Delving into Commit-Issue Correlation to Enhance Commit Message Generation Models

Commit message generation (CMG) is a challenging task in automated software engineering that aims to generate natural language descriptions of code changes for commits. Previous methods all start from the modified code snippets, outputting commit messages through template-based, retrieval-based, or learning-based models. While these methods can summarize what is modified from the perspective of code, they struggle to provide reasons for the commit. The correlation between commits and issues that could be a critical factor for generating rational commit messages is still unexplored. In this work, we delve into the correlation between commits and issues from the perspective of dataset and methodology. We construct the first dataset anchored on combining correlated commits and issues. The dataset consists of an unlabeled commit-issue parallel part and a labeled part in which each example is provided with human-annotated rational information in the issue. Furthermore, we propose \tool (\underline{Ex}traction, \underline{Gro}unding, \underline{Fi}ne-tuning), a novel paradigm that can introduce the correlation between commits and issues into the training phase of models. To evaluate whether it is effective, we perform comprehensive experiments with various state-of-the-art CMG models. The results show that compared with the original models, the performance of \tool-enhanced models is significantly improved.Comment: ASE2023 accepted pape

Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2

Circular RNA RNF13 (circ-RNF13; ID: hsa_circ_0067717) is newly identified to be abnormally upregulated in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) patients. However, its role and mechanism remain to be further annotated. First of all, real-time quantitative PCR (RT-qPCR) was utilized to examine RNA expression, and circ-RNF13 was upregulated in HBV-infected human HCC tissues and HBV-expressing cells (Huh7-HBV and Hep3B-HBV), accompanied with TGFβ-induced factor homeobox 2 (TGIF2) upregulation and microRNA (miR)-424-5p downregulation. Loss-of-functional experiments were performed using MTS assay, colony formation assay, flow cytometry, enzyme-linked immunosorbent assay, transwell assay, and xenograft tumor model. As a result, blocking circ-RNF13 enhanced the apoptosis rate of Huh7-HBV and Hep3B-HBV cells, but inhibited cell proliferation, colony formation, migration, and invasion in vitro, along with suppressed tumor growth in vivo. Besides, RT-qPCR data showed that HBV DNA copies and levels of hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) were diminished by circ-RNF13 knockdown in Huh7-HBV and Hep3B-HBV cells. Mechanistically, circ-RNF13 and TGIF2 could directly interacting with miR-424-5p according to dual-luciferase reporter assay, suggesting that circ-RNF13 and TGIF2 served as competing endogenous RNAs (ceRNAs) for miR-424-5p. Functionally, overexpressing miR-424-5p mimicked and silencing miR-424-5p counteracted the effects of circ-RNF13 depletion in HBV-expressing HCC cells in vitro; TGIF2 restoration partially abrogated the role of miR-424-5p upregulation. In conclusion, circ-RNF13 might sponge miR-424-5p to suppress HBV-associated HCC cells malignant progression and HBV infection by regulating TGIF2, providing a novel insight into the occurrence and treatment of HBV-associated HCC.

Clusterin confers gmcitabine resistance in pancreatic cancer

<p>Abstract</p> <p>Objective</p> <p>To measure clusterin expression in pancreatic cancer tissues and cell lines and to evaluate whether clusterin confers resistance to gmcitabine in pancreatic cancer cells.</p> <p>Methods</p> <p>Immunohistochemistry for clusterin was performed on 50 primary pancreatic cancer tissues and 25 matched backgrounds, and clusterin expression in 5 pancreatic cancer cell lines was quantified by Western blot and PT-PCR. The correlation between clusterin expression level and gmcitabine IC50 in pancreatic cancer cell lines was evaluated. The effect of an antisense oligonucleotide (ASO) against clusterin(OGX-011) on gmcitabine resistance was evaluated by MTT assays. Xenograft model was used to demonstrate tumor growth.</p> <p>Results</p> <p>Pancreatic cancer tissues expressed significantly higher levels of clusterin than did normal pancreatic tissues (<it>P </it>< 0.01). Clusterin expression levels were correlated with gmcitabine resistance in pancreatic cancer cell lines, and OGX-011 significantly decreased BxPc-3 cells resistance to gmcitabine (<it>P </it>< 0.01). <it>In vivo </it>systemic administration of AS clusterin and gmcitabine significantly decreased the s.c. BxPC-3 tumor volume compared with mismatch control ODN plus gmcitabine.</p> <p>Conclusion</p> <p>Our finding that clusterin expression was significantly higher in pancreatic cancer than in normal pancreatic tissues suggests that clusterin may confer gmcitabine resistance in pancreatic cancer cells.</p

