[Cp*IrCl₂]₂‑Catalyzed Amidocarbonation of Olefins with Sulfoxonium Ylides toward Functionalized Isoindolin-1-ones

A [Cp*IrCl2]2-catalyzed amidocarbonation of olefins with sulfoxonium ylides has been developed to generate diverse biologically important isoindolin-1-ones in high efficiency under mild reaction conditions. Mechanism studies indicated that this cascade reaction was triggered by amino-iridation of the olefin unit to generate iridacycle, followed by formal migratory insertion with sulfoxonium ylides. This newly developed method features broad substrate scopes and operational simplicity

Evaluation of Antibacterial and Anti-inflammatory Activities of Less Polar Ginsenosides Produced from Polar Ginsenosides by Heat-transformation

Ginsenosides are the major active constituents in both white and red American ginseng (AG), and their pharmacological effects on central nervous, cardiovascular, and endocrine systems have been well elucidated. However, the anti-<i>Propionibacterium acnes</i> (<i>P. acnes</i>) activity of them is still unknown. In this study, 5 ginsenosides enriched fractions were obtained from the total ginsenosides extract of AG roots (TAG) by resin adsorption and heat-transformation. Resin purification decreased the total polyphenol (TP) content in the fractions. However, heat treatment increased the TP content and induced extensive conversion of the polar ginsenosides (Rg₁, Re, Rb₁, Rc, Rb₂, Rd, and Gyp XVII) to less polar compounds (Rg₂, Rg₃, Rg₆/F₄, Rs₃, and Rg₅/Rk₁). Only the heat-treated fraction from 65% methanol elution of the HP-20 column (HPHF) showed antibacterial activity against <i>P. acnes</i> (ATCC11827, MIC, 128 μg/mL; ATCC6919 MIC, 64 μg/mL), <i>S. epidermidis</i> (MIC, 4100 μg/mL) and <i>S. aureus</i> (MIC, 15000 μg/mL). In the anti-inflammatory activity assay, 10 μg/mL of HPHF significantly (<i>P</i> < 0.05) inhibited NO production in LPS-stimulated RAW264.7 cells. These results suggest that less polar ginsenosides enriched fraction HPHF obtained from AG might be useful to develop new types of antibacterial substances and new skin care cosmetics for acne prevention and therapy

Funnel plots in the context of DFS without and with trim and fill.

<p>The pseudo 95% CI is computed as part of the analysis that produces the funnel plot, and corresponds to the expected 95% CI for a given SE.</p

Main results for the meta-analysis between FOXP3 expression and clinicopathological parameters.

<p>OR, odds ratio; CI, confidence interval; Q, heterogeneity Chi-squared; I², I-squared; ER, estrogen receptor.</p><p>Main results for the meta-analysis between FOXP3 expression and clinicopathological parameters.</p

Sensitivity analysis of DFS in the meta-analysis.

<p>Sensitivity analysis of DFS in the meta-analysis.</p

Funnel plots in the context of OS without and with trim and fill.

<p>The pseudo 95% CI is computed as part of the analysis that produces the funnel plot, and corresponds to the expected 95% CI for a given SE.</p

Newcastle—Ottawa quality assessment scale.

<p>BC: breast cancer.</p><p>Newcastle—Ottawa quality assessment scale.</p

Antioxidant and Antidiabetic Activities of Black Mung Bean (Vigna radiata L.)

Interest in mung bean as a functional food is growing. The objective of this study was to characterize the phenolic compounds, antioxidant activities, and antidiabetic activities of black mung beans. Five black mung beans were selected, and one green mung bean was included for comparison. The free phenolic acid and bound phenolic acid contents ranged from 16.68 to 255.51 μg/g and from 2284.53 to 5363.75 μg/g, respectively, whereas the total anthocyanin contents ranged from 0 to 810.55 μg/g with cyanidin-3-glucoside as the most dominant form, respectively. Among the mung beans tested, black mug bean Xiaoqu 7110 had the highest content of bound phenolic acids and exhibited the strongest antioxidant capacities (1,1-diphenyl-2-picrylhydrazyl, 2,2′-azinobis­(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt and oxygen radical absorbance capacity) as compared to the other tested mung beans. Jiheilv 27-3 exhibited higher antidiabetic activities (inhibition of α-glucosidase and advanced glycation end products)

Main characteristics of the included studies.

<p>IL: intratumoral lymphocytes; PL: peritunoral lymphocytes; TC: tumor cells; UK: United Kingdom; estrogen receptor; NP: not provided; UA: univariate analysis; MA: multivariate analysis; O: observational study; E: experimental study; OS: overallsurvival; DFS: disease-free survival; CP: clinicopathological parameters.</p><p>Main characteristics of the included studies.</p

Sensitivity analysis of OS in the meta-analysis.

<p>Sensitivity analysis of OS in the meta-analysis.</p