Three new triterpenoid saponins from the roots of <i>Ardisia crenata</i> and their cytotoxic activities

<p>Three new triterpenoid saponins, ardisicrenoside <b>O</b> (<b>1</b>), ardisicrenoside <b>P</b> (<b>2</b>) and ardisicrenoside <b>Q</b> (<b>3</b>) together with three known compounds, 3β,16α-dihydroxy-30-methoxy-28, 30-epoxy-olean-12-en, cyclamiretin A 3-O-β-d-glucopyranosyl-(1→2) -α-l-arabinopyranoside and cyclamiretin A 3-<i>O</i>-β-d-glucopyranosyl-(1→4) -α-l-arabinopyranoside were isolated from the roots of <i>Ardisia crenata</i> Sims. Their structures were determined by one- and two-dimensional NMR techniques, including HSQC, HMBC and TOCSY experiments, as well as acid hydrolysis and GC analysis. All isolates were evaluated for the cytotoxic activities on two human cancer cell lines and compounds <b>3, 5</b> and <b>6</b> showed significant cytotoxicity.</p

Survival of subgroups stratified by MRD at CR1 in the chemotherapy arm.

<p>(A) OS and (B) LFS of subgroups stratified by MRD at CR1 in the chemotherapy arm.</p

Multivariate analysis for relapse and OS in the allo-HSCT arm.

<p>Multivariate analysis for relapse and OS in the allo-HSCT arm.</p

Patient Flow Diagram.

<p>Patient Flow Diagram.</p

Patient Characteristics.

<p>Patient Characteristics.</p

sj-docx-1-cll-10.1177_09636897231225821 – Supplemental material for Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients With Acute Myeloid Leukemia Harboring KMT2A Rearrangement and Its Prognostic Factors

Supplemental material, sj-docx-1-cll-10.1177_09636897231225821 for Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients With Acute Myeloid Leukemia Harboring KMT2A Rearrangement and Its Prognostic Factors by Bingqian Jiang, Yanmin Zhao, Yi Luo, Jian Yu, Yi Chen, Baodong Ye, Huarui Fu, Xiaoyu Lai, Lizhen Liu, Yishan Ye, Weiyan Zheng, Jie Sun, Jingsong He, Yi Zhao, Guoqing Wei, Zhen Cai, He Huang and Jimin Shi in Cell Transplantation</p