Investigation of arylated arsenic compounds as cardiac stimulants

The paper summarizes the literature data on the biological activity of organoarsenic derivatives, describes compounds with useful biological properties necessary for their use in medicines, and presents the results of the study of arylated arsenic compounds as stimulants of cardiac activity. A stable view of the high toxicity of organoarsenic compounds interfered with their practical use. Existing data on the biological properties of organoarsenic compounds do not give a complete and unambiguous idea of the possibilities of their application. In this connection, this paper was aimed at generalizing the available data on the biological activity of organoarsenic derivatives and obtaining compounds with practically useful properties suitable for their use in medicine. The biological significance of arsenic in the body is determined by its participation in the metabolism. He plays an important role in the enzymatic reactions of tissue respiration. In the light of these concepts, its therapeutic significance is regarded. The action of arsenic was considered as a result of its influence on the vessels through the sympathetic nervous system. With therapeutic doses of arsenic, this is expressed in the expansion of blood vessels and contributes to the improvement of trophism. Administration of high doses results in stagnation of blood, inflammation and even necrosis of the walls of the capillaries

The kabachnik-fields and pudovik reactions on the basis of E,Z-citral and its imines and (R,S)-citronellal

The Kabachnik-Fields reaction of E,Z-citral with diethyl phosphite in the presence of isobutylamine has been found to form α-aminophosphonates. The Pudovik reactions of diethyl phosphite with prenyl imines prepared on the basis of E,Z-citral with isobutylamine also allowed us to obtain the same α-aminophosphonates. We have managed to synthesize α- aminophosphonates by the reaction of O,O-dialkyl trimethylsilyl phosphites with prenyl imines in the presence of water or diethylamine. α- Aminophosphonates were also synthesized by the reaction of diethyl phosphite with (R,S)-citronellal in the presence of alkylamines. α-Aminophosphonates obtained showed bacteriostatic activity against Staphylococcus aureus and Bacillus cereus. © 2012 Wiley Periodicals, Inc

O,O-dialkyldithiophosphoric acids in the reactions with nonactivated α-olefins

Reactions of O,O-dialkyl dithiophosphoric acids with hexadec-1-ene, octadec-1-ene, and also 2-methylpentadec-1-ene and 2-methylheptadec-1-ene as impurities in commercial samples of hexadec-1-ene and octadec-1-ene, and pure 2-methylpent-1-ene were studied in the presence of zinc chloride and ultrasound irradiation. © 2013 Copyright Taylor and Francis Group, LLC

Development of methods of phosphorylation of citral by medial and acidic phosphites

The reactions of trimethyl phosphite with citral in the presence of acetic acid, triphenyl phosphite with citral in the presence of water and trimethyl phosphite with citral in the presence of water and triethylamine in the methanol solution were studied. On the basis of these studies, dienyl 1-hydroxyphosphonates were obtained. A convenient method of synthesizing unsaturated 1-hydroxyphosphonates was developed on the basis of reaction of dialkyl phosphites with citral in the presence of triethylamine in molar ratio 4:2:8 in alcohol solutions

Investigation of arylated arsenic compounds as cardiac stimulants

The paper summarizes the literature data on the biological activity of organoarsenic derivatives, describes compounds with useful biological properties necessary for their use in medicines, and presents the results of the study of arylated arsenic compounds as stimulants of cardiac activity. A stable view of the high toxicity of organoarsenic compounds interfered with their practical use. Existing data on the biological properties of organoarsenic compounds do not give a complete and unambiguous idea of the possibilities of their application. In this connection, this paper was aimed at generalizing the available data on the biological activity of organoarsenic derivatives and obtaining compounds with practically useful properties suitable for their use in medicine. The biological significance of arsenic in the body is determined by its participation in the metabolism. He plays an important role in the enzymatic reactions of tissue respiration. In the light of these concepts, its therapeutic significance is regarded. The action of arsenic was considered as a result of its influence on the vessels through the sympathetic nervous system. With therapeutic doses of arsenic, this is expressed in the expansion of blood vessels and contributes to the improvement of trophism. Administration of high doses results in stagnation of blood, inflammation and even necrosis of the walls of the capillaries

