Phenomenological discriminations of the Yukawa interactions in two-Higgs doublet models with Z2Z_2 symmetry

There are four types of two-Higgs doublet models under a discrete $Z_2$ symmetry imposed to avoid tree-level flavour-changing neutral current, i.e. type-I, type-II, type-X and type-Y models. We investigate the possibility to discriminate the four models in the light of the flavour physics data, including $B_s-\bar B_s$ mixing, $B_{s,d} \to \mu^+ \mu^-$, $B\to \tau\nu$ and $\bar B \to X_s \gamma$ decays, the recent LHC Higgs data, the direct search for charged Higgs at LEP, and the constraints from perturbative unitarity and vacuum stability. After deriving the combined constraints on the Yukawa interaction parameters, we have shown that the correlation between the mass eigenstate rate asymmetry $A_{\Delta\Gamma}$ of $B_{s} \to \mu^+ \mu^-$ and the ratio $R={\cal B}(B_{s} \to \mu^+ \mu^-)_{exp}/ {\cal B}(B_{s} \to \mu^+ \mu^-)_{SM}$ could be sensitive probe to discriminate the four models with future precise measurements of the observables in the $B_{s} \to \mu^+ \mu^-$ decay at LHCb.Comment: 29 pages, 4 tables, 11 figures. v3: minor corrections included, matches published version in EPJ

Effect of MiR-423-5p expression on the severity of lipopolysaccharide-induced acute liver injury, inflammatory response and immune function in mice

Purpose: To investigate the biological functions of miR-423-5p in a mouse model with lipopolysaccharide (LPS)-induced acute liver injury.Methods: Sixty male C57BL/6 mice were randomized into control group (n = 20), LPS group (n = 20) and LPS + miR-423-5p mimic group (n = 20). The levels of pro-inflammatory cytokines and apoptosisassociated proteins in the liver tissues were determined. Finally, the survival of mice was recorded within 7 days after the injection of LPS.Results: Overexpression of miR-423-5p improved the liver function of septic mice, and decreased the content of ALT, AST and LDH. Furthermore, overexpression of miR-423-5p also lowered the levels of the oxidative stress markers 4-HNE and MDA, and raised the content of anti-oxidative enzymes SOD and GSH-Px in the liver tissues of septic mice (p < 0.05). The levels of inflammation and apoptosis in the liver of mice in LPS + miR-423-4p mimic group were lower than those in the LPS group (p < 0.05). The overexpression of miR-432-5p increased CD4+ and CD8+ T cells in the spleen of septic mice (p < 0.05), thereby reducing immunosuppression.Conclusion: The expression of miR-423-5p is low in septic mice with liver injury, but its overexpression alleviates acute liver injury and inflammatory responses, and also enhances immune function in mice. Therefore, it has the potential to serve as a targeted drug for the management of liver injury