Moving forward in HIV-associated cancer

Cancer has been linked to HIV since the earliest days of the epidemic. The unusually frequent occurrence of Kaposi sarcoma (KS) among men who have sex with men (MSM) in 1981 was a sentinel observation leading to the inclusion of KS in the first AIDS case definition.1,2 More than three decades later, major research investments have led to striking advances in understanding HIV pathogenesis, with antiretroviral therapy (ART) reducing AIDS complications and allowing HIV-infected individuals to experience life expectancy approaching that of persons without HIV

Reply to P. de Paoli et al

Weare grateful for the correspondence provided by De Paoli and Carbone1 regarding our recently published Comments and Controversies piece focused on HIV-associated cancers. Their letter provides an important extension of some of the main points articulated in our article. Indeed, we wish to acknowledge our correspondents’ own excellent review also highlighting the complexity and heterogeneity of cancers occurring in the HIV-infected populatio