8 research outputs found
A New Similarity Metric for Groupwise Registration of Variable Flip Angle Sequences for Improved T 10 Estimation in DCE-MRI
Selection and validation of predictive models of radiation effects on tumor growth based on noninvasive imaging data
Valutazione mediante tomografia computerizzata perfusionale del tessuto cerebrale circostante lâarea lesionale dâimpregnazione nei gliomi ad alto grado
The ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): Results from the OSIPIâDynamic Contrast-Enhanced challenge
Purpose: K trans has often been proposed as a quantitative imaging biomarker for diagnosis,prognosis,andtreatmentresponseassessmentforvarioustumors.Noneofthe many software tools for K trans quantification are standardized. The ISMRM OpenScience Initiative for Perfusion ImagingâDynamic Contrast-Enhanced (OSIPI-DCE)challenge was designed to benchmark methods to better help the efforts to standardize K trans measurement.
Methods: A framework was created to evaluate K trans values produced by DCE-MRI analysis pipelines to enable benchmarking. The perfusion MRI community was invited to apply their pipelines for K trans quantification in glioblastoma from clinical and synthetic patients. Submissions were required to include the entrantsâ K trans values, the applied software, and a standard operating procedure. These were evaluated using the proposed OSIPIgold score defined with accuracy, repeatability, and reproducibility components.
Results: Across the 10 received submissions, the OSIPIgold score ranged from28% to 78% with a 59% median. The accuracy, repeatability, and reproducibility scores ranged from 0.54 to 0.92, 0.64 to 0.86, and 0.65 to 1.00, respectively(0â1=lowestâhighest). Manual arterial input function selection markedly affected the reproducibility and showed greater variability in K trans analysis than automated methods. Furthermore, provision of a detailed standard operating procedure was critical for higher reproducibility.
Conclusions: This study reports results from the OSIPI-DCE challenge and high-lights the high inter-software variability within K trans estimation, providing a framework for ongoing benchmarking against the scores presented. Through this challenge, the participating teams were ranked based on the performance of their software tools in the particular setting of this challenge. In a real-world clinical setting, many of these tools may perform differently with different benchmarking methodology