Seasonal variation of moisture transport in polar regions and the relation with annular modes

Climatological seasonal variations of moisture transport and the interannual variations associated with the annular modes in the Arctic and Antarctic regions are investigated using 15-year ECMWF reanalysis data. Over the Arctic, there are strong moisture inflows from the Atlantic and Pacific in all seasons. Over the Antarctic, a strong moisture inflow exists around the Antarctic Peninsula in all seasons and another strong inflow exists over the Bellingshausen Sea and the Amundsen Sea in austral autumn and winter. Transient moisture flux is dominant over stationary flux and transient flux variation mainly controls the seasonal variation of precipitation minus evaporation(P-E) in both regions. The seasonal variations of P-E show a summer maximum in the Arctic and a winter maximum in the Antarctic. It is mainly governed by the seasonal variation of precipitable water variation in the Arctic and transient eddy activity in the Antarctic. The zonal mean poleward and eastward moisture fluxes in high latitudes are positively correlated with annular modes in both regions. Positive polarity of the Arctic Oscillation is associated with enhanced moisture inflow from the Atlantic, while positive polarity of the Antarctic Oscillation is associated with enhanced moisture inflow west of the Antarctic Peninsula

Atmospheric hydrological cycles in the Arctic and Antarctic during the past four decades

Atmospheric hydrological cycles over the Arctic and Antarctic have been investigated in the previous studies and there are some similarity and dissimilarity in the two polar regions. The Arctic and Antarctic are areas of moisture flux convergence through the year. So the precipitation (P) exceeds the evaporation (E) and the net precipitation (P-E) is positive. Therefore, the atmospheric moisture transport is a primary input of water into the polar regions. Meanwhile the climatological seasonal cycles of P-E over these regions are dominated by transient moisture flux associated with cyclone activities, the interannual variations are governed by the stationary flux associated with the Arctic Oscillation and the Antarctic Oscillation (AAO). In addition, recent climate changes influence the polar hydrological cycles. Our analyses using an atmospheric reanalysis up to recent years indicated that there were no significant long-term changes in the poleward moisture transport into both the Arctic and Antarctic during 1979-2016. On the other hand, the water vapor (precipitable water) were clearly increasing over the Arctic and gradually decreasing over the Antarctic during the same period. As expected, the increasing trend of water vapor was due to the large warming over the Arctic. There were two reasons for the gradually decreasing trend of water vapor over the Antarctic. The first one was the positive trend of AAO in summer and the second was deepening trend of the Amundsen low in autumn. The trends in water vapor and temperature during the past 38 years further suggest that both polar regions were getting dryer in several seasons. The trend, however, needs to be confirmed by follow-up climatological analyses

Effect of the particle brush on polishing performance of surface magnetic polishing using slurry circulation system

ArticleProceedings of the 6th international conference on progress of machining technology. CHEN D. NARUTAKI N. YAMANE. YCHEN W. OCHI A. ed. Xi’an in China, 2002-09, AVIATION INDUSTRY PRESS， 334-339 (2002)conference pape

Study on particle-brush in magnetic field assisted machining : Finishing characteristics of grooves

ArticleProceedings of International Conference on Leading Edge Manufacturing in 21st Century (LEM21). Niigata in Japan, 2003-11, The Japan Society of Mechanical Engineers，385-390(2003)conference pape

Availability of a remote online hemodynamic monitoring system during treatment in a private dental office for medically high-risk patients

The importance of systemic management to prevent accidents is increasing in dentistry because co-morbid illnesses in an aging society and invasive surgical procedures are increasing. In this prefecture, a new medical system called the remote online hemodynamic monitoring system (ROHMs) was started in 2001. Eight private dental offices participated in this trial. When dental practitioners feel the risk of a dental procedure, they can contact via ROHMs to this hospital. Then, the hemodynamic data (blood pressure, heart rate, ECG, SpO2, and RPP) of the patient in the clinic can be transmitted here via the internet, and the images and the voice can be transmitted as well. The availability of this system was assessed in 66 patients (98 cases). The most frequent complications were hypertension, heart disease, and diabetes mellitus. Systemic management included monitoring during the dental procedure (71.4%), checking vital signs after an interview (15.3%), and monitoring under sedation (13.3%). There were 35.7% of all cases where an unscheduled procedure was necessary for the systemic management. Based on a questionnaire, the majority of the patients felt relieved and safe. This system creates a situation where a specialist is almost present during the procedure. This system will provide significant assistance for future medical cooperation for risk management

