Revisiting Charmless Hadronic B_{u,d} Decays in QCD Factorization

Within the framework of QCD factorization (QCDF), we consider two different types of power correction effects in order to resolve the CP puzzles and rate deficit problems with penguin-dominated two-body decays of B mesons and color-suppressed tree-dominated $\pi^0\pi^0$ and $\rho^0\pi^0$ modes: penguin annihilation and soft corrections to the color-suppressed tree amplitude. We emphasize that the electroweak penguin solution to the $B\to K\pi$ CP puzzle via New Physics is irrelevant for solving the CP and rate puzzles related to tree-dominated decays. While some channels e.g. $K^-\pi^+,K^-\rho^0,\pi^+\pi^-,\rho^\pm\pi^\mp$ need penguin annihilation to induce the correct magnitudes and signs for their CP violation, some other decays such as $B^-\to K^-\pi^0,\pi^-\eta, K^-\eta$ and $\bar B^0\to \bar K^{*0}\eta,\pi^0\pi^0$ require the presence of both power corrections to account for the measured CP asymmetries. In general, QCDF predictions for the branching fractions and direct CP asymmetries of $\bar B\to PP,VP,VV$ decays are in good agreement with experiment. The predictions of pQCD and soft-collinear effective theory are included for comparison.Comment: 51 pages, 1 figur

Combating antimicrobial resistance in Singapore: a qualitative study exploring the policy context, challenges, facilitators, and proposed strategies

Antimicrobial resistance (AMR) is a global public health threat that warrants urgent attention. However, the multifaceted nature of AMR often complicates the development and implementation of comprehensive policies. In this study, we describe the policy context and explore experts' perspectives on the challenges, facilitators, and strategies for combating AMR in Singapore. We conducted semi-structured interviews with 21 participants. Interviews were transcribed verbatim and were analyzed thematically, adopting an interpretative approach. Participants reported that the Ministry of Health (MOH) has effectively funded AMR control programs and research in all public hospitals. In addition, a preexisting One Health platform, among MOH, Agri-Food & Veterinary Authority (restructured to form the Singapore Food Agency and the Animal & Veterinary Service under NParks in April 2019), National Environment Agency, and Singapore's National Water Agency, was perceived to have facilitated the coordination and formulation of Singapore's AMR strategies. Nonetheless, participants highlighted that the success of AMR strategies is compounded by various challenges such as surveillance in private clinics, resource constraints at community-level health facilities, sub-optimal public awareness, patchy regulation on antimicrobial use in animals, and environmental contamination. This study shows that the process of planning and executing AMR policies is complicated even in a well-resourced country such as Singapore. It has also highlighted the increasing need to address the social, political, cultural, and behavioral aspects influencing AMR. Ultimately, it will be difficult to design policy interventions that cater for the needs of individuals, families, and the community, unless we understand how all these aspects interact and shape the AMR response.This research is funded through the CoSTAR-HS and SPHERiC Collaborative Center Grants from the National Medical Research Council, Singapore

