8,183 research outputs found
Hyperoxidized PRDX3 as a Specific Ferroptosis Marker
The lack of a reliable and specific marker for ferroptosis has hindered the advancement of treatments related to this cell death mechanism toward clinical application. A recent study published in Molecular Cell has identified hyperoxidized peroxiredoxin 3 (PRDX3) as a promising marker for ferroptosis, opening up new avenues for monitoring and targeting ferroptosis in disease treatment
Culture Reference Product Design ---Case Study of Hans J.Wegner China Chair Design
Recent research shows that culture can be referenced as product design inspiration.This culture reference product design method can make cultural inheritance ,at the same time create new modern design value comparing with traditional function improving design method and bionics design approach. So this paper take one case study to explain this culture reference product design value by semantic evaluation in the point of users.The meaning of this research is to prove this design method has positive value judging by users,so in future, this culture reference product design method may be applied in wider range. The case study of this paper is Hans J.Wegner China chair. Author discusses how Hans J.Wegner referenced traditional Chinese chairs into modern chair design,meanwhile find out the value of this reference design method .The method in this paper is mainly on questionnaire investigation﹑semantic differential evaluation(SD)﹑SPSS statistical analysis. The results of this paper include three parts,one is the high possibility of Hans J.Wegner China chair referenced design method from traditional Chinese round-backed armchair .The second one is Hans J.Wegner China chair and five traditional Chinese chair have discrepancy evaluating factors in SD evaluation system , Hans J.Wegner China chair takes aesthetic factor as the first factor because of organic modernism design approach combing with the aesthetical essence of round-backed armchair,while the five traditional Chinese chairs’ first evaluating factor is emotion owning to the ancient Chinese feudal social hierarchy influence of chair symbol for ruling power. The final result is that Hans J.Wegner China chair has positive value in modern design evaluation criteria . With the study of Hans J.Wegner China chair’s culture referenced design ,we can summary that culture reference design is one progressive and valuable modern design method . Keywords: culture reference ,product design , China chair,semantic differential evaluation,positive valu
J-wave syndromes: Brugada and early repolarization syndromes.
A prominent J wave is encountered in a number of life-threatening cardiac arrhythmia syndromes, including the Brugada syndrome and early repolarization syndromes. Brugada syndrome and early repolarization syndromes differ with respect to the magnitude and lead location of abnormal J waves and are thought to represent a continuous spectrum of phenotypic expression termed J-wave syndromes. Despite two decades of intensive research, risk stratification and the approach to therapy of these 2 inherited cardiac arrhythmia syndromes are still undergoing rapid evolution. Our objective in this review is to provide an integrated synopsis of the clinical characteristics, risk stratifiers, and molecular, ionic, cellular, and genetic mechanisms underlying these 2 fascinating syndromes that have captured the interest and attention of the cardiology community in recent years
Cleaved end-face quality of microstructured polymer optical fibres
The cutting of a microstructured polymer optical fibre to form an optical end-face is studied. The effect of the temperature and speed of the cutting blade on the end-face is qualitatively assessed and it is found that for fibres at temperatures in the range 70–90 C, a blade at a similar temperature moving at a speed of less than 0.5 mm/s produces a good quality end-face. The nature of the damage caused by the cutting process was examined and found to vary with fibre temperature, blade quality and cut depth. Thermo-mechanical analysis showed that the drawn material was significantly more visco-elastic than the annealed raw material in the 70-90 C temperature range. The behaviour of the surface damage with cut depth was found to be consistent with the behaviour of a visco-elastic material
Unconventional Superconducting Symmetry in a Checkerboard Antiferromagnet
We use a renormalized mean field theory to study the Gutzwiller projected BCS
states of the extended Hubbard model in the large limit, or the
--- model on a two-dimensional checkerboard lattice. At small
, the frustration due to the diagonal terms of and does not
alter the -wave pairing symmetry, and the negative (positive)
enhances (suppresses) the pairing order parameter. At large , the
ground state has an extended s-wave symmetry. At the intermediate , the
ground state is or -wave with time reversal symmetry broken.Comment: 6 pages, 6 figure
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