SDPNAL++: A Majorized Semismooth Newton-CG Augmented Lagrangian Method for Semidefinite Programming with Nonnegative Constraints

In this paper, we present a majorized semismooth Newton-CG augmented Lagrangian method, called SDPNAL$+$, for semidefinite programming (SDP) with partial or full nonnegative constraints on the matrix variable. SDPNAL$+$ is a much enhanced version of SDPNAL introduced by Zhao, Sun and Toh [SIAM Journal on Optimization, 20 (2010), pp.~1737--1765] for solving generic SDPs. SDPNAL works very efficiently for nondegenerate SDPs but may encounter numerical difficulty for degenerate ones. Here we tackle this numerical difficulty by employing a majorized semismooth Newton-CG augmented Lagrangian method coupled with a convergent 3-block alternating direction method of multipliers introduced recently by Sun, Toh and Yang [arXiv preprint arXiv:1404.5378, (2014)]. Numerical results for various large scale SDPs with or without nonnegative constraints show that the proposed method is not only fast but also robust in obtaining accurate solutions. It outperforms, by a significant margin, two other competitive publicly available first order methods based codes: (1) an alternating direction method of multipliers based solver called SDPAD by Wen, Goldfarb and Yin [Mathematical Programming Computation, 2 (2010), pp.~203--230] and (2) a two-easy-block-decomposition hybrid proximal extragradient method called 2EBD-HPE by Monteiro, Ortiz and Svaiter [Mathematical Programming Computation, (2013), pp.~1--48]. In contrast to these two codes, we are able to solve all the 95 difficult SDP problems arising from the relaxations of quadratic assignment problems tested in SDPNAL to an accuracy of $10^{-6}$ efficiently, while SDPAD and 2EBD-HPE successfully solve 30 and 16 problems, respectively.Comment: 43 pages, 1 figure, 5 table

Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China

Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for the mortality of patients with SLE-related AP in a cohort of South China. Methods. Inpatient medical records of SLE-related AP were retrospectively reviewed. Results. 27 out of 4053 SLE patients were diagnosed as SLE-related AP, with an overall prevalence of 0.67%, annual incidence of 0.56‰ and mortality of 37.04%. SLE patients with AP presented with higher SLEDAI score (21.70 ± 10.32 versus 16.17 ± 7.51, P = 0.03), more organ systems involvement (5.70 ± 1.56 versus 3.96 ± 1.15, P = 0.001), and higher mortality (37.04% versus 0, P = 0.001), compared to patients without AP. Severe AP (SAP) patients had a significant higher mortality rate compared to mild AP (MAP) (75% versus 21.05%, P = 0.014). 16 SLE-related AP patients received intensive GC treatment, 75% of them exhibited favorable prognosis. Conclusion. SLE-related AP is rare but concomitant with high mortality in South Chinese people, especially in those SAP patients. Activity of SLE, multiple-organ systems involvement may attribute to the severity and mortality of AP. Appropriate glucocorticosteroid (GC) treatment leads to better prognosis in majority of SLE patients with AP

EFFICIENT ALGORITHMS FOR LEAST SQUARES SEMIDEFINITE PROGRAMMING AND SEMIDEFINITE PROGRAMMING WITH A LARGE NUMBER OF CONSTRAINTS

Ph.DDOCTOR OF PHILOSOPH

Research on rural credit union financial risk management and precaution. Case study: Mianzhu rural credit union

The aim of this thesis was to analyse the rural financial institution’s management and prevention as well as the control of financial risks through the specified case study. Post-disaster reconstruction loans have twofold characteristics, not only a positive social meaning, but also financial risks. How does Mianzhu rural credit union issue loans to earthquake victims to support post-disaster reconstruction, and through what methods it manages and guards against the financial risks at the same time? This is the study of this thesis. The study combines qualitative research methods. In the analysis of financial risks management and control using the qualitative research methods mainly, for instance, interview rural credit union departments and prospective borrowers. The results of study include the summary and suggestions of post-disaster reconstruction loans risks management and control in Mianzhu rural credit union, moreover, revelation from the financial support of post-disaster reconstruction and stable operation of regional financial economies

Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus.

This study aims to investigate the fetal outcomes and associated factors of adverse pregnancy outcomes (APOs) in pregnant women with systemic lupus erythematosus (SLE). Clinical data from 251 SLE patients with 263 pregnancies from 2001 to 2015 were analyzed retrospectively. APOs occurred in 70.0% of pregnancies, in which pregnancy loss occurred in 28.5%; preterm delivery occurred in 21.3%; intrauterine growth retardation occurred in 12.2%; and fetal distress occurred in 8.0%. Over time, the rate of APOs decreased from 82.8% during 2001~2005 to 59.6% during 2011~2015. In multivariate analysis, predictors of APOs included positive antiphospholipid antibodies (OR 8.4, 95% CI 1.7~40.8, P = 0.008), lower complement (OR 3.6, 95% CI 1.3~9.9, P = 0.01), hypoalbuminemia (OR 3.2, 95% CI 1.2~8.3, P = 0.02), and hypertension (OR 14.6, 95% CI 1.5~141.6, P = 0.02). The use of antimalarial medications was associated with lower risk for APOs (OR 0.3, 95% CI 0.1~0.7, P = 0.01). In total, 109 patients underwent fetal umbilical artery Doppler in the third trimester. The The adjusted systole/diastole (S/D) ratio, pulsatility index (PI) and resistance index (RI) of SLE patients with APOs were higher than that of patients without APOs (2.9±0.9 vs. 2.4±0.5, P = 0.001). Lupus pregnancy was still at high risk of APOs in terms of pregnancy loss and preterm delivery. Umbilical artery Doppler was a good monitor method for APOs in the third trimester

