A Solution to the Ambiguity Problem in Depth Contouring

Depth contours on a chart are important for safe navigation. The ambiguity problem can appear when points of equal depth are joined in contouring. Unreasonable solutions may mistake a shallow area for a deep one, which could result in a potential danger for navigation. A solution is presented to solve the ambiguity problem using constrained lines formed by two shallow depths. The constrained lines are used to limit the joining of the points with equal depth. Experimental results demonstrate that the proposed solution can reduce the dangers of producing non-existent deep areas in bathymetric contouring.Las isobatas en una carta son importantes para la seguridad de la navegaciôn. El problema de ambiguedad puede aparecer cuando puntos de igual profundidad se unen en el trazado de la isobata. Soluciones no razonadas pueden confundir un area somera por una profunda, lo que podria resultar en un peligro potencial a la navegaciôn. Una soluciôn se présenta para resolver el problema de ambigüedad utilizando lineas forzadas formadas por dos profundidades s orneras. Las lineas forzadas se ut Uizan para limitar la union de puntos con igual profundidad. Los resultados expérimentales demuestran que la soluciôn propuesta puede reducir los peligros de producir areas profundas no existentes en los contornos batimétricos.Sur une carte, les isobathes sont importantes en ce qui concerne la sécurité de la navigation. Le problème de l'ambiguïté peut apparaître lorsque des points de profondeur égale se rejoignent sur le tracé de l'isobathe. Certaines solutions non fondées rationnellement peuvent prendre par erreur une zone peu profonde pour une zone profonde, ce qui peut entraîner un danger potentiel pour la navigation. Une solution est présentée pour résoudre le problème de l’ambiguïté en utilisant des lignes contraintes formées par deux faibles profondeurs. Les lignes contraintes sont utilisées pour limiter la réunion de points d’une égale profondeur. Des résultats expérimentaux ont montré que la solution proposée peut réduire les dangers liés à la création de zones profondes non existantes dans le tracé bathymétrique

Analysis of the Functional Components of Acid Protease and Investigation of Bating Mechanism of Wet-blue

Content: In this study, different acid proteases, which were produced from Aspergillus and Bacillus, were applied for wet-blue bating and their properties and bating effects were observed. The results showed that the acid protease produced Aspergillus had better bating effect and higher chromium tolerance than that of produced by Bacillus. Furthermore, how the acid protease influenced wet-blue microstructure was analyzed by SEM and Micro-CT. The enzymatic properties of acid protease was studied firstly.Zeta potential analysis showed that the isoelectric point (pI) of the protease was consistent with its pH value, which was at 3.0. By particle size analysis, it found that its particle size was 700 nm. In order to obtain the functional components, the molecular weight of the acidic protease was analyzed by Polyacrylamide gel Electrophoresis (SDS-PAGE). Different molecular weight components were obtained by separating the acidic protease with Tangential Flow Filtration (TFF) Technology. The characteristics of these components were determined such as enzyme types and their proportion. Afterwards, these different molecular weight components were used for wet-blue bating. The bating effluent was collected, and then, contents of Hydroxyproline (Hyp), Hyaluronic acid (HA), Desmosine (Des) and Chondroitin sulfate (CS) were analysed, which could be directly corresponding with the degradation of different proteins in wet-blue. Therefore, by characterizing and comparing the bating effect influenced with these different molecular weight components, the functional components of protease could be identified and further be separated and purified. Based on these results, this research is helpful to the development and study of the action of acid protease in the wet-blue bating process. Take-Away: Micro-CT as a new way to characterize the microstructure of leather; Identification and Separation of Effective Components of Acid Protease； Degradation Analysis of Main Components of Wet-Blue during bating process

10-Benzyl-10H-phenothia­zine 9-oxide

In the title compound, C19H15NOS, the butterfly angle between the mean planes defined by the S, N and phenyl C atoms of the two wings of the phenothiazine unit is 23.4 (1)°. In the crystal, a supra­molecular two-dimensional arrangement arises from weak inter­molecular C—H⋯O inter­actions

2-[7-Chloro-1,1-dioxo-2-(2,4,5-trifluoro­benz­yl)-3,4-dihydro-2H-1,2,4-benzothia­diazin-4-yl]acetic acid

In the mol­ecule of the title compound, C16H12ClF3N2O4S, the thia­diazine ring adopts a half-chair conformation. The dihedral angle between the benzene ring of the benzothia­diazine ring system and trifluoro­phenyl group is 15.02 (7)°. In the crystal, centrosymmetrically related mol­ecules are linked into dimers via pairs of O—H⋯O hydrogen bonds, generating R 2 2(8) ring motifs. The dimers are further connected into a three-dimensional network by C—H⋯O hydrogen bonds