Nonleptonic charmless two-body B→ATB \to AT decays

In this work we have studied hadronic charmless two-body B decays involving p-wave mesons in final state. We have calculated branching ratios of $B\to AT$ decays (where $A$ and $T$ denotes a $^3P_1$ axial-vector and a tensor meson, respectively), using $B \to T$ form factors obtained in the covariant light-front (CLF) approach, and the full effective Hamiltonian. We have obtained that $\mathcal{B}(B^{0} \to a_{1}^{+}a_{2}^{-}) =42.47 \times10^{-6}$, $\mathcal{B}(B^{+} \to a_{1}^{+}a_{2}^{0}) = 22.71 \times10^{-6}$, $\mathcal{B}(B \to f_{1}K_{2}^{*}) = (2.8-4) \times 10^{-6}$ (with $f_{1}=, f_{1}(1285),f_{1}(1420)$) for $\theta_{^{3}P_{1}} = 53.2^{\circ}$, $\mathcal{B}(B \to f_{1}(1420)K_{2}^{*}) = (5.91-6.42) \times 10^{-6}$ with $\theta_{^{3}P_{1}} = 27.9^{\circ}$, $\mathcal{B}(B \to K_{1}a_{2})= (1.7 - 5.7) [1-9.3] \times10^{-6}$ for $\theta_{K_{1}} = -37^{\circ} [-58^{\circ}]$ where $K_1 = K_1(1270), K_1(1400)$. It seems that these decays can be measured in experiments at $B$ factories. Additionally, we have found that $\mathcal{B}(B \to K_{1}(1270)a_{2})/\mathcal{B}(B \to K_{1}(1400)a_{2})$ and $\mathcal{B}(B \to f_1(1420)K_{2}^{*})/\mathcal{B}(B \to f_1(1285)K_{2}^{*})$ ratios could be useful to determine numerical values of mixing angles $\theta_{K_{1}}$ and $\theta_{^{3}P_{1}}$, respectively.Comment: 12 page

Implications of Recent Bˉ0→D(∗)0X0\bar{B}^0\to D^{(*)0}X^0 Measurements

The recent measurements of the color-suppressed modes $\bar B^0\to D^{(*)0}\pi^0$ imply non-vanishing relative final-state interaction (FSI) phases among various $\bar B\to D\pi$ decay amplitudes. Depending on whether or not FSIs are implemented in the topological quark-diagram amplitudes, two solutions for the parameters $a_1$ and $a_2$ are extracted from data using various form-factor models. It is found that $a_2$ is not universal: $|a_2(D\pi)|= 0.40-0.55$ and $|a_2(D^*\pi)|= 0.25-0.35$ with a relative phase of order $(50-55)^\circ$ between $a_1$ and $a_2$. If FSIs are not included in quark-diagram amplitudes from the outset, $a_2^{eff}/a_1^{eff}$ and $a_2^{eff}$ will become smaller. The large value of $|a_2(D\pi)|$ compared to $|a_2^{eff}(D\pi)|$ or naive expectation implies the importance of long-distance FSI contributions to color-suppressed internal $W$-emission via final-state rescatterings of the color-allowed tree amplitude.Comment: 17 pages. The Introduction is substantially revised and the order of the presentation in Sec. 2 is rearranged. To appear in Phys. Re

Bˉ0→π+X\bar B^0 \to \pi^+ X in the Standard Model

In this paper we investigate the possibility of studying $B\to \pi$ form factor using the semi-inclusive decays $\bar B^0 \to \pi^+ + X_q$. In general $B\to PX$ semi-inclusive decays involve several hadronic parameters. But for $\bar B^0 \to \pi^+ X_q$ decays we find that in the factorization approximation, the only unknown hadronic parameters are the form factors $F^{B\to \pi}_{0,1}$. Therefore these form factors can be studied in $\bar B^0 \to \pi^+ X_q$ decays. Using theoretical model calculations for the form factors the branching ratios for $\bar B^0 \to \pi^+ X_d(\Delta S = 0)$ and $\bar B^0 \to \pi^+ X_s (\Delta S = -1)$, with the cut $E_{\pi} > 2.1$ GeV, are estimated to be in the ranges of $(3.1\sim 4.9) \times 10^{-5}(F^{B\to \pi}_1(0)/0.33)^2$ and $(2.5\sim 4.2)\times 10^{-5}(F_1^{B\to \pi}(0)/0.33)^2$, respectively, depending on the value of $\gamma$. The combined branching ratio for $\bar B^0 \to \pi^+ (X_d+ X_s)$ is about $7.4\times 10^{-5} (F^{B\to \pi}_1(0)/0.33)^2$ and is insensitive to $\gamma$. We also discuss CP asymmetries in these decay modes.Comment: RevTex 8 pages and two figure

A Cell-Based Small Molecule Screening Method for Identifying Inhibitors of Epithelial-Mesenchymal Transition in Carcinoma

