Advances in the research of warship structural damage due to inner explosion

Anti-ship missile is the main threat to warship survivability. Having scientific understanding to the complex damage elements and its damage process when missile explosion occurred inner cabin is the important premise to warship protection structure design. But so far the researches on quantitative description of damage elements including explosion shock wave, fragments and explosive products, and damage mechanism and quantitative characterization of warship hull under those damage loading is far from adequate. On the basis of reviewing the achievements on the field that warship hull subjected to missile warhead inner explosion in recent years, the loading characteristic of damage elements were analyzed, and then specially focused on the main damage processes, research achievements in theory, simulation and experimentation were summarized. Some adequate in basic research was present in the end and some suggestion was put forward, which can provided useful reference to the design and related research on warship protection structures

Revealing the roles of TLR7, a nucleic acid sensor for COVID-19 in pan-cancer

Recent studies suggested that cancer was a risk factor for coronavirus disease 2019 (COVID-19). Toll-like receptor 7 (TLR7), a severe acute respiratory syndrome 2 (SARS-CoV-2) virus's nucleic acid sensor, was discovered to be aberrantly expressed in many types of cancers. However, its expression pattern across cancers and association with COVID-19 has not been systematically studied. In this study, we proposed a computational framework to comprehensively study the roles of TLR7 in COVID-19 and pan-cancers at genetic, gene expression, protein, epigenetic, and single-cell levels. We found TLR7 mRNA expression was significantly up-regulated in 6 cancer types and down-regulated in 6 cancer types, further validated in the HPA database at the protein level. The genes significantly co-expressed with TLR7 were mainly enriched in the toll-like receptor signaling pathway, endolysosome, and signaling pattern recognition receptor activity. In addition, the abnormal TLR7 expression was associated with Mismatch repair (MMR), microsatellite instability (MSI), tumor mutational burden (TMB) in various cancers. Mined by the ESTIMATE algorithm, the expression of TLR7 was also closely linked to various immune infiltration patterns in pan-cancer, and TLR7 was mainly enriched in macrophages, as revealed by single-cell RNA sequencing. Finally, TLR7 expressions were very sensitive to a few targeted drugs, such as Alectinib and Imiquimod. In conclusion, TLR7 might be essential in the pathogenesis of COVID-19 and cancers

Naturalism, nature and questions of style in Jinsha River rock art, Northwest Yunnan, China

The naturalistic rock art of Yunnan Province is poorly known outside of China despite two decades of investigation by local researchers. The authors report on the first major international study of this art, its place in antiquity and its resemblance to some of the rock art of Europe, southern Africa and elsewhere. While not arguing a direct connection between China, Europe and other widely separated places, this article suggests that rock-art studies about the nature of style, culture contact and the transmission of iconography across space and time need to take better account of the results of neuroscience research, similar economic/ecological circumstances and the probability of independent invention

Experimental Investigation of the Vibration Reduction of the Pipeline System with a Particle Impact Damper under Random Excitation

In the engineering field, severe vibration of the pipeline system occurs under random excitation, which leads to vibration failure of the pipeline system due to overload. The traditional method is to increase the rigidity of the pipeline system, and to avoid low-frequency resonance by using clamps or damping materials. However, due to structural limitations, it is difficult to apply clamps and damping materials. Particle damping technology has been applied in many fields, and the vibrational energy in the broadband frequency domain could be dissipated based on nonlinear particle collision damping. In this paper, a particle impact damper is designed for vibration reduction of the pipeline system. The damping capability is identified to investigate the effects of particle material, filling rate, particle size, damper structure, and boundary conditions. The results indicate that the ideal damping performance can be obtained by properly selecting particle parameters. Based on applying particle damping on the pipeline system, the proposed particle impact damper showed excellent damping capability under random excitation

Naturalism, Nature and Questions of Style in Jinsha River Rock Art, Northwest Yunnan, China

The naturalistic rock art of Yunnan Province is poorly known outside of China despite two decades of investigation by local researchers. The authors report on the first major international study of this art, its place in antiquity and its resemblance to some of the rock art of Europe, southern Africa and elsewhere. While not arguing a direct connection between China, Europe and other widely separated places, this article suggests that rock-art studies about the nature of style, culture contact and the transmission of iconography across space and time need to take better account of the results of neuroscience research, similar economic/ecological circumstances and the probability of independent invention

