Effects of Post Treatments on Bismuth-Doped and Bismuth/ Erbium Co-doped Optical Fibres

Bismuth-doped and bismuth/erbium co-doped optical fibres have attracted much attention for their great potential in the photonic applications at ultrawide O, E, S, C and L bands. The effects of post treatments, including various heating, high energy ray radiation, laser radiation and H2 loading processes, on these fibres’ performance, functionality and stability have been experimentally studied. Experimental results demonstrate that these post treatments could allow us to get insights regarding the formation and the structure of bismuth active centre (BAC) and be used to control and regulate the formation of BAC

Mechanism and Role of Tumor Microenvironment in the Initiation and Progression of Bladder Cancer

Tumor microenvironment (TME) is a huge network, composed by tumor cells, tumor associated stromal cells, immune cells, cytokines and chemokines secreted by these cells, in which various cells communicate with each other. Bladder cancer is characterized of tendency of relapse, progression, metastasis because of the role of TME. With the application and development of new technologies recently, such as tumor bulk RNA-sequencing and singlecell transcriptome sequencing, the composition of TME for bladder cancer is increasingly clear and the complex cell-to-cell communication network is fully duged, which provides a new vision for the therapy of bladder cancer. This paper reviewed and further analysed the research hotspots of cellular components and extracellular matrix components of bladder cancer on the basis of the latest research progress

High intrinsic sensitivity etched polymer fiber Bragg grating pair for simultaneous strain and temperature measurements

A sensing configuration for simultaneous measurement of strain and temperature with enhanced intrinsic sensitivity based on a fiber Bragg grating (FBG) pair with one grating inscribed in the etched and the other in unetched polymer fiber region is demonstrated. A poly (methyl methacrylate) based single-mode polymer fiber is etched to different diameters, and it is observed that etching can lead to change in the material properties of the fiber, such as Young\u27s modulus and thermal expansion coefficient, which can play a vital role in improving its intrinsic sensing capabilities. Thus, exploiting the different strain and temperature sensitivities exhibited by etched and unetched polymer FBGs, strain and temperature can be simultaneously measured with very high sensitivity. Experimental results show that rms deviations of ±8.42 μ∈ and ±0.39 °C for strain and temperature, respectively, in a real simultaneous measurement. The effect of individual thermal and strain sensitivity coefficients on measurement accuracy is also analyzed

Radiation Effect on Optical Properties of Bi-Related Materials Co-Doped Silica Optical Fibers

Three kinds of Bi-related materials co-doped silica optical fibers (BRDFs), including Bi/Al, Bi/Pb, and Bi/Er co-doped fibers, were fabricated using atomic layer deposition (ALD) and modified chemical vapor deposition (MCVD). Then, the effect of irradiation on the optical properties of BRDFs was investigated. The experimental results showed that the fluorescence intensity, the fluorescence lifetime of BRDFs at the 1150 nm band, increased significantly with low-dose treatment, whereas it decreased with a further increase in the radiation dose. In addition, the merit Mα values of the BRDFs, a ratio of useful pump absorption to total pump absorption, decreased with an increase of the radiation doses. The Verdet constants of different doped fibers increased up to saturation level with increases in the radiation dose. However, for a Bi-doped fiber, its Verdet constant decreased and the direction of Faraday’s rotation changed under low-dose radiation treatment. In addition, the Verdet constant increase of the Bi-doped silica fiber was much faster than that of other single mode fiber (SMF) and Pb-doped silica fibers treated with high-dose radiation. All of these findings are of great significance for the study of the optical properties of BRDFs

Molecular Characterization and Expression Profile Analysis of Heat Shock Transcription Factors in Mungbean

Heat shock transcription factors (Hsfs) are essential elements in plant signal transduction pathways that mediate gene expression in response to various abiotic stresses. Mungbean (Vigna radiata) is an important crop worldwide. The emergence of a genome database now allows for functional analysis of mungbean genes. In this study, we dissect the mungbean Hsfs using genome-wide identification and expression profiles. We characterized a total of 24 VrHsf genes and classified them into three groups (A, B, and C) based on their phylogeny and conserved domain structures. All VrHsf genes exhibit highly conserved exon-intron organization, with two exons and one intron. In addition, all VrHsf proteins contain 16 distinct motifs. Chromosome location analysis revealed that VrHsf genes are located on 8 of the 11 mungbean chromosomes, and that seven duplicated gene pairs had formed among them. Moreover, transcription patterns of VrHsf genes varied in different tissues, indicating their different roles in plant growth and development. We identified multiple stress related cis-elements in VrHsf promoter regions 2 kb upstream of the translation initiation codons, and the expression of most VrHsf genes was altered under different stress conditions, suggesting their potential functions in stress resistance pathways. These molecular characterization and expression profile analyses of VrHsf genes provide essential information for further function investigation

BAC Photobleaching in Bismuth-Doped and Bismuth/Erbium Co-Doped Optical Fibers

Bismuth-doped optical fiber (BDF) and bismuth/erbium co-doped optical fiber (BEDF) have attracted much attention due to their ultra-broadband luminescence in the near-infrared (NIR) region. The photobleaching effect on bismuth active centers (BACs) related to the NIR luminescence has been systematically investigated and summarized, in terms of irradiation intensity, irradiation wavelength, and temperature. All these findings not only give the deep insights into the fundamental structure of BACs but also provide an effective way to control the BACs. They play an important role for the development of BDF- and BEDF-based devices with high performance and stability under laser exposure in future

Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation

Endogenous retroviruses (ERVs) are subject to transcriptional repression in adult tissues, in part to prevent autoimmune responses. However, little is known about the epigenetic silencing of ERV expression. Here, we describe a new role for inhibitor of growth family member 3 (ING3), to add to an emerging group of ERV transcriptional regulators. Our results show that ING3 binds to several ERV promoters (for instance MER21C) and establishes an EZH2-mediated H3K27 trimethylation modification. Loss of ING3 leads to decreases of H3K27 trimethylation enrichment at ERVs, induction of MDA5-MAVS-interferon signaling, and functional inhibition of several virus infections. These data demonstrate an important new function of ING3 in ERV silencing and contributing to innate immune regulation in somatic cells