Epithelial Mesenchymal Transition (EMT) is a crucial mechanism for carcinoma progression, as it provides routes for in situ carcinoma cells to dissociate and become motile, leading to localized invasion and metastatic spread. Targeting EMT therefore represents an important therapeutic strategy for cancer treatment. The discovery of oncogene addiction in sustaining tumor growth has led to the rapid development of targeted therapeutics. Whilst initially optimized as anti-proliferative agents, it is likely that some of these compounds may inhibit EMT initiation or sustenance, since EMT is also modulated by similar signaling pathways that these compounds were designed to target. We have developed a novel screening assay that can lead to the identification of compounds that can inhibit EMT initiated by growth factor signaling. This assay is designed as a high-content screening assay where both cell growth and cell migration can be analyzed simultaneously via time-course imaging in multi-well plates. Using this assay, we have validated several compounds as viable EMT inhibitors. In particular, we have identified compounds targeting ALK5, MEK, and SRC as potent inhibitors that can interfere with EGF, HGF, and IGF-1 induced EMT signaling. Overall, this EMT screening method provides a foundation for improving the therapeutic value of recently developed compounds in advanced stage carcinoma

Covariant Light-Front Approach for s-wave and p-wave Mesons: Its Application to Decay Constants and Form Factors

We study the decay constants and form factors of the ground-state s-wave and low-lying p-wave mesons within a covariant light-front approach. Numerical results of the form factors for transitions between a heavy pseudoscalar meson and an s-wave or p-wave meson and their momentum dependence are presented in detail. In particular, form factors for heavy-to-light and B to D** transitions, where D** denotes generically a p-wave charmed meson, are compared with other model calculations. The experimental measurements of the decays B^- to D** pi^- and B to D D**_s are employed to test the decay constants of D**_s and the B to D** transition form factors. The heavy quark limit behavior of the decay constants and form factors is examined and it is found that the requirement of heavy quark symmetry is satisfied. The universal Isgur-Wise (IW) functions, one for s-wave to s-wave and two for s-wave to p-wave transitions, are obtained. The values of IW functions at zero recoil and their slope parameters can be used to test the Bjorken and Uraltsev sum rules.Comment: 59 pages, 6 figures. Version to appear in Phys. Rev. D. Changes are: (i) D_s to phi transition form factors are discussed and compared with the recent FOCUS measurements and (ii) zero mode effects are clarifie

Light-Front Approach for Heavy Pentaquark Transitions

Assuming the two diquark structure for the pentaquark state as advocated in the Jaffe-Wilczek model, there exist exotic parity-even anti-sextet and parity-odd triplet heavy pentaquark baryons. The theoretical estimate of charmed and bottom pentaquark masses is quite controversial and it is not clear whether the ground-state heavy pentaquark lies above or below the strong-decay threshold. We study the weak transitions of heavy pentaquark states using the light-front quark model. In the heavy quark limit, heavy-to-heavy pentaquark transition form factors can be expressed in terms of three Isgur-Wise functions: two of them are found to be normalized to unity at zero recoil, while the third one is equal to 1/2 at the maximum momentum transfer, in accordance with the prediction of the large-Nc approach or the quark model. Therefore, the light-front model calculations are consistent with the requirement of heavy quark symmetry. Numerical results for form factors and Isgur-Wise functions are presented. Decay rates of the weak decays Theta_b+ to Theta_c0 pi+ (rho+), Theta_c0 to Theta+ pi- (rho-), Sigma'_{5b}+ to Sigma'_{5c}0 pi+ (rho+) and Sigma'_{5c}0 to N_8+ pi- (rho-) with Theta_Q, Sigma'_{5Q} and N_8 being the heavy anti-sextet, heavy triplet and light octet pentaquarks, respectively, are obtained. For weakly decaying Theta_b+ and Theta_c0, the branching ratios of Theta_b+ to Theta_c0 pi+, Theta_c0 to Theta+ pi- are estimated to be at the level of 10^{-3} and a few percents, respectively.Comment: 33 pages, 3 figures, version to be published in Phys. Rev.