BIOMECHANICAL ANALYSIS OF RIGHT SIDEDSTRIDE IN JAVELIN DELIVERY

The purpose of this study was to analyze the technique of javelin delivery using a rightsided stride. This study provided important data for more accurate analysis of the technique of javelin throwing with the right-sided delivery stride. The performance of 10 Chinese elite javelin throwers were filmed and then, some relevant parameters were analyzed. Based on these measurements, it was found that the right foot turns outward when contacting the ground, while the right knee is slightly flexed in the delivery stride. However the strength of the right leg depends on extension of right hip rather than that of right knee

Wind turbine asymmetrical load reduction with pitch sensor fault compensation

Offshore wind turbines suffer from asymmetrical loading (blades, tower, etc), leading to enhanced structural fatigue. As well as asymmetrical loading different faults (pitch system faults etc.) can occur simultaneously, causing degradation of load mitigation performance. Individual pitch control (IPC) can achieve rotor asymmetric loads mitigation, but this is accompanied by an enhancement of pitch movements leading to the increased possibility of pitch system faults, which exerts negative effects on the IPC performance. The combined effects of asymmetrical blade and tower bending together with pitch sensor faults are considered as a “co‐design” problem to minimize performance deterioration and enhance wind turbine sustainability. The essential concept is to attempt to account for all the “fault effects” in the rotor and tower systems, which can weaken the load reduction performance through IPC. Pitch sensor faults are compensated by the proposed fault‐tolerant control (FTC) strategy to attenuate the fault effects acting in the control system. The work thus constitutes a combination of IPC‐based load mitigation and FTC acting at the pitch system level. A linear quadratic regulator (LQR)‐based IPC strategy for simultaneous blade and tower loading mitigation is proposed in which the robust fault estimation is achieved using an unknown input observer (UIO), considering four different pitch sensor faults. The analysis of the combined UIO‐based FTC scheme with the LQR‐based IPC is shown to verify the robustness and effectiveness of these two systems acting together and separately

Actuator fault tolerant offshore wind turbine load mitigation control

Offshore wind turbine (OWT) rotors have large diameters with flexible blade structures which are subject to asymmetrical loads caused by blade flapping and turbulent or unsteady wind flow. Rotor imbalance inevitably leads to enhanced fatigue of blade rotor hub and tower structures. Hence, to enhance the life of the OWT and maintain good power conversion the unbalanced loading requires a reliable mitigation strategy, typically using a combination of Individual Pitch Control (IPC) and Collective Pitch Control (CPC). Increased pitch motion resulting from IPC activity can increase the possibility of pitch actuator faults and the resulting load imbalance results in loss of power and enhanced fatigue. This has accelerated the emergence of new research areas combining IPC with the fault tolerant control (FTC)-based fault compensation, a so-called FTC and IPC “co-design” system. A related research challenge is the clear need to enhance the robustness of the FTC IPC “co-design” to some dynamic uncertainty and unwanted disturbance. In this work a Bayesian optimization-based pitch controller using Proportional–Integral (PI) control is proposed to improve pitch control robustness. This is achieved using a systematic search for optimal controller coefficients by evaluating a Gaussian process model between the designed objective function and the coefficients. The pitch actuator faults are estimated and compensated using a robust unknown input observer (UIO)-based FTC scheme. The robustness and effectiveness of this “co-design” scheme are verified using Monte Carlo simulations applied to the 5MW NREL FAST WT benchmark system. The results show clearly (a) the effectiveness of the load mitigation control for a wide range of wind loading conditions, (b) the effect of actuator faults on the load mitigation performance and (c) the recovery to normal load mitigation, subject to FTC action

Oxidation Analyses of Massive Air Ingress Accident of HTR-PM

The double-ended guillotine break (DEGB) of the horizontal coaxial gas duct accident is a serious air ingress accident of the high temperature gas-cooled reactor pebble-bed module (HTR-PM). Because the graphite is widely used as the structure material and the fuel element matrix of HTR-PM, the oxidation analyses of this severe air ingress accident have got enough attention in the safety analyses of the HTR-PM. The DEGB of the horizontal coaxial gas duct accident is calculated by using the TINTE code in this paper. The results show that the maximum local oxidation of the matrix graphite of spherical fuel elements in the core will firstly reach 3.75⁎104 mol/m3 at about 120 h, which means that only the outer 5 mm fuel-free zone of matrix graphite will be oxidized out. Even at 150 h, the maximum local weight loss ratio of the nuclear grade graphite in the bottom reflectors is only 0.26. Besides, there is enough time to carry out some countermeasures to stop the air ingress during several days. Therefore, the nuclear grade graphite of the bottom reflectors will not be fractured in the DEGB of the horizontal coaxial gas duct accident and the integrity of the HTR-PM can be guaranteed

Bis[2-(benzyl­idene­amino)­phen­yl] disulfide

In the title mol­ecule, C26H20N2S2, the two benzene rings connected by a disulfide chain form a dihedral angle of 84.9 (1)°, and the two benzene rings in the two benzyl­idene­amino­phenyl fragments form dihedral angles of 34.4 (1) and 32.8 (1)°. The crystal structure exhibits weak inter­molecular C—H⋯S hydrogen bonds, which link the mol­ecules into chains along [101]

Mechanism and Role of Tumor Microenvironment in the Initiation and Progression of Bladder Cancer

Tumor microenvironment (TME) is a huge network, composed by tumor cells, tumor associated stromal cells, immune cells, cytokines and chemokines secreted by these cells, in which various cells communicate with each other. Bladder cancer is characterized of tendency of relapse, progression, metastasis because of the role of TME. With the application and development of new technologies recently, such as tumor bulk RNA-sequencing and singlecell transcriptome sequencing, the composition of TME for bladder cancer is increasingly clear and the complex cell-to-cell communication network is fully duged, which provides a new vision for the therapy of bladder cancer. This paper reviewed and further analysed the research hotspots of cellular components and extracellular matrix components of bladder cancer on the basis of the latest research progress

Application of evolution-based uncertainty design on gear

The evolution of mechanical parameters, a factor affecting the mechanical reliability, has gathered more attention nowadays. However, studies on time varying uncertainty can hardly be found. A new method based on evolution-based uncertainty design (EBUD) is applied to the design of gear in this paper. Considering the wear evolution over the lifetime, a tooth wear’s time-varying uncertainty model based on the continuous-time model and Ito lemma is established. Drift and volatility functions dependent on the drift rate and volatility rate of rotational speed and torque are used to express the time-varying uncertainty of tooth thickness. The method can predict the reliability and provide an instruction in reliability improving, maintenance and repair of the gear system

Legume Lectin FRIL Preserves Neural Progenitor Cells in Suspension Culture In Vitro

In vitro maintenance of stem cells is crucial for many clinical applications. Stem cell preservation factor FRIL (Flt3 receptor-interacting lectin) is a plant lectin extracted from Dolichos Lablab and has been found preserve hematopoietic stem cells in vitro for a month in our previous studies. To investigate whether FRIL can preserve neural progenitor cells (NPCs), it was supplemented into serum-free suspension culture media. FRIL made NPC grow slowly, induced cell adhesion, and delayed neurospheres formation. However, FRIL did not initiate NPC differentiation according to immunofluorescence and semiquantitive RT-PCR results. In conclusion, FRIL could also preserve neural progenitor cells in vitro by inhibiting both cell proliferation and differentiation