LINE: Large-scale Information Network Embedding

This paper studies the problem of embedding very large information networks into low-dimensional vector spaces, which is useful in many tasks such as visualization, node classification, and link prediction. Most existing graph embedding methods do not scale for real world information networks which usually contain millions of nodes. In this paper, we propose a novel network embedding method called the "LINE," which is suitable for arbitrary types of information networks: undirected, directed, and/or weighted. The method optimizes a carefully designed objective function that preserves both the local and global network structures. An edge-sampling algorithm is proposed that addresses the limitation of the classical stochastic gradient descent and improves both the effectiveness and the efficiency of the inference. Empirical experiments prove the effectiveness of the LINE on a variety of real-world information networks, including language networks, social networks, and citation networks. The algorithm is very efficient, which is able to learn the embedding of a network with millions of vertices and billions of edges in a few hours on a typical single machine. The source code of the LINE is available online.Comment: WWW 201

Hyperhomocysteinemia exacerbates cisplatin-induced acute kidney injury in mice by upregulating the expression of endoplasmic reticulum stress protein

Purpose: To determine the effect of hyperhomocysteinemia on cisplatin-induced acute kidney damage, as well as the mechanism involved. Methods: Forty-eight healthy mice were assigned to control and model groups, having 16 and 32 mice, respectively. Cisplatin was intraperitoneally given to model mice at a level of 20 mg/kg. Serum levels of homocysteine (Hcy), BUN and creatinine (Scr) were measured in each group, and changes in kidney coefficient were calculated. Changes in levels of glucose regulatory protein 78 (GRP78) and cysteinedependent aspartate-directed protease-12 (Caspase-12) were determined with immunohistochemistry and Western blot assay. Results: Serum Hcy, BUN, Scr, renal coefficient, and the expression levels of GRP78 and Caspase-12 in kidney of model mice were markedly elevated, relative to control values (p < 0.05). However, relative to model mice, serum Hcy, BUN, Scr, renal coefficient, apoptosis level of renal tubular epithelial cells, and GRP78, Caspase-12 expression levels in renal tissue were significantly increased in the highmethionine intervention group (p < 0.05). Conclusion: Cisplatin induces acute renal injury in mice. Hyperhomocysteinemia may aggravate cisplatin-induced acute renal injury by upregulating the expression of endoplasmic reticulum stress protein

miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation.

Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1). However, the mechanism by which oxidative stress promotes FoxO1 activity is still unclear. Here, we found that miR-181a was upregulated in hydrogen peroxide (

Electrochemical behavior of labetalol at an ionic liquid modified carbon paste electrode and its electrochemical determination

Electrochemical behavior of labetalol (LBT) at carbon paste electrode (CPE) and an ionic liquid1-benzyl-3-methylimidazolehexafluorophosphate([BnMIM]PF6)modified carbon paste electrode([BnMIM]PF6/CPE)in Britton-Robinson buffer solution (pH 2.0) was investigated by cyclic voltammetry (CV) and square wave voltammetric (SWV). The experimental results showed that LBT at both the bare CPE and [BnMIM]PF6/CPEshowed an irreversible oxidation process, but at [BnMIM]PF6/CPE its oxidation peak current increased greatly and the oxidation peak potential shifted negatively. The electrode reaction process is a diffusion-controlled process involving one electron transferring accompanied by a participation of one proton at [BnMIM]PF6/CPE. At the same time, the electrochemical kinetic parameters were determined. Under the optimized electrochemical experimental conditions, the oxidation peak currents were proportional to LBT concentration in the range of 7.0 x 10-6-1.0 x 10-4 mol L-1 with the limit of detection(LOD, S/N=3) of 4.810 x 10-8 mol L-1and the limit of quantification(LOQ, S/N=10) of 1.60 x 10-7 mol L-1, respectively. The proposed method was successfully applied in the determination of LBT content in commercial tablet samples