Value Orientation of Introducing Social Capital in Medical and Health Services

Introduction of social capital into medical and health services can effectively alleviate the problems of insufficient resources, poor allocation and unbalanced structure in developing medical institutions. Social capital entering medical institutions, through reasonable guidance, differentiated development and fair competition, can effectively promote optimal allocation of medical resources, improve balanced development of medical structures, continuously expand the scale and scope of medical service targets, and improve standard and effectiveness of medical services. The nature of capital is to chase profits. Therefore, after introducing social capital, medical institutions should combine and strengthen self-discipline and heteronomy supervisions, guide this part of capital to actively assume social responsibilities, to fulfill social obligations, and to serve the public, in order to ensure the medical industry to have sustainable growth

Analysis of Development Status of Primary Medical and Health Institutions in Chongqing, China from 2015-2018

The important manifestation of social civilization proves to meet the demands of patients for medical treatment to the greatest extent through promoting grass-roots medical reform, improving construction of grass-roots medical and health institutions and improving their service capabilities. Chongqing, the youngest municipality in China, has a population of 34.04 million, is also a typical city with a prominent urban-rural dual structure. Construction and development of service system in primary-level medical and health institutions is of great significance for improving health of people in Chongqing. This essay uses observation variables such as “community health service center”, “township health institution” and “village clinic” as it’s basis and puts its research objects on Chongqing Statistical Yearbook 2015-2018, the latest data from the National Bureau of Statistics and from Chongqing Municipal Health Commission Statistics Bulletin 2015-2018. Through statistical methods, collected and sorted data are imported into EXCEL table, and corresponding database is established. While statistical indicators include composition ratio, utilization rate, average and etc. and a descriptive statistical analysis is performed. Research and study are given on changes of observation variables of primary medical institutions in Chongqing from 2015 to 2018. It is found that: the number of primary medical institutions showed a downward trend as a whole; the proportion of patients seeking medical treatment through primary diagnosis and treatment was still relatively high; composition of observation variable in township and village level is unreasonable; and slow growth happens in the number of township first-level medical and health institutions and the number of beds. In view of problems found in the research, the essay puts forward some solutions to improve construction of service system of primary health institutions in Chongqing, namely, to invest more in basic construction of primary medical and health institutions, to guide medical graduates to work in primary medical institutions and to increase training and guidance of primary medical technicians. In this way, we can better promote the development of primary-level medical and health institutions in Chongqing and provide citizens with more and better medical services

Expression and Distribution of the Guanine Nucleotide-binding Protein Subunit Alpha-s in Mice Skin Tissues and Its Association with White and Black Coat Colors

Guanine nucleotide-binding protein subunit alpha-s (Gnαs) is a small subunit of the G protein-couple signaling pathway, which is involved in the formation of coat color. The expression level and distribution of Gnαs were detected by quantitative real-time-polymerase chain reaction (qPCR), western blot, and immunohistochemistry to investigate the underlying mechanisms of coat color in white and black skin tissues of mice. qPCR and western blot results suggested that Gnαs was expressed at significantly higher levels in black mice compared with that of white mice, and transcripts and protein possessed the same expression in both colors. Immunohistochemistry demonstrated Gnαs staining in the root sheath and dermal papilla in hair follicle of mice skins. The results indicated that the Gnαs gene was expressed in both white and black skin tissues, and the expression level of Gnαs in the two types of color was different. Therefore, Gnαs may be involved in the coat color formation in mice

Methods and Applications of Full-Scale Field Testing for Large-Scale Circulating Fluidized Bed Boilers

Circulating fluidized bed (CFB) boilers offer a technically viable and environmentally friendly means for the clean and efficient utilization of solid fuels. However, the complex gas–solid two-phase flow processes within them have hindered a thorough resolution of prediction issues related to coupled combustion, heat transfer, and pollutant generation characteristics. To address the deficiencies in scientific research, meet the practical operational needs of CFB boilers, and comply with new carbon emission policies, conducting full-scale field tests on large-scale CFB boilers is needed, so that the complex gas–solid flow, combustion, and heat transfer mechanisms in the furnace can be comprehended. In this paper, issues related to large-scale CFB boilers, including the uniformity of air distribution, secondary air injection range, spatial distribution of oxygen consumption and combustion reactions, distribution of pollutant generation, hydrodynamic and heat transfer characteristics, coal feeding distribution characteristics, coal diffusion characteristics under thermal operating conditions, and engineering research on anti-wear technology, are reviewed. By integrating practical engineering applications, the basic methods and measurement techniques used in full-scale field tests for large-scale CFB boilers are summarized, providing a practical reference for conducting engineering tests with large-scale CFB boilers

Interferon-β Produces Synergistic Combinatory Anti-Tumor Effects with Cisplatin or Pemetrexed on Mesothelioma Cells

<div><p>Interferons (IFNs) have been tested for the therapeutic effects in various types of malignancy, but mechanisms of the anti-tumors effects and the differential biological activities among IFN members are dependent on respective cell types. In this study, we examined growth inhibitory activities of type I and III IFNs on 5 kinds of human mesothelioma cells bearing wild-type <i>p53</i> gene, and showed that type I IFNs but not type III IFNs decreased the cell viabilities. Moreover, growth inhibitory activities and up-regulated expression levels of the major histocompatibility complexes class I antigens were greater with IFN-β than with IFN-α treatments. Cell cycle analyses demonstrated that type I IFNs increased S- and G2/M-phase populations, and subsequently sub-G1-phase fractions. The cell cycle changes were also greater with IFN-β than IFN-α treatments, and these data collectively showed that IFN-β had stronger biological activities than IFN-α in mesothelioma. Type I IFNs-treated cells increased p53 expression and the phosphorylation levels, and activated apoptotic pathways. A combinatory use of IFN-β and cisplatin or pemetrexed, both of which are the current first-line chemotherapeutic agents for mesothelioma, produced synergistic anti-tumor effects, which were also evidenced by increased sub-G1-phase fractions. These data demonstrated firstly to our knowledge that IFN-β produced synergistic anti-tumor effects with cisplatin or pemetrexed on mesothelioma through up-regulated p53 expression.</p> </div