Additional file 1: of Double-adjustment in propensity score matching analysis: choosing a threshold for considering residual imbalance

‘Supplementary material: simulation design’. Variable definitions and coefficients for data generation (Table S1 and Table S2), and variable relationships and correlations (Figure S1). (DOCX 143 kb

Survival curves for mortality, re-hospitalization, and re-fracture.

<p>Survival curves for mortality, re-hospitalization, and re-fracture for patients in the orthopedic (solid lines) and geriatric (dotted line) cohorts. Survival is non-adjusted (panels A, C, and E) and adjusted (panels B, D, and F) for age, sex and Cumulative Illness Rating Scale (CIRS) calculated with a Cox regression analysis. For re-hospitalization and re-fracture, death was considered as a censored observation. <i>P</i> values refer to log-rank test.</p

Comparison of the main characteristics of the two study cohorts.

<p>Data are mean ± SD, median [25–75 interquartile], or number (percentage). COPD: chronic obstructive pulmonary disease; CIRS: cumulative illness rating scale;</p><p>^a : defined as body mass index >30 kg.m⁻²;</p><p>^b : creatinine clearance could be calculated in 99 (76%) and 200 (98%) patients in the orthopedic and geriatric cohorts respectively.</p><p>: P<0.05 vs Orthopedic cohort.</p

Transfers and allocation of patients.

<p>Evolution of transfers out of the hospital (n = 392) and allocation to the orthopedic (n = 131) and geriatric (n = 203) cohorts during the study period. There were only 4 months (September to December) in 2005 and 3 months (January to March) in 2012.</p

Acute care, rehabilitation, and walking ability.

<p>Data are mean ± SD, median [25–75 interquartile], or number (percentage). LOS: length of stay; ICU: intensive care unit;</p><p>^a : excluding death during acute care;</p><p>^b : institution was considered as “home” in patients previously living in an institution;</p><p>^c : excluding patients previously living in an institution;</p><p>^d : excluding patients who died in acute care and/or rehabilitation.</p

Survival curves for in-hospital mortality.

<p>Survival curves for in-hospital mortality in the geriatric (Panel A) and orthopedic (Panel B) cohorts, and their respective matched cohorts from the national registry. <i>P</i> values refer to log-rank test.</p

Multivariate cox proportional-hazards analysis predicting death, re-fracture, and re-hospitalization.

<p>CI: confidence interval; CIRS: cumulative illness rating scale;</p><p>^a : only patients who survived to acute care and rehabilitation were considered;</p><p>^b : only patients who were not previously living in an institution were considered. For re-hospitalization and re-fracture, death was considered as a censored observation.</p

Impact of aspirin withdrawal and reintroduction on arachidonic acid-induced platelet aggregation.

<p>D-5: baseline value determined during preoperative examination. Ds: day of surgery. D+7: seven days after surgery, five days after aspirin resumption Arachidonic acid was used at 2 mM. Platelet aggregation is expressed as maximal aggregation (%).</p

Flowchart of the study.

<p>Flowchart of the study.</p

Patients’ characteristics.

<p>Data are presented as the mean value ± SD or number (%) of subjects. RCRI: Revised Cardiac Risk Index; ACE: angiotensin converting enzyme. CI = confidence interval.</p