Atypical fracture of the tibial plateau

Objective : Only a few cases of insufficiency fractures of the tibial plateau following bisphosphonate use have been reported. The authors report a case with bisphosphonate (BP) -related atypical insufficiency fracture of tibial plateau, which developed delayed union. Patient : A 65-year-old Japanese woman presented with left knee pain without any trauma. She had a 5-year history of risedronate use for primary osteoporosis. Initial X-rays were unremarkable, but magnetic resonance imaging (MRI) confirmed an insufficiency fracture at the left tibial plateau at 3 weeks after the initial visit. Risedronate treatment was stopped because we diagnosed her with a BP-related atypical insufficiency fracture of the tibial plateau. She was treated with rest, a lateral wedge insole and protective weight-bearing with a T-cane for 3 months. Result : At 3-month follow-up, the patient still had a pain and a delayed healing on radiographs. Six months later, X-rays showed that the fracture site had a sclerotic change, but MRI revealed delayed union. At 8-month follow-up, the fracture was healed without any symptoms. Conclusion : All clinicians need to be aware of the delayed healing of atypical insufficiency fracture related with prolonged BP use

Gene suppression via U1 small nuclear RNA interference (U1i) machinery using oligonucleotides containing 2′-modified-4′-thionucleosides

AbstractGene suppression via U1 small nuclear RNA interference (U1i) is considered to be one of the most attractive approaches, and takes the place of general antisense, RNA interference (RNAi), and anti-micro RNA machineries. Since the U1i can be induced by short oligonucleotides (ONs), namely U1 adaptors consisting of a ‘target domain’ and a ‘U1 domain’, we prepared adaptor ONs using 2′-modified-4′-thionucleosides developed by our group, and evaluated their U1i activity. As a result, the desired gene suppression via U1i was observed in ONs prepared as a combination of 2′-fluoro-4′-thionucleoside and 2′-fluoronucleoside units as well as only 2′-fluoronucleoside units, while those prepared as combination of 2′-OMe nucleoside/2′-OMe-4′-thionucleoside and 2′-fluoronucleoside units did not show significant activity. Measurement of Tm values indicated that a higher hybridization ability of adaptor ONs with complementary RNA is one of the important factors to show potent U1i activity

Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator

手術負担の少ない内視鏡による心臓表面への細胞シート移植デバイスを開発 --心臓再生医療への応用を目指して--. 京都大学プレスリリース. 2020-11-20.Introduction: Considering higher risks of candidates for cardiac regenerative therapy with compromised cardiac function, it is anticipated to develop less invasive surgical procedures. In the present study, we aimed to develop a prototype of totally endoscopic cell sheet delivery device and evaluate the surgical technique for epicardial cell sheet placement using three-dimensional (3D) printed simulators based on human computed tomography data. Methods: We designed an endoscopic cell sheet delivery device with outer and inner frame with self-expandable applicator which can be opened in thoracic cavity. We launched spout line to provide liquids on the applicator surface and tension line to gently bend the applicator dorsally. We prepared human mesenchymal stem cell (MSC) sheets and compared wet/dry conditions of 3D printed heart/porcine heart and applicator to identify suitable conditions for cell sheet transplantation. Finally we validated the feasibility of endoscopic transplantation to anterior and lateral wall of left ventricle using 3D printed simulators. Results: Moist condition of both 3D printed heart/porcine heart surface and applicator at transplantation yielded highest successful rate (100%, p = 0.0197). For both endoscopic transplantation sites, MSC sheets were successfully deployed. The procedure duration was 157 ± 23 s for anterior wall and 123 ± 13 s for the lateral wall in average, respectively. Conclusions: We developed a novel prototype of endoscopic cell sheet delivery device for minimally-invasive cardiac regenerative therapy utilizing a 3D printed simulator. The commercialization of the prototype may provide a safe minimally-invasive method to deliver potential cardiac regenerative therapy in the future