1 research outputs found
Cationic Poly(2-aminoethylmethacrylate) and Poly(<i>N</i>‑(2-aminoethylmethacrylamide) Modified Cellulose Nanocrystals: Synthesis, Characterization, and Cytotoxicity
Cellulose nanocrystals (CNCs) continue
to gain increasing attention
in the materials community as sustainable nanoparticles with unique
chemical and mechanical properties. Their nanoscale dimensions, biocompatibility,
biodegradability, large surface area, and low toxicity make them promising
materials for biomedical applications. Here, we disclose a facile
synthesis of poly(2-aminoethylmethacrylate) (poly(AEM)) and poly(<i>N</i>-(2-aminoethylmethacrylamide) (poly(AEMA)) CNC brushes
via the surface-initiated single-electron-transfer living radical
polymerization technique. The resulting modified CNCs were characterized
for their chemical and morphological features using a combination
of analytical, spectroscopic, and microscopic techniques. Zeta potential
measurements indicated a positive surface charge, and further proof
of the cationic nature was confirmed by gold deposition as evidenced
by electron microscopy. The cytotoxicity of these cationic modified
CNCs was evaluated utilizing a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide (MTT) assay in two different cell lines, J774A1 (mouse monocyte
cells) and MCF-7 (human breast adenocarcinoma cells). The results
indicated that none of the cationic modified CNCs decreased cell viability
at low concentrations, which could be suitable for biomedical applications