Chinese Employees’ Psychological Responses to Abusive Supervisors The Roles of Gender and Self-Esteem

Drawing on the conservation of resources theory, the relations between abusive supervision and emotional exhaustion and intent to leave were examined, as well as the gender differences in these relations. Moreover, the moderating effect of self-esteem was tested in an integrated model stipulating that the gender-moderating effect was mediated by the abusive supervision × self-esteem interaction. Data were collected from 264 employees (111 men; M age = 32.0 years; M tenure = 9.2 years). Results of regression analyses indicated that abusive supervision was positively correlated to emotional exhaustion and intent to leave. Women reported higher emotional exhaustion and intent to leave than men. The relations of interest were stronger among employees with higher self-esteem (emotional exhaustion: β = 0.44; intent to leave: β = 0.53). The interaction of abusive supervision × self-esteem mediated the gender-moderating effect. Women\u27s stronger responses to abusive supervision may be related to their higher self-esteem, possibly because of the importance of employment to Chinese women

Associations of the APOB rs693 and rs17240441 polymorphisms with plasma APOB and lipid levels: a meta-analysis

Abstract Background The associations of the apolipoprotein B gene (APOB) rs693 and rs17240441 polymorphisms with plasma levels of APOB and lipids have been widely explored, but the results were inconclusive. This meta-analysis aimed to clarify the associations of the rs693 and rs17240441 polymorphisms with fasting APOB and lipid levels. Methods Sixty-one studies (50,018 subjects) and 23 studies (8425 subjects) were respectively identified for the rs693 and rs17240441 polymorphisms by searching in PubMed, Google Scholar, Web of Science, Cochrane Library, Wanfang, VIP and CNKI databases. The following information was collected for each study: first author, age, gender, ethnicity, health condition, sample size, genotyping, lipid assay method, mean and standard deviation or standard error of APOB and lipid variables by genotypes. A dominant model was used for this meta-analysis. Results The carriers of the rs693 variant allele (T) had higher levels of APOB [standardized mean difference (SMD) = 0.26, 95% confidence interval (CI) = 0.16–0.36, P < 0.01], triglycerides (TG) (SMD = 0.12, 95% CI = 0.05–0.20, P < 0.01), total cholesterol (TC) (SMD = 0.24, 95% CI = 0.17–0.30, P < 0.01) and low-density lipoprotein cholesterol (LDL-C) (SMD = 0.22, 95% CI = 0.14–0.30, P < 0.01), and lower levels of high-density lipoprotein cholesterol (HDL-C) (SMD = −0.06, 95% CI = −0.11–0.01, P = 0.01) than the non-carriers. The carriers of the rs17240441 deletion allele had higher levels of APOB (SMD = 0.13, 95% CI = 0.06–0.20, P < 0.01), TC (SMD = 0.17, 95% CI = 0.07–0.26, P < 0.01) and LDL-C (SMD = 0.15, 95% CI = 0.07–0.23, P < 0.01) than the non-carriers. Conclusions The rs693 polymorphism is significantly associated with higher levels of APOB, TG, TC and LDL-C, and lower levels of HDL-C. The rs17240441 polymorphism is significantly associated with higher levels of APOB, TC and LDL-C. Further studies are needed to elucidate the underlying mechanisms

The Dark Side of Helping: Does Returning the Favor from Coworkers Hurt Employee Work Engagement?

This study investigated the potential dark side of helping behavior at work -- operationalized as provision of social support to coworkers. Drawing from the emotional contagion literature and Conservation of Resources (COR) theory, we proposed and tested a moderated mediational model to examine the mechanisms by which social support received from one\u27s coworkers contribute to the support recipient\u27s work engagement. Employing data from a 12-week-long weekly diary among 142 acute care nurses, we did not find support for the proposed negative relationship between providing social support to coworkers and support providers\u27 work engagement, nor for the overall mediational effect of the relationship between received coworker support and work engagement through support provision. However, we found that some work contextual factors (i.e., stable social support climates from coworkers and supervisors) moderated the weekly processes through which nurses\u27 repaying social support received from coworkers predicts their subsequent work engagement. Specifically, providing support to coworkers had stronger beneficial effects on providers\u27 engagement when coworker/supervisor support climates were relatively low; support received from coworkers had stronger indirect beneficial effects on nurses\u27 engagement when coworker/supervisor support climates were relatively low. Our study findings highlight the complexity of the relationship between social support dynamics and work engagement, and that emotional contagion and COR theory may be insufficient, on their own, to explain social support dynamics between coworkers. We also discuss implications of the findings for managerial practices related to support dynamics at work