試験管内共存培養系を用いた血管内皮細胞‐周皮細胞間相互作用の解析: 内皮細胞の増殖、機能、傷害における周皮細胞の役割と内皮細胞由来周皮細胞増殖因子の実体の解明

取得学位 : 博士（医学）, 学位授与番号 : 医博甲第1075号, 学位授与年月日：平成5年3月25日,学位授与年：199

A double peak of the coercive force near the compensation temperature in the rare earth iron garnets

The behavior of the coercive force, Hc, of ferrimagnets near the compensation temperature, Tcomp, for polycrystalline rare earth iron garnets R3Fe5O12 (R = Gd, Tb, Dy, Ho and Er) has been studied in detail. The present experimental results have verified the double peak in Hc near Tcomp for these rare earth iron garnets R3Fe5O12. For Dy3Fe5O12, the experimental values are Tcomp = 224 K, Hc (max) = 600 Oe at Tcomp ±δ K andδ ≈ 10 K. The two peaks of Hc arise at 214 and 232 K. The appearance of the double peak of Hc is an intrinsic and characteristic property for R3Fe5O12. The results can be understood on the basis of a simple model. The hysteresis loop in the magnetization is caused by rotation of single domain under the influence of crystalline anisotropy rather than domain wall displacements of the multi-domain structure. The rare earth ion behaves as superimposed paraprocess under the influence of weak exchange field produced by iron sublattices and an external magnetic field

Magnetic susceptibility of vanadium garnets NaPb2Co2V3O12 and NaPb2Ni2V3O12

Vanadium garnets NaPb2Co2V3O12 and NaPb2Ni2V3O12 have been successfully synthesized. The X-ray diffraction experiments indicate that these compounds have the garnet structure of cubic symmetry of space group Ia3?d(Oh10) with the lattice constant of 12.742 Å (NaPb2Co2V3O12) and 12.666 Å (NaPb2Ni2V3O12), respectively. The magnetic susceptibility of NaPb2Ni2V3O12 shows the Curie Weiss paramagnetic behavior between 4.2 and 350 K. The effective magnetic moment μeff of NaPb2Ni2V3O12 is 3.14 μB due to Ni2+ ion at A-site and the Weiss constant is -3.67 K (antiferromagnetic sign). For NaPb2Co2V3O12, the simple Curie Weiss law cannot be applicable. The ground state is the spin doublet E2(t26e) and the first excited state is spin quartet T4(t25e), according to Tanabe-Sugano energy diagram on the basis of octahedral crystalline symmetry. This excited spin quartet state just a bit higher than ground state influences strongly the complex temperature dependence of magnetic susceptibility for NaPb2Co2V3O12

Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property

Background: We have previously found that atorvastatin decreases liver injury markers in patients with nonalcoholic steatohepatitis. However, how atorvastatin treatment ameliorates the disease activity in nonalcoholic steatohepatitis patients remains unknown. Aims: We examined here which anthropometric, metabolic and inflammatory variables were improved and related with amelioration of disease activity in atorvastatin-treated nonalcoholic steatohepatitis patients. Methods: Forty-two biopsy-proven nonalcoholic steatohepatitis patients with dyslipidemia were enrolled. Patients were treated with atorvastatin (10 mg/day) for 12 months. Results: Atorvastatin significantly decreased liver transaminase, gamma-glutamyl transpeptidase, low-density lipoprotein-cholesterol, triglycerides, type IV collagen, and tumour necrosis factor-alpha levels, whilst it increased adiponectin and high-density lipoprotein-cholesterol. Atorvastatin improved nonalcoholic fatty liver disease activity score and increased liver to spleen density ratio. Multiple stepwise regression analysis revealed that gamma-glutamyl transpeptidase, tumour necrosis factor-alpha and liver to spleen density ratio ( inversely) were independently associated with nonalcoholic fatty liver disease activity score. Aspartate aminotransferase, low-density lipoprotein-cholesterol and nonalcoholic fatty liver disease activity score were independent determinants of decreased liver to spleen density ratio. Conclusion: The present study suggests that atorvastatin improves the disease activity of nonalcoholic steatohepatitis partly via its tumour necrosis factor-alpha-lowering property. (C) 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved

Ferrimagnetic order in the mixed garnet (Y1-xGdx)3Fe5O12

Ferrimagnetic order in the mixed rare-earth iron garnet (Y1-xGdx)3Fe5O12 system has been reinvestigated to cover the temperature range 5.0 to 700 K. The magnetization versus temperature exhibits a systematic variation with changing concentration x. The ferric-ion exchange coupling is strong enough to determine the Curie temperature ≈559 K for all the values x. The compensation temperature at which the magnetization crosses zero (shows the minimum) demonstrates the applicability of the three-sublattice model. The magnetic moment at 5.0 K indicates reasonable agreement with the relation nB = |21x-5.0|μB for the (Y1-xGdx)3Fe5O12 system. The compensation temperature decreases with decreasing x from 1.0 and reaches zero near x = 0.24. An enlargement of coercive force in the hysteