Fluorescent Hydrogen-Bonded Organic Framework for Sensing of Aromatic Compounds

A fluorescent hydrogen-bonded organic framework, HOF-1111, was designed and fabricated by using fluorescent tetraphenylethylene (TPE) as building block. The HOF-1111 showed high thermal stability and 3D structure. HOF-1111 can be used for sensing of aromatic compounds via a fluorescence quenching and enhancement mechanism

Clinical and metabolic characteristics of patients according to TG/HDL-C tertiles.

<p>Clinical and metabolic characteristics of patients according to TG/HDL-C tertiles.</p

The relationship with insulin resistance of each combination of TG/HDL-C tertiles and WC quartiles.

<p>Each block of OR represents the OR as against the OR which the patients belonging to the first tertile of TG/HDL-C and the first quartile of WC. Abbreviations: WC:waist circumference; T:tertile; Q:quartile.</p

Association between Triglyceride to HDL-C Ratio (TG/HDL-C) and Insulin Resistance in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus

<div><p>Objectives</p><p>To explore the association between the triglyceride to HDL-C ratio (TG/HDL-C) and insulin resistance in Chinese patients with newly diagnosed type 2 diabetes mellitus.</p><p>Methods</p><p>Patients with newly diagnosed type 2 diabetes mellitus (272 men and 288 women) were enrolled and divided into three groups according to TG/HDL-C tertiles. Insulin resistance was defined by homeostatic model assessment of insulin resistance (HOMA-IR). Demographic information and clinical characteristics were obtained. Spearman’s correlation was used to estimate the association between TG/HDL-C and other variables. Multiple logistic regression analyses were adopted to obtain probabilities of insulin resistance. A receiver operating characteristic analysis was conducted to evaluate the ability of TG/HDL-C to discriminate insulin resistance.</p><p>Results</p><p>TG/HDL-C was associated with insulin resistance in Chinese patients with newly diagnosed T2DM (Spearman’s correlation coefficient = 0.21, P < 0.01). Patients in the higher tertiles of TG/HDL-C had significantly higher HOMA-IR values than patients in the lower tertiles [T1: 2.68(1.74–3.70); T2: 2.96(2.29–4.56); T3: 3.09(2.30–4.99)]. Multiple logistic regression analysis showed that TG/HDL-C was significantly associated with HOMA-IR, and patients in the higher TG/HDL-C tertile had a higher OR than those in the lower TG/HDL-C tertile, after adjusting for multiple covariates including indices for central obesity [T1: 1; T2: 4.02(1.86–8.71); T3: 4.30(1.99–9.29)]. Following stratification of waist circumference into quartiles, the effect of TG/HDL-C on insulin resistance remained significant irrespective of waist circumference.</p><p>Conclusions</p><p>TG/HDL-C was associated with insulin resistance independent of waist circumference. Whether it could be a surrogate marker for insulin resistance in Chinese patients with newly diagnosed type 2 diabetes mellitus still needs to be confirmed by more researches.</p></div

Multivariable-adjusted odds ratios for insulin resistance according to each tertile of TG/HDL-C.

<p>Multivariable-adjusted odds ratios for insulin resistance according to each tertile of TG/HDL-C.</p

Gender-adjusted Spearman’s correlations between TG/HDL-C and other variables.

<p>Gender-adjusted Spearman’s correlations between TG/HDL-C and other variables.</p

Receiver operating characteristic (ROC) curves of TG/HDL-C, TG, and HDL-C for insulin resistance.

<p>The area under the ROC curve ± standard error (95% CI):TG/HDL-C: 0.70 ± 0.03(0.65–0.75); TG: 0.69 ± 0.03(0.64–0.74); HDL-C: 0.37 ± 0.03(0.31–0.42). Abbreviations: TG:triglyceride; HDL-C:high-density lipoprotein cholesterol; TG/HDL-C:triglyceride to high-density lipoprotein cholesterol ratio.</p