The use of platelet-rich plasma in treatment of olfactory dysfunction: A pilot study.

BackgroundOlfactory dysfunction is a prevalent problem with a significant impact on quality of life and increased mortality. Limited effective therapies exist. Platelet-rich plasma (PRP) is an autologous biologic product with anti-inflammatory and neuroprotective effects. This novel pilot study evaluated the role of PRP on olfactory neuroregeneration in patients with hyposmia.MethodsSeven patients who had olfactory loss greater than 6 months in duration, no evidence of sinonasal inflammatory disease, and no improvement with olfactory training and budesonide topical rinses were enrolled in this preliminary study. Patients received a single intranasal injection of PRP into the mucosa of the olfactory cleft. The Sniffin' Sticks olfactory test consisting of threshold, discrimination, and identification measurements (TDI) was administered at the beginning of the study and at 1 and 3 months.ResultsAll patients reported a subjective improvement of their smell shortly after injection but then stabilized. At 3-month post-treatment, two patients with functional anosmia (TDI < 16) did not improve significantly. Five patients with hyposmia (TDI > 16 but <30) showed an improvement with 60% achieving normosmia (TDI > 30) at 3-month follow-up. On average, patients with baseline TDI > 16 improved by 5.85 points with the most significant improvement in the threshold subcomponent. There were no adverse outcomes from intranasal PRP injections.ConclusionPRP appears safe for use in the treatment of olfactory loss, and preliminary data suggest possible efficacy, especially for those with moderate yet persistent loss. Further studies will help determine optimal frequency and duration of use.Level of evidence 2

Hubble Space Telescope images of submillimeter sources: large, irregular galaxies at high redshift

We present new Hubble Space Telescope STIS, high-resolution optical imaging of a sample of 13 submillimeter (submm) luminous galaxies, for which the optical emission has been pinpointed either through radio-1.4 GHz or millimeter interferometry. We find a predominance of irregular and complex morphologies in the sample, suggesting that mergers are likely common for submm galaxies. The component separation in these objects are on average a factor two larger than local galaxies with similarly high bolometric luminosities. The sizes and star formation rates of the submm galaxies are consistent with the maximal star formation rate densities of 20 Msun kpc^{-2} in local starburst galaxies (Lehnert & Heckman 1996). We derive quantitative morphological information for the optical galaxies hosting the submm emission; total and isophotal magnitudes, Petrosian radius, effective radius, concentration, aspect ratio, surface brightness, and asymmetry. We compare these morphological indices with those of other galaxies lying within the same STIS images. Most strikingly, we find ~70% of the submm galaxies to be extraordinarily large and elongated relative to the field population, regardless of optical magnitude. Comparison of the submm galaxy morphologies with those of optically selected galaxies at z~2-3 reveal the submm galaxies to be a morphologically distinct population, with generally larger sizes, higher concentrations and more prevalent major-merger configurations.Comment: 16 pages, 6 figures, scheduled for ApJ, v599, Dec10, 2003. Minor edits. For version with higher resolution figures, see http://www.submm.caltech.edu/~schapman/ms_v3.ps.g

Dynamics of a nanowire superlattice in an ac electric field

With a one-band envelope function theory, we investigate the dynamics of a finite nanowire superlattice driven by an ac electric field by solving numerically the time-dependent Schroedinger equation. We find that for an ac electric field resonant with two energy levels located in two different minibands, the coherent dynamics in nanowire superlattices is much more complex as compared to the standard two-level description. Depending on the energy levels involved in the transitions, the coherent oscillations exhibit different patterns. A signature of barrier-well inversion phenomenon in nanowire superlattices is also obtained.Comment: 14 pages, 4 figure