A scientometric analysis of e-participation research

Purpose - Due to the increasing demand for public services, as a new form of public governance, e-participation has emerged. Scholars from various disciplines have published plenty of research results on e-participation. This paper aims to reveal the research status frontiers directly by mapping knowledge domains. Design/methodology/approach - The authors take 1,322 articles on e-participation published in Web of Science from 2001 to 2017 as research object. They then run the information visualization software CiteSpace to drill deeper into the literature data. Findings - The study found that e-participation research has the obvious interdisciplinary feature; the author and institution cooperation networks with less internal cooperation are relatively sparse; the USA ranks first in the field of e-participation research, followed by the UK, with the other countries lagged behind; and e-participation through social media is gradually becoming the new research focus. Originality/value - Based on the objective data and information visualization technology, the research intuitively reveals the research status and development trend of e-participation

2-[1,1-Dioxo-2-(2,4,5-trifluoro­benz­yl)-2H-1,2-benzothia­zin-4-yl]acetic acid

In the title compound, C17H12F3NO4S, the heterocyclic thia­zine ring adopts a half-chair conformation with the S and the N atoms displaced by −0.608 (3) and 0.105 (3) Å, respectively, from the mean plane formed by the remaining ring atoms. The dihedral angle between the two benzene rings is 36.63 (8)° and the acetic acid group is inclined at right angles [89.78 (8) °] to the mean plane formed by the C atoms of the thia­zine ring. The crystal structure features O—H⋯O and C—H⋯O hydrogen bonds

PO-109 Resistance Training prevents Skeletal Muscle Atrophy Induced by hypoxia through regulating Akt-FoxO1 pathway

Objective Skeletal muscle atrophy induced by hypoxia on the plateau will lead to the decrease of muscle strength and the degeneration of athletic ability. Resistance training is an efficient method to stimulate the growth of muscle and improve protein synthesis. Akt-FoxO1 (Fork head box protein 1) pathway plays a significant role in the regulation of skeletal muscle protein degradation. However, it is not clear whether resistance training could prevent skeletal muscle atrophy induced by hypoxia and what is the regulation role of Akt-FoxO1 pathway. This study built a rat model that resistance training inhibited the skeletal muscle atrophy induced by hypoxia and explore the variation of Akt, FoxO1, Murf and Atrogin-1. Methods 40 male 8-week-old Sprague-Dawley (SD) rats were divided into 4 groups randomly: control group (C), resistance training group (R), hypoxia group (H) and hypoxia resistance training group (HR). H and HR group were placed into simulated 4000m altitude (12.4%, O2%) and R and HR group received ladder resistance training. Their incremental load is calculated by using average body weight. After 4 weeks intervention of hypoxia and resistance training, body composition, wet weight of skeletal muscle (soleus, musculus gastrocnemius,extensor digitorum longus and muscelus biceps brachii) and skeletal muscle cross-sectional area (CSA) were measured. The expression of Akt, FoxO1, Murf and Atrogin-1 were detected by Western blot and RT-PCR.Moreover,immunofluorescence technique was used to locate the phosphorylation of FoxO1.  Results The lean body mass of HR group was significantly higher than H group (P<0.05). The wet weight and CSA of muscelus biceps brachii in HR group were also higher than H group obviously (P<0.05). The results of real-time fluorescence quantitative PCR and western blot showed that the expression of FoxO1 and MuRF of hypoxia group (H group) were significantly higher than control group. However after the intervention of resistance training, the expression of Akt was significantly up-regulate and FoxO1, MuRF were significantly down-regulate. Immunofluorescence technique was used to observe the location of FoxO1 phosphorylation and the expression out of nucleus. Conclusions Resistance training contribute to prevent the occurrence of skeletal muscle atrophy induced by hypoxia and the form of climbing ladder training can stimulate the hypertrophy of biceps in rats. The results revealed that FoxO1 phosphorylation out of nucleus became higher after resistance training. All above revealed that resistance training could inhibit skeletal muscle atrophy induced by hypoxia. Akt promoted FoxO1 phosphorylation may become the molecular mechanisms that resistance training can inhibit the atrophy of skeletal muscle induced by hypoxia

Case report: Surgical repair of congenitally corrected transposition of the great arteries with the guidance of three-dimensional printing

A 10-year-old girl presented with obvious cyanosis, and the saturation of arterial blood oxygen (SpO2) was decreased to 60.5% in the outpatient examination. Computed tomography angiography (CTA) and echocardiography suggested congenitally corrected transposition of the great arteries (ccTGAs), membranous ventricular septal aneurysm (MVSA), atrial septal defect (ASD), severe pulmonary stenosis (PS), and severe tricuspid regurgitation (TR). Due to the complex pathological anatomical structures, the three-dimensional printed model was used for preoperative assessment. After a comprehensive evaluation was completed, the operation was performed by physiological correction under cardiopulmonary bypass, including the resection of MVSA, repair using the bovine pericardial patch for ASD, and linear valvuloplasty of the tricuspid valve. Due to the special anatomical structures of ccTGA, PS was treated by extracardiac pipe technique. After the operation, the patient recovered well, cyanosis disappeared, SpO2 was up to 96%, and the extracardiac pipe was well-functioning without regurgitation or obstruction