Study on the actual particle size, activity concentration, and migration process adsorption behavior of radioactive substances in liquid effluents from nuclear power plants

Radionuclides emitted by nuclear power plants may have effects on the environment and public health. At present, research on radioactive material effluent in the industry mainly focuses on the treatment of radioactive effluent and the particle size distribution of the primary circuit. There is little research on the particle size of radioactive material during the migration process outside the primary circuit system, as well as the flocculation precipitation and other enrichment phenomena during the collection process of effluent. Therefore, this study relies on the sampling of effluent from an in-service nuclear power plant to measure its radioactivity level by particle size range. At the same time, the mixing process of effluent is simulated in the laboratory to simulate the adsorption behavior of effluent during the migration process. It was found that in the activity concentration of detectable radioactive nuclides in the effluent samples, more than 95% of radioactive nuclides exist in the liquid with particle sizes less than 0.1μm, while particle sizes greater than 0.45 μm account for less than 5%. After the sample was filtered by the demineralizer, the radioactive activity decreased. The flocculation precipitation in the waste liquid of the waste water recovery system has a certain contribution to the enrichment of nuclides. With the extension of time, the enrichment of transition elements such as cobalt and manganese is particularly obvious, so that it is distributed in the liquid again with a large particle size. In addition, large particle size substances such as colloids in seawater have a certain adsorption effect on radionuclides, which will lead to its aggregation effect again

Experimental study and chemical affinity model on the inhibition of CO2 gas hydrate formation

Natural gas and water can form complex cage crystals in oil and gas pipelines under certain conditions. The natural gas hydrate formed after crystal clustering can block the pipeline and affect the operation efficiency of the pipeline, and even cause equipment damage, bringing economic and security problems to enterprises. In the present study, we experimentally investigated the inhibition of CO2 formation hydrate using attapulgite (ATP) and glucose (GLC). The kinetic influence on the formation of CO2 hydrate by the complex pairing of kinetic inhibitor ATP is conducted under the working conditions of 277.15 K and 3.5 MPa. The effect of compound inhibitors on the temperature and pressure conditions, growth process and gas consumption of hydrate formation are revealed. The chemical affinity model of CO2 hydrate formation under a compound inhibitor system is derived and established based on experimental studies. The results show that the combination of GLC and ATP can inhibit the formation of CO2 hydrate to varying degrees, prolong the induction time of hydrate, and reduce the consumption of CO2. The optimized experimental studies demonstrate that the best inhibitory compound system is 15 mg/mL GLC + 1.00 mg/mL ATP. Compared with the pure water system and single 15 mg/mL GLC system, the induction time is extended by 122.61% and 122.23%, while the gas consumption is reduced by 23.72% and 3.41%. The results provide new ideas and methods for the prediction of hydrate formation in the compound inhibitor system for the safe operation of oil and gas pipelines

Human Migration through Bottlenecks from Southeast Asia into East Asia during Last Glacial Maximum Revealed by Y Chromosomes

Molecular anthropological studies of the populations in and around East Asia have resulted in the discovery that most of the Y-chromosome lineages of East Asians came from Southeast Asia. However, very few Southeast Asian populations had been investigated, and therefore, little was known about the purported migrations from Southeast Asia into East Asia and their roles in shaping the genetic structure of East Asian populations. Here, we present the Y-chromosome data from 1,652 individuals belonging to 47 Mon-Khmer (MK) and Hmong-Mien (HM) speaking populations that are distributed primarily across Southeast Asia and extend into East Asia. Haplogroup O3a3b-M7, which appears mainly in MK and HM, indicates a strong tie between the two groups. The short tandem repeat network of O3a3b-M7 displayed a hierarchical expansion structure (annual ring shape), with MK haplotypes being located at the original point, and the HM and the Tibeto-Burman haplotypes distributed further away from core of the network. Moreover, the East Asian dominant haplogroup O3a3c1-M117 shows a network structure similar to that of O3a3b-M7. These patterns indicate an early unidirectional diffusion from Southeast Asia into East Asia, which might have resulted from the genetic drift of East Asian ancestors carrying these two haplogroups through many small bottle-necks formed by the complicated landscape between Southeast Asia and East Asia. The ages of O3a3b-M7 and O3a3c1-M117 were estimated to be approximately 19 thousand years, followed by the emergence of the ancestors of HM lineages out of MK and the unidirectional northward migrations into East Asia