1 research outputs found
Assembly of 3‑Sulfenylbenzofurans and 3‑Sulfenylindoles by Palladium-Catalyzed Cascade Annulation/Arylthiolation Reaction
A novel
and efficient palladium-catalyzed cascade annulation/arylthiolation
reaction has been developed to afford functionalized 3-sulfenylbenzofuran
and 3-sulfenylindole derivatives in moderate to good yields from readily
available 2-alkynylphenols and 2-alkynylamines in ionic liquids. This
protocol provides a valuable synthetic tool for the assembly of a
wide range of 3-sulfenylbenzofuran and 3-sulfenylindole derivatives
with high atom- and step-economy and exceptional functional group
tolerance. Moreover, the employment of ionic liquids under mild reaction
conditions makes this transformation green and practical. Furthermore,
this approach enriched current C–S bond formation chemistry,
making a valuable and practical method in synthetic and medicinal
chemistry