Bibliometric analysis of corneal transplantation based on PubMed database

AIM:To learn the distribution pattern and worldwide research tendency of corneal transplantation literatures. METHODS: Articles were searched from PubMed of the United States national library database as a data source, to analyze the age distribution, national and regional distribution, dispatch language and author situation included during the year of 2000-2012. The analysis software BICOMB and SPSS 19.0 were used to cluster high-frequency of them. RESULTS: Totally 3 363 literatures were included during the year of 2000-2012, the numbers of them were gradually increased. The literatures were mainly in English, the literatures of our country capacity ranked 4th. There were 50 high frequency subjects, and hot topics were clustered into 3 categories which including corneal endothelium transplantation, treatment for the complications of corneal transplantation, immunological rejection of corneal transplantation. CONCLUSION:There is a growing trend on the research of corneal transplantation. The corneal endothelium transplantation is the hot topics

On the Relation of Hard X-ray Peak Flux and Outburst Waiting Time in the Black Hole Transient GX 339-4

Aims. In this work we re-investigated the empirical relation between the hard X-ray peak flux and the outburst waiting time found previously in the black hole transient GX 339-4. We tested the relation using the observed hard X-ray peak flux of the 2007 outburst of GX 339-4, clarified issues about faint flares, and estimated the lower limit of hard X-ray peak flux for the next outburst. Methods. We included Swift/BAT data obtained in the past four years. Together with the CGRO/BATSE and RXTE/HEXTE light curves, the observations used in this work cover a period of 18 years. Results. The observation of the 2007 outburst confirms the empirical relation discovered before. This strengthens the apparent link between the mass in the accretion disk and the peak luminosity of the brightest hard state that the black hole transient can reach. We also show that faint flares with peak fluxes smaller than about 0.12 crab do not affect the empirical relation. We predict that the hard X-ray peak flux of the next outburst should be larger than 0.65 crab, which will make it at least the second brightest in the hard X-ray since 1991.Comment: 4 pages, 3 figures, accepted by A&

Robust Recovery of Subspace Structures by Low-Rank Representation

In this work we address the subspace recovery problem. Given a set of data samples (vectors) approximately drawn from a union of multiple subspaces, our goal is to segment the samples into their respective subspaces and correct the possible errors as well. To this end, we propose a novel method termed Low-Rank Representation (LRR), which seeks the lowest-rank representation among all the candidates that can represent the data samples as linear combinations of the bases in a given dictionary. It is shown that LRR well solves the subspace recovery problem: when the data is clean, we prove that LRR exactly captures the true subspace structures; for the data contaminated by outliers, we prove that under certain conditions LRR can exactly recover the row space of the original data and detect the outlier as well; for the data corrupted by arbitrary errors, LRR can also approximately recover the row space with theoretical guarantees. Since the subspace membership is provably determined by the row space, these further imply that LRR can perform robust subspace segmentation and error correction, in an efficient way.Comment: IEEE Trans. Pattern Analysis and Machine Intelligenc

Pharmacokinetic/Pharmacodynamic Correlation of Cefquinome Against Experimental Catheter-Associated Biofilm Infection Due to Staphylococcus aureus.

Biofilm formations play an important role in Staphylococcus aureus pathogenesis and contribute to antibiotic treatment failures in biofilm-associated infections. The aim of this study was to evaluate the pharmacokinetic/pharmacodynamic (PK/PD) profiles of cefquinome against an experimental catheter-related biofilm model due to S. aureus, including three clinical isolates and one non-clinical isolate. The minimal inhibitory concentration (MIC), minimal biofilm inhibitory concentration (MBIC), biofilm bactericidal concentration (BBC), minimal biofilm eradication concentration (MBEC) and biofilm prevention concentration (BPC) and in vitro time-kill curves of cefquinome were studied in both planktonic and biofilm cells of study S. aureus strains. The in vivo post-antibiotic effects (PAEs), PK profiles and efficacy of cefquinome were performed in the catheter-related biofilm infection model in murine. A sigmoid E max model was utilized to determine the PK/PD index that best described the dose-response profiles in the model. The MICs and MBICs of cefquinome for the four S. aureus strains were 0.5 and 16 μg/mL, respectively. The BBCs (32-64 μg/mL) and MBECs (64-256 μg/mL) of these study strains were much higher than their corresponding BPC values (1-2 μg/mL). Cefquinome showed time-dependent killing both on planktonic and biofilm cells, but produced much shorter PAEs in biofilm infections. The best-correlated PK/PD parameters of cefquinome for planktonic and biofilm cells were the duration of time that the free drug level exceeded the MIC (fT > MIC, R (2) = 96.2%) and the MBIC (fT > MBIC, R (2) = 94.7%), respectively. In addition, the AUC24h/MBIC of cefquinome also significantly correlated with the anti-biofilm outcome in this model (R (2) = 93.1%). The values of AUC24h/MBIC for biofilm-static and 1-log10-unit biofilm-cidal activity were 22.8 and 35.6 h; respectively. These results indicate that the PK/PD profiles of cefquinome could be used as valuable guidance for effective dosing regimens treating S. aureus biofilm-related infections