Screen shots showing DNA methylation query by Gene symbol GSTP1 in human.

<p>A, the search form page in which the exclusion relationship between Refseq ID, Gene symbol, and Location is indicated. B, the query result page embedded with the link to track view in UCSC genome browser. C, the details page showing supportive references and DNA methylation loci in a graph.</p

Number of epigenetic records and genes in PEpiD, with gene numbers in parentheses.

<p>Number of epigenetic records and genes in PEpiD, with gene numbers in parentheses.</p

Association of gene expression with histone modifications in drug-resistance isograft samples (LLC-R).

<p>Association of gene expression with histone modifications in drug-resistance isograft samples (LLC-R).</p

Map of Henan Province, showing laboratory-confirmed FTLS cases in 2011–2012.

<p>1 Shangcheng, 2 Guangshan, 3 Sihe), 4 Pingqiao, 5 Xinxian, 6 Luoshan, 7 Gushi, 8 Huangchuan, 9 Tongbai, 10 Xixian, 11 Queshan, 12 Luyi, 13 Zhengyang, 14 Dengfeng.</p

Histone modification levels are predictive for expression of genes categorized by CpG level in promoter.

<p>(A) Composition of all promoters classified by histone modification occupancy. “Active” promoters contain occupancy of the active histone marks (H3K4me3 or H3K9ac) higher than the average level of all promoters but occupancy of the repressive histone mark (H3K27me3) lower than the average level. “Repressive” promoters contain occupancy of H3K27me3 higher than the average level and are exclusive of the “active” promoters. “Bivalent” promoters contain occupancy of H3K4me3 or H3K9ac higher than the average level and occupancy of H3K27me3 higher than the average level. “None” promoters are the rest. (B) Box plots show expression levels of genes in each category in (A). (** <i>p</i>-value ≤ 0.01, * <i>p</i>-value ≤ 0.05, n.s. <i>p</i>-value > 0.05, Student’s <i>t</i> test.) (C) H3K36me3 profiles in different sets of genes classified in (A). HCP: CpG-rich promoters, ICP: intermediate-CpG-level promoters, LCP CpG-poor promoters.</p

The GenBank accession numbers of SFTSV obtained in this study.

<p>The GenBank accession numbers of SFTSV obtained in this study.</p

Correlation of histone modification profiles at all promoters and gene expression.

<p>The scatter plots show the correlation in LLC-NR sample (A) and LLC-R sample (B), respectively. The Spearman correlation coefficients are shown.</p

Phylogenetic analysis of FTLSV strains isolated from Henan Province during 2011 and 2012, compared with other bunyaviruses.

<p>The phylogenetic tree was constructed by using the maximum likelihood method with the MEGA5 software. The reliability values indicated at the branch nodes were determined using 1,000 bootstrap replications. Isolated FTLSV strains in 2011 and 2012 from Henan Province were labeled by black solid triangles. Phylogenetic relationship of FTLSV with other bunyaviruses, based on the complete L, M, S segment sequences, are shown in panel A, B, C, respectively.</p

Monthly distribution of reported FTLS cases: Henan Province, China, January 2011 to December 2012.

<p>Monthly distribution of reported FTLS cases: Henan Province, China, January 2011 to December 2012.</p

Sequences of FTLSV with associated location of origin, collection dates, host and GenBank accession numbers.

<p>Sequences of FTLSV with associated location of origin, collection dates, host and GenBank accession numbers.</p