Emergent Spin Phenomena in Air-Stable, Atomically Thin Lead

A stable platform to synthesize ultrathin heavy metals, with a strong interfacial Rashba effect, could lead to high efficiency charge-to-spin conversion for next-generation spintronics. Here we report wafer-scale synthesis of air-stable, epitaxially registered monolayer Pb on SiC (0001) via confinement heteroepitaxy (CHet). The highly asymmetric interfacial bonding in this heavy metal system lends to strong Rashba spin-orbit coupling near the Fermi level. Additionally, the system's air stability enables ex-situ spin torque ferromagnetic resonance (ST-FMR) measurements that demonstrate charge-to-spin conversion in CHet-based 2D-Pb/ferromagnet heterostructures and a 1.5x increase in the effective field ratio compared to control samples.Comment: 17 pages, 4 figures. Supporting Information included (20 pages, 9 figures, 1 table

Effects of mulberry twig alkaloids(Sangzhi alkaloids) and metformin on blood glucose fluctuations in combination with premixed insulin-treated patients with type 2 diabetes

IntroductionWe aimed to evaluated the effect of premixed insulin (Ins), premixed insulin combined with metformin (Ins+Met) or mulberry twig alkaloids(Ins+SZ-A) on blood glucose fluctuations in patients with type 2 diabetes (T2DM) using continuous glucose monitors (CGM).MethodsThirty patients with T2DM and poor blood glucose control using drugs were evaluated for eligibility during the screening period. Subsequently, their original hypoglycemic drugs were discontinued during the lead-in period, and after receiving Ins intensive treatment for 2 weeks, they were randomly assigned to receive either Ins, Ins+Met, or Ins+SZ-A treatment for the following 12 weeks. The main efficacy endpoint comprised changes in their CGM indicators changes (mean blood glucose level [MBG], standard deviation of blood glucose [SDBG], mean amplitude of glycemic excursions [MAGE], postprandial glucose excursions [PPGE], the largest amplitude of glycemic excursions [LAGE], mean of daily difference [MODD], time in range between 3.9–10.0 mmol/L [TIR] and area under the curve for each meal [AUCpp]) during the screening, lead-in, and after 12-week treatment period. Changes in glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), 1-h postprandial blood glucose (1h-PBG), 2-h postprandial blood glucose (2h-PBG), fasting blood lipids and postprandial blood lipids were also measured at baseline and after 12 weeks of treatmentResultsThe CGM indicators of the three groups during the lead-in period all showed significant improvements compared to the screening period (P<0.05). Compared with those in the lead-in period, all of the CGM indicators improved in the the Ins+Met and Ins+SZ-A groups after 12 weeks of treatment (P<0.05), except for MODD. After 12-week treatment, compared with the Ins group, Ins+Met and Ins+SZ-A groups showed improved MBG, SDBG, TIR, breakfast AUCpp,lunch AUCpp, HbA1c, FBG, 1h-PBG, fasting blood lipid and postprandial blood lipid indicators (P<0.05). Further, the LAGE, PPGE, MAGE, dinner AUCpp and 2h-PBG levels of the Ins+SZ-A group were significantly lower than those of the Ins+Met and Ins groups (P<0.05).ConclusionOur findings highlight the efficacy of combination therapy (Ins+SZ-A or Ins+Met) in improving blood glucose fluctuations, as well as blood glucose and lipid levels. Ins+SZ-A reduces postprandial blood glucose fluctuations more than Ins+Met and Ins groups.Trial registration numberISRCTN20835488

Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes

Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion of innate immune system genes in the mudskippers that may provide defence against terrestrial pathogens. Several genes of the ammonia excretion pathway in the gills have experienced positive selection, suggesting their important roles in mudskippers’ tolerance to environmental ammonia. Some vision-related genes are differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in response to hypoxia. The present study provides a valuable resource for understanding the molecular mechanisms underlying water-to-land transition of vertebrates

横断山树蛙—新种 —贡山树蛙

Volume: 3Start Page: 51End Page: 5

Random Maintenance Strategy Modeling of Warranted Products with Reliability Heterogeneity

Using monitored job cycles to design and model random maintenance strategies for ensuring life-cycle reliability has been extensively researched. The reliability heterogeneity over the life cycle has been ignored universally in this type of strategy. In this paper, using two different areas of regions that can screen reliability, two random maintenance strategies were customized for the life-cycle reliabilities of warrantied products with monitored job cycles to be ensured based on reliability heterogeneity. In the case of using minimal repair, the first one was flexibly customized depending on whether the first failure occurs in the region consisting of limited job cycles or a period of warranty service, whichever occurs first. Such a strategy is called flexible repair warranty first (FRWF) and can be used to ensure warranty-stage reliability during a product’s life cycle. The FRWF strategy is modeled from the perspectives of cost and time measures. Based on whether the first failure of the product through its FRWF occurs in another region, random periodic replacement (RPR) and classic periodic replacement (CPR) are triggered to customize the second one, which is named bivariate customized random maintenance (BCRM) because two decision variables are considered. The BCRM and its variants are modeled from the perspectives of the average cost rates. Finally, numerical analysis of some of the customized strategies was performed from the numerical perspective. Numerical analysis showed that the presented FRWF is superior to the classic free repair warranty (FRW) strategy because the servicing time of the presented FRWF strategy is longer than the servicing time of the classic FRW strategy at the same cost

