32 research outputs found
Research And Implementation Of Drug Target Interaction Confidence Measurement Method Based On Causal Intervention
The identification and discovery of drug-target Interaction (DTI) is an
important step in the field of Drug research and development, which can help
scientists discover new drugs and accelerate the development process.
KnowledgeGraph and the related knowledge graph Embedding (KGE) model develop
rapidly and show good performance in the field of drug discovery in recent
years. In the task of drug target identification, the lack of authenticity and
accuracy of the model will lead to the increase of misjudgment rate and the low
efficiency of drug development. To solve the above problems, this study focused
on the problem of drug target link prediction with knowledge mapping as the
core technology, and adopted the confidence measurement method based on causal
intervention to measure the triplet score, so as to improve the accuracy of
drug target interaction prediction model. By comparing with the traditional
Softmax and Sigmod confidence measurement methods on different KGE models, the
results show that the confidence measurement method based on causal
intervention can effectively improve the accuracy of DTI link prediction,
especially for high-precision models. The predicted results are more conducive
to guiding the design and development of followup experiments of drug
development, so as to improve the efficiency of drug development.Comment: 8 pages,11 figure
Riemannian Natural Gradient Methods
This paper studies large-scale optimization problems on Riemannian manifolds
whose objective function is a finite sum of negative log-probability losses.
Such problems arise in various machine learning and signal processing
applications. By introducing the notion of Fisher information matrix in the
manifold setting, we propose a novel Riemannian natural gradient method, which
can be viewed as a natural extension of the natural gradient method from the
Euclidean setting to the manifold setting. We establish the almost-sure global
convergence of our proposed method under standard assumptions. Moreover, we
show that if the loss function satisfies certain convexity and smoothness
conditions and the input-output map satisfies a Riemannian Jacobian stability
condition, then our proposed method enjoys a local linear -- or, under the
Lipschitz continuity of the Riemannian Jacobian of the input-output map, even
quadratic -- rate of convergence. We then prove that the Riemannian Jacobian
stability condition will be satisfied by a two-layer fully connected neural
network with batch normalization with high probability, provided that the width
of the network is sufficiently large. This demonstrates the practical relevance
of our convergence rate result. Numerical experiments on applications arising
from machine learning demonstrate the advantages of the proposed method over
state-of-the-art ones
Crystal structure, thermal analyses, and acetate binding properties in Zinc(II) complex of a urea-functionalized pyridyl ligand
1302-1310A zinc(II) acetate complex with a urea-functionalized pyridyl ligand, [ZnL2(OAc)2]路2H2O (1) (L = N-(4-chlorophenyl)-N'-(4-pyridyl)urea), has been synthesized by the reaction of L with Zn(OAc)2路2H2O under water-containing condition. X-ray single-crystal diffraction analyses reveal that 2-D sheetlike network structure has been formed by the urea N鈭扝脳脳脳Npyridyl interactions and C鈥揌路路路O interactions in the free ligand L. Complex 1 features 3-D hydrogen bonded network formed by intermolecular N鈭扝路路路O hydrogen bonds and O鈭扝脳脳脳O hydrogen bonds involving urea groups, acetate anions and bridged water molecules. The hydrogen bonds play an important role in stabilizing the supramolecular structures. Thermal gravity analyses have been used to investigate the thermal stabilities of L and 1, and the apparent activation energy (Ea) of the decompositions have also been calculated, and the results indicate that the main decomposition of L needs higher apparent activation energy values Ea than that of 1. The acetate binding properties of L in solution have also been evaluated by Ultraviolet-Visible (UV-Vis) spectroscopy. CCDC: 1506202, L; 1506203, 1