The kabachnik-fields and pudovik reactions on the basis of E,Z-citral and its imines and (R,S)-citronellal

The Kabachnik-Fields reaction of E,Z-citral with diethyl phosphite in the presence of isobutylamine has been found to form α-aminophosphonates. The Pudovik reactions of diethyl phosphite with prenyl imines prepared on the basis of E,Z-citral with isobutylamine also allowed us to obtain the same α-aminophosphonates. We have managed to synthesize α- aminophosphonates by the reaction of O,O-dialkyl trimethylsilyl phosphites with prenyl imines in the presence of water or diethylamine. α- Aminophosphonates were also synthesized by the reaction of diethyl phosphite with (R,S)-citronellal in the presence of alkylamines. α-Aminophosphonates obtained showed bacteriostatic activity against Staphylococcus aureus and Bacillus cereus. © 2012 Wiley Periodicals, Inc

The kabachnik-fields and pudovik reactions on the basis of E,Z-citral and its imines and (R,S)-citronellal

The Kabachnik-Fields reaction of E,Z-citral with diethyl phosphite in the presence of isobutylamine has been found to form α-aminophosphonates. The Pudovik reactions of diethyl phosphite with prenyl imines prepared on the basis of E,Z-citral with isobutylamine also allowed us to obtain the same α-aminophosphonates. We have managed to synthesize α- aminophosphonates by the reaction of O,O-dialkyl trimethylsilyl phosphites with prenyl imines in the presence of water or diethylamine. α- Aminophosphonates were also synthesized by the reaction of diethyl phosphite with (R,S)-citronellal in the presence of alkylamines. α-Aminophosphonates obtained showed bacteriostatic activity against Staphylococcus aureus and Bacillus cereus. © 2012 Wiley Periodicals, Inc

The kabachnik-fields and pudovik reactions on the basis of E,Z-citral and its imines and (R,S)-citronellal

The Kabachnik-Fields reaction of E,Z-citral with diethyl phosphite in the presence of isobutylamine has been found to form α-aminophosphonates. The Pudovik reactions of diethyl phosphite with prenyl imines prepared on the basis of E,Z-citral with isobutylamine also allowed us to obtain the same α-aminophosphonates. We have managed to synthesize α- aminophosphonates by the reaction of O,O-dialkyl trimethylsilyl phosphites with prenyl imines in the presence of water or diethylamine. α- Aminophosphonates were also synthesized by the reaction of diethyl phosphite with (R,S)-citronellal in the presence of alkylamines. α-Aminophosphonates obtained showed bacteriostatic activity against Staphylococcus aureus and Bacillus cereus. © 2012 Wiley Periodicals, Inc

O,O-dialkyldithiophosphoric acids in the reactions with nonactivated α-olefins

Reactions of O,O-dialkyl dithiophosphoric acids with hexadec-1-ene, octadec-1-ene, and also 2-methylpentadec-1-ene and 2-methylheptadec-1-ene as impurities in commercial samples of hexadec-1-ene and octadec-1-ene, and pure 2-methylpent-1-ene were studied in the presence of zinc chloride and ultrasound irradiation. © 2013 Copyright Taylor and Francis Group, LLC

O,O-dialkyldithiophosphoric acids in the reactions with nonactivated α-olefins

Reactions of O,O-dialkyl dithiophosphoric acids with hexadec-1-ene, octadec-1-ene, and also 2-methylpentadec-1-ene and 2-methylheptadec-1-ene as impurities in commercial samples of hexadec-1-ene and octadec-1-ene, and pure 2-methylpent-1-ene were studied in the presence of zinc chloride and ultrasound irradiation. © 2013 Copyright Taylor and Francis Group, LLC