Alternating Back-Propagation for Generator Network

This paper proposes an alternating back-propagation algorithm for learning the generator network model. The model is a non-linear generalization of factor analysis. In this model, the mapping from the continuous latent factors to the observed signal is parametrized by a convolutional neural network. The alternating back-propagation algorithm iterates the following two steps: (1) Inferential back-propagation, which infers the latent factors by Langevin dynamics or gradient descent. (2) Learning back-propagation, which updates the parameters given the inferred latent factors by gradient descent. The gradient computations in both steps are powered by back-propagation, and they share most of their code in common. We show that the alternating back-propagation algorithm can learn realistic generator models of natural images, video sequences, and sounds. Moreover, it can also be used to learn from incomplete or indirect training data

Learning Generative ConvNets via Multi-grid Modeling and Sampling

This paper proposes a multi-grid method for learning energy-based generative ConvNet models of images. For each grid, we learn an energy-based probabilistic model where the energy function is defined by a bottom-up convolutional neural network (ConvNet or CNN). Learning such a model requires generating synthesized examples from the model. Within each iteration of our learning algorithm, for each observed training image, we generate synthesized images at multiple grids by initializing the finite-step MCMC sampling from a minimal 1 x 1 version of the training image. The synthesized image at each subsequent grid is obtained by a finite-step MCMC initialized from the synthesized image generated at the previous coarser grid. After obtaining the synthesized examples, the parameters of the models at multiple grids are updated separately and simultaneously based on the differences between synthesized and observed examples. We show that this multi-grid method can learn realistic energy-based generative ConvNet models, and it outperforms the original contrastive divergence (CD) and persistent CD.Comment: CVPR 201

Estimating a Treatment Effect with Repeated Measurements Accounting for Varying Effectiveness Duration

To assess treatment efficacy in clinical trials, certain clinical outcomes are repeatedly measured for same subject over time. They can be regarded as function of time. The difference in their mean functions between the treatment arms usually characterises a treatment effect. Due to the potential existence of subject-specific treatment effectiveness lag and saturation times, erosion of treatment effect in the difference may occur during the observation period of time. Instead of using ad hoc parametric or purely nonparametric time-varying coefficients in statistical modeling, we first propose to model the treatment effectiveness durations, which are the varying time intervals between the lag and saturation times. Then some mean response models are used to include such treatment effectiveness durations. Our methodologies are demonstrated by simulations and an application to the dataset of a landmark HIV/AIDS clinical trial of short-course nevirapine against mother-to-child HIV vertical transmission during labour and delivery