with nonradiative relaxation processes. Here, we report a facile strategy to realize highly efficient RTP by doping iodo difluoroboron dibenzoylmethane (I-BF₂dbm-R) derivatives into a rigid crystalline 4-iodobenzonitrile (Iph-CN) matrix. We found that halogen bonding between cyano group of Iph-CN matrix and iodine atom of I-BF₂dbm-R dopant is formed in doped crystals, i.e., Iph-CN···I-BF₂dbm-R, which not only suppresses nonradiative relaxation of triplets but also promotes the spin–orbit coupling (SOC). As a result, the doped crystals show intense RTP with an efficiency up to 62.3%. By varying the substituent group R in I-BF₂dbm-R from electron donating −OCH₃ to electron accepting −F, −CN groups, the ratio between phosphorescence and fluorescence intensities has been systematically increased from 3.8, 15, to 50

Self-Assembly of Stimuli-Responsive Au–Pd Bimetallic Nanoflowers Based on Betulinic Acid Liposomes for Synergistic Chemo-Photothermal Cancer Therapy

Synergistic cancer therapy through the combination of chemotherapy with photothermal therapy has been gained more and more insights. Bimetallic nanostructures with near-infrared (NIR) plasmonic responses are considered prime candidates based on their superior photothermal conversion properties. Herein, novel poly branched Au–Pd bimetallic-nanoflowers-coated betulinic acid liposomes (BA-Lips@Pd@Au NFs) were designed and developed. The as-prepared BA-Lips@Pd@Au NFs with optimal size (144.4 nm) possessed good photostability under NIR-irradiation, high photothermal conversion efficiency (64.6%), and good biocompatibility. Moreover, the hyperthermia of drug delivery induced by NIR-irradiation dramatically improved the cell uptake of nanocapsules and enhanced the chemotherapeutic efficacy of tumor. Upon illumination by NIR light, the BA-Lips@Pd@Au NFs exhibited prominent synergetic effects of chemo-photothermal therapy with a tumor inhibition ratio (91.7%), which was higher than that of chemotherapy or photothermal therapy alone. Therefore, this rational design of nanocapsule with stimuli-responsive capability showed a versatile strategy to provide smart nanocapsule paradigms for cancer therapy

Magnetically Recoverable Nanoflake-Shaped Iron Oxide/Pt Heterogeneous Catalysts and Their Excellent Catalytic Performance in the Hydrogenation Reaction

In this study, a kind of unique Fe₂O₃/Pt hybrid consisting of uniform platinum nanoparticles deposited on a nanoflake-shaped Fe₂O₃ support was prepared by using a solvothermal reaction followed by a heat-induced reduction process. The prepared Fe₂O₃ sample displays well-defined nanoflake-like morphology; remarkably, there are many specific cavities on its surface. In addition, uniform Pt nanoparticles with narrow size distribution were deposited onto the surface of the preformed flake-like Fe₂O₃ support to form the Fe₂O₃/Pt hybrid via a facile heat-induced reduction reaction. Thus, the prepared Fe₂O₃/Pt hybrid can serve as heterogeneous catalyst over the hydrogenation reaction. Results demonstrated that the specific Fe₂O₃/Pt heterogeneous catalyst exhibits good catalytic performances, including high conversion, specific selectivity, and excellent recycling durability, over hydrogenation reactions for different substrates. Furthermore, the prepared Fe₂O₃/Pt heterogeneous catalyst could be easily separated from the product mixture by using a magnet and could be recycled for 10 cycles without catalytic activity loss. In a word, the present synthetic approach is facile, scalable, and reproducible, which can be easily facilitated to prepare other types of noble metals/metal oxide composite systems

Enhanced Homogeneity of Moiré Superlattices in Double-Bilayer WSe₂ Homostructure

Moiré superlattices have emerged as a promising platform for investigating and designing optically generated excitonic properties. The electronic band structure of these systems can be qualitatively modulated by interactions between the top and bottom layers, leading to the emergence of new quantum phenomena. However, the inhomogeneities present in atomically thin bilayer moiré superlattices created by artificial stacking have hindered a deeper understanding of strongly correlated electron properties. In this work, we report the fabrication of homogeneous moiré superlattices with controllable twist angles using a 2L-WSe2/2L-WSe2 homostructure. By adding extra layers, we provide additional degrees of freedom to tune the optical properties of the moiré superlattices while mitigating the nonuniformity problem. The presence of an additional bottom layer acts as a buffer, reducing the inhomogeneity of the moiré superlattice, while the encapsulation effect of the additional top and bottom WSe2 monolayers further enhances the localized moiré excitons. Our observations of alternating circularly polarized photoluminescence confirm the existence of moiré excitons, and their characteristics were further confirmed by theoretical calculations. These findings provide a fundamental basis for studying moiré potential correlated quantum phenomena and pave the way for their application in quantum optical devices

Absence of Intramolecular Singlet Fission in Pentacene–Perylenediimide Heterodimers: The Role of Charge Transfer State

A new class of donor–acceptor heterodimers based on two singlet fission (SF)-active chromophores, i.e., pentacene (Pc) and perylenediimide (PDI), was developed to investigate the role of charge transfer (CT) state on the excitonic dynamics. The CT state is efficiently generated upon photoexcitation. However, the resulting CT state decays to different energy states depending on the energy levels of the CT state. It undergoes extremely rapid deactivation to the ground state in polar CH₂Cl₂, whereas it undergoes transformation to a Pc triplet in nonpolar toluene. The efficient triplet generation in toluene is not due to SF but CT-mediated intersystem crossing. In light of the energy landscape, it is suggested that the deep energy level of the CT state relative to that of the triplet pair state makes the CT state actually serve as a trap state that cannot undergoes an intramolecular singlet fission process. These results provide guidance for the design of SF materials and highlight the requisite for more widely applicable design principles