Thickness of capsule contracture tissue samples (y-axis, mm) after incubation with different doses of collagenase (x-axis, mg/ml) in correlation to capsule density (<20%, black and 20–40%, white).

<p>Thickness of capsule contracture tissue samples (y-axis, mm) after incubation with different doses of collagenase (x-axis, mg/ml) in correlation to capsule density (<20%, black and 20–40%, white).</p

Density of capsule contracture tissue samples (y-axis, %) after incubation with different doses of collagenase (x-axis, mg/ml).

<p>Brackets indicate statistically significant differences (p<0.05).</p

Collagen concentration of capsule contracture tissue samples (y-axis, μg/gr. Tissue) after incubation with different doses of collagenase (x-axis, mg/ml).

<p>Brackets indicate statistically significant differences (p<0.05).</p

Custom-made titanium chamber for incubation of capsular contracture tissue and full thickness breast skin samples with 4 different doses of collagenase.

<p>Custom-made titanium chamber for incubation of capsular contracture tissue and full thickness breast skin samples with 4 different doses of collagenase.</p

Thickness of capsule contracture tissue samples (y-axis, mm) after incubation with different doses of collagenase (x-axis, mg/ml).

<p>Brackets indicate statistically significant differences (p<0.05).</p

Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue - Fig 6

<p>Example pictures of Picro Sirius red staining under light microscopy, circularly polarized light microscopy and immunohistochemistry staining for collagen 2 and 4 (from top to bottom) of capsule contracture tissue after incubation with 0.0, 0.3, 0.9, and 1.8mg/ml of collagenase (from left to right). After collagenase incubation only collagen 4 is detectable in immunohistology all other collagen subtypes were successfully digested.</p

Example pictures of picrosirius red staining under polarized light of both study groups on day 60.

<p>Example pictures of picrosirius red staining under polarized light of both study groups on day 60.</p

Mean (+/- standard deviation) capsule volume in MRI of each study group.

<p>Results were not statistically significant.</p

Example pictures of MR images for volumetric measurements.

<p>From top to bottom: Blank slides, complete capsule volume (green), implant volume (red) and complete minus implant volume (green margin). Volume calculations were performed via VOLUMEST and the scale was adjusted automatically by the software.</p

Mean (+/- standard deviation) capsule thickness in MRI of each study group.

<p>Results were not statistically significant.</p