Estimation of the Mean Trace Length of Discontinuities in an Underground Drift Using Laser Scanning Point Cloud Data

In the drifts of underground metal mines, the extraction of rock mass discontinuity characteristics from point cloud models generated with laser scanning has become the main approach. However, the exposure of discontinuities is restricted in drifts, and the size of discontinuities cannot be measured directly. Therefore, it is necessary to use a reasonable sampling tool to estimate the mean trace length of the discontinuities that are mapped in the point cloud model. In this paper, a method to estimate the mean trace length of discontinuities using a three-dimensional (3D) model of a drift (3DM) is proposed. Through the point cloud data of a drift obtained using 3D laser scanning, the information on discontinuities in the surrounding rock was extracted; then, the mean trace length was estimated using 3DEC to set sampling windows on the roof and sidewall in the 3DM. By analyzing the difference between the circular sampling window and the rectangular sampling window using simulated cases, the estimation results showed that the mean trace length obtained using circular measuring windows in the 3DM was closer to the true trace length. Finally, the method was used in a practical engineering case in Jianshan Iron Mine, Panzhihua, Sichuan, China

Estimation of the Mean Trace Length of Discontinuities in an Underground Drift Using Laser Scanning Point Cloud Data

In the drifts of underground metal mines, the extraction of rock mass discontinuity characteristics from point cloud models generated with laser scanning has become the main approach. However, the exposure of discontinuities is restricted in drifts, and the size of discontinuities cannot be measured directly. Therefore, it is necessary to use a reasonable sampling tool to estimate the mean trace length of the discontinuities that are mapped in the point cloud model. In this paper, a method to estimate the mean trace length of discontinuities using a three-dimensional (3D) model of a drift (3DM) is proposed. Through the point cloud data of a drift obtained using 3D laser scanning, the information on discontinuities in the surrounding rock was extracted; then, the mean trace length was estimated using 3DEC to set sampling windows on the roof and sidewall in the 3DM. By analyzing the difference between the circular sampling window and the rectangular sampling window using simulated cases, the estimation results showed that the mean trace length obtained using circular measuring windows in the 3DM was closer to the true trace length. Finally, the method was used in a practical engineering case in Jianshan Iron Mine, Panzhihua, Sichuan, China

The Impact of Human Activities on Net Primary Productivity in a Grassland Open-Pit Mine: The Case Study of the Shengli Mining Area in Inner Mongolia, China

In grassland open-pit mining areas, net primary productivity (NPP) is mainly affected by climate conditions and human activities. The identification and assessment of the influence of human activities on NPP is important for mining production and the implementation of ecological restoration. In this study, we explored the influence of human activities on the NPP in the Shengli mining area in Inner Mongolia, China by using the Carnegie–Ames–Stanford Approach (CASA) model and the Chikugo model, in which a calibration method was applied. An analysis of four representative years showed that the proportion of NPP induced by human activities reached 56.2%, that the percentage of pixels with an inhibitory effect on NPP was 99% in 2011 with the highest intensity of mining activity, and that these two values decreased to 11.9% and 69% in 2020, respectively, with the steady implementation of ecological restoration. Moreover, from the analysis of global and local spatial correlation, mining activities and ecological restoration aggravated and weakened the aggregation of NPP induced by human activities, respectively

Geophysical Characterisation and Oil–Gas Resource Analysis of the Southern Huaying Mountain Fault Zone, Sichuan Basin, China

As the west rim of an ejective fold zone, the Huaying Mountain fault zone (HMFZ) in the eastern Sichuan Basin (SB) plays an important role in the tectonic evolution of the SB. The distribution and characteristics of HMFZ are strongly associated with tectonic activities and have greatly impacted the distribution of oil and gas reservoirs. However, its distribution and characteristics have remained poorly understood due to a lack of geophysical data, especially areal gravity survey and magnetotellurics (MT) survey, which are admittedly advantageous for detecting the edges of geological structures. Therefore, we carried out the ground geophysical surveys that areal gravity survey and MT survey, and acquired 1:250,000-scale real gravity data and MT data for the first time in this area. Optimized edge-detection methods were adopted to process the areal gravity data, allowing us to characterize the planar distribution of faults more reliably and convincingly. We found that the southern HMFZ is well developed and primarily trends in NNE and NE, whereas the subordinate faults trend in N-S and W-E. Vertical information for the faults extracted using the improved depth from the extreme points method revealed that the fault dominantly dipped to the SE, which was consistent with the results of MT inversion. Based on the spatial distribution of the faults, we further discussed the gravity anomaly, fault distribution, Luzhou palaeo uplift, and the distribution and characteristics of oil-gas resources, and found the convincing evidence to analysis the distribution of oil and gas resources in this region