Hydrogen and oxygen isotope ratios of thermal waters of Okayama Prefecture, Japan

Hydrogen and oxygen isotope rations of thermal waters from 46 spas in Okayama Prefecture range from -62.6 to -29.2% in δD and from -10.0 to -4.4% in δ18O, respectively. The isotope rations indicate that all but one of the thermal water in Okayama prefecture are meteoric in origin. The Ofuku thermal water is the only exception, which is probably a mixture of seawater and meteoric water with the ratio of about 1. Sulfur isotope rations of dissolvel sulfate in the thermal waters range from -6.2 ti 59.3% in δ34S. The high δ34S values observed in some thermal waters may be due to bacterial reduction of sulfate

The Hosotani Mechanism in Bulk Gauge Theories with an Orbifold Extra Space S^1/Z_2

We pursue the possibility of the scenario in which the Higgs field is identified with the extra-space component of a bulk gauge field. The space-time we take is M$^{4}$ $\otimes$ S$^1$/Z$_2$. We show that a non-trivial Z$_2$-parity assignment allows some of the extra-space component to have radiatively induced VEV, which strongly modifies the mass spectrum and gauge symmetry of the theory, realized by oribifolding. In particular we investigate the dynamical mass generation of zero-mode fermion and spontaneous gauge symmetry breaking due to the VEV. The gauge theories we adopt are a prototype model SU(2) and SU(3) model, of special interest as the realistic minimal scheme to incorporate the standard model SU(2) $\times$ U(1).Comment: 16 pages 3 figure

ハンレイ ニ ミル サガイテキ シャカイ ブンカツ ト サイケンシャ ロウドウシャ ノ ホゴ ジギョウ ショウケイ ヲ メグル カイシャクロン ノ ゲンカイ

末永敏和教授退職記念

The Cell Cycle Independence of HIV Infections Is Not Determined by Known Karyophilic Viral Elements

Human immunodeficiency virus and other lentiviruses infect cells independent of cell cycle progression, but gammaretroviruses, such as the murine leukemia virus (MLV) require passage of cells through mitosis. This property is thought to be important for the ability of HIV to infect resting CD4+ T cells and terminally differentiated macrophages. Multiple and independent redundant nuclear localization signals encoded by HIV have been hypothesized to facilitate migration of viral genomes into the nucleus. The integrase (IN) protein of HIV is one of the HIV elements that targets to the nucleus; however, its role in nuclear entry of virus genomes has been difficult to describe because mutations in IN are pleiotropic. To investigate the importance of the HIV IN protein for infection of non-dividing cells, and to investigate whether or not IN was redundant with other viral signals for cell cycle-independent nuclear entry, we constructed an HIV-based chimeric virus in which the entire IN protein of HIV was replaced by that of MLV. This chimeric virus with a heterologous IN was infectious at a low level, and was able to integrate in an IN-dependent manner. Furthermore, this virus infected non-dividing cells as well as it infected dividing cells. Moreover, we used the chimeric HIV with MLV IN to further eliminate all of the other described nuclear localization signals from an HIV genome—matrix, IN, Viral Protein R, and the central polypurine tract—and show that no combination of the virally encoded NLS is essential for the ability of HIV to infect non-dividing cells

血液型A抗原/B抗原応答B細胞はカルシニューリンインヒビターの感受性が異なる

広島大学(Hiroshima University)博士(医学)Doctor of Philosophy in Medical Sciencedoctora

ジンシン ショウガイ ホショウ ホケン ニ カンスル イチコウサツ

末永敏和教授退職記念

ジギョウケイショウ ガイシャ セキニンキセイ ノ リッポウロンテキ ケントウ ショウゴウゾクヨウ キジュン カ サガイセイ キジュン カ

論

Fish assemblages associated with three types of artificial reefs: density of assemblages and possible impacts on adjacent fish abundance

We evaluated the effectiveness of wooden artificial reefs (ARs) as fish habitat. Three types of ARs, made of cedar logs, broadleaf tree logs, and PVC pipes, respectively, were deployed in triplicate at 8-m depth off Maizuru, Kyoto Prefecture, Sea of Japan, in May 2004. Fish assemblages associated with each of the nine ARs were observed by using SCUBA twice a month for four years. Fish assemblages in the adjacent habitat were also monitored for two years before and four years after reef deployment. In the surveyed areas (ca. 10 m2) associated with each of the cedar, broadleaf, and PVC ARs, the average number of fish species was 4.14, 3.49, and 3.00, and the average number of individuals was 40.7, 27.9, and 20.3, respectively. The estimated biomass was also more greater when associated with the cedar ARs than with other ARs. Visual censuses of the habitat adjacent to the ARs revealed that the number of fish species and the density of individuals were not affected by the deployment of the ARs. Our results support the superiority of cedar as an AR material and indicate that deployment of wooden ARs causes no reduction of fish abundance in adjacent natural reefs

Preparation of Some α-Substituted Cyclopropanecarboxylic Acids via Dichlorocarbene

Some α, β-unsaturated esters (1), including trans-crotonate, trans-α-methoxycrotonate, irans-α-fluorocrotonate, trans-cinnamate, trans-α-chlorocinnamate, cis- and trans-α-fluorocinnamates, fumarate, and maleate, were allowed to react with dichlorocarbene, generated by the thermal decomposition of sodium trichloroacetate at 120-160°C, to give the corresponding β, β-dichlorocyclopropanecarboxylates (2) in fair to good yields (38-88%). The additions of dichlorocarbene to these esters were stereospecific. A similar reaction of n-butyl acrylate gave only a very low yield (6%) of the dichlorocarbene adduct, probably because of the accompanying polymerization of the starting ester. The reduction of 1-unsubstituted or 1-methoxysubstituted 2, 2-dichloro-3-methylcyclopropanecarboxylate with tri-n-butyltin hydride at 90°C yielded both the completely reduced (3) and the partially reduced esters (4 and 5). That of 1-fluoro-substituted ester gave only the completely reduced product. These cyclopropanecarboxylates (2 and 3) were hydrolyzed with potassium hydroxide to give the corresponding free acids (6 and 7) in good yields (72-92%). The properties (bp, mp, nᴅ, pmr spectral data, etc.) of the cyclopropanecarboxylic acids and esters thus prepared are described