Uranium-series age estimates for rock art in southwest China

We report the first uranium-series age estimates for rock art in China. Calcite bracketing a paint layer was used to constrain the age of a naturalistic outline hunter-gatherer painting in the Jinsha River area of northwest Yunnan Province (southwest China). The rock paintings in this region are unique in style and content compared with other bodies of rock art in China, which are dominated by Neolithic subject matter. The minimum and maximum ages were determined using isochron techniques on multiple samples of calcite from above and beneath the paint layer. A large painted deer head was dated to between 5738 and 2050 years. This painting and underlying flowstone are superimposed on older paintings that suggest the older paintings are at least 3400 years old, if not older than 5738 years. The results indicate for the first time that Jinsha River rock art is older than other forms of rock art in the region and show that rock art likely extends back to at least the transition from the Palaeolithic to Neolithic in this part of China

Uranium-series age estimates for rock art in southwest China

We report the first uranium-series age estimates for rock art in China. Calcite bracketing a paint layer was used to constrain the age of a naturalistic outline hunter-gatherer painting in the Jinsha River area of northwest Yunnan Province (southwest China). The rock paintings in this region are unique in style and content compared with other bodies of rock art in China, which are dominated by Neolithic subject matter. The minimum and maximum ages were determined using isochron techniques on multiple samples of calcite from above and beneath the paint layer. A large painted deer head was dated to between 5738 and 2050 years. This painting and underlying flowstone are superimposed on older paintings that suggest the older paintings are at least 3400 years old, if not older than 5738 years. The results indicate for the first time that Jinsha River rock art is older than other forms of rock art in the region and show that rock art likely extends back to at least the transition from the Palaeolithic to Neolithic in this part of China

Programmed Cell Death Protein 1 Inhibitor-Mediated Peripheral Neuropathy

The discovery of immune checkpoint inhibitors (ICIs) has revolutionized the model of antitumor therapy. With the continuous deepening of the research on the mechanism of immunotherapy, ICIs, such as programmed cell death protein 1 (PD-1), programmed death-ligand 1 inhibitors and cytotoxic T lymphocyte-associated protein 4 inhibitors, have been widely used in a variety of tumors. Nevertheless, the use of ICI can also lead to a series of immune-related adverse events. Common immune-related adverse events include gastrointestinal toxicity, pulmonary toxicity, endocrine system toxicity, and skin toxicity. Neurologic adverse events are relatively rare, but they seriously affect the quality of life and shorten the survival time of patients. This article reports cases of peripheral neuropathy mediated by PD-1 inhibitors and retrieves the relevant literatures at home and abroad to summarize the neurotoxicity caused by PD-1 inhibitors, so as to strengthen the awareness of clinicians and patients on neurologic adverse reactions and mitigate potential adverse effects of implemented therapies

Changes in soil microbial communities at Jinsha earthen site are associated with earthen site deterioration

Abstract Background Earthen sites are immobile cultural relics and an important part of cultural heritage with historical, artistic and scientific values. The deterioration of features in earthen sites result in permanent loss of cultural information, causing immeasurable damage to the study of history and culture. Most research on the deterioration of earthen sites has concentrated on physicochemical factors, and information on microbial communities in earthen sites and their relationship with the earthen site deterioration is scarce. We used high-throughput sequencing to analyze bacterial and fungal communities in soils from earthen walls with different degree of deterioration at Jinsha earthen site to characterize the microbial communities and their correlation with environmental factors, and to compare microbial community structures and the relative abundances of individual taxa associated with different degree of deterioration for identifying possible marker taxa. Results The relative abundances of Proteobacteria and Firmicutes were higher and that of Actinobacteria lower with higher degree of deterioration. At the genus level, the relative abundances of Rubrobacter were highest in all sample groups except in the most deteriorated samples where that of Bacteroides was highest. The relative abundance of the yeast genus Candida was highest in the severely deteriorated sample group. The bacterial phylum Bacteroidetes and genus Bacteroides, and fungal class Saccharomycetes that includes Candida sp. were specific for the most deteriorated samples. For both bacteria and fungi, the differences in community composition were associated with differences in EC, moisture, pH, and the concentrations of NH4+, K+, Mg2+, Ca2+ and SO42−. Conclusion The microbial communities in soil with different degree of deterioration were distinctly different, and deterioration was accompanied with bigger changes in the bacterial than in the fungal community. In addition, the deteriorated soil contained higher concentrations of soluble salts. Potentially, the accumulation of Bacteroides and Candida plays an important role in the deterioration of earthen features. Further work is needed to conclude whether controlling the growth of the bacteria and fungi with high relative abundances in the deteriorated samples can be applied to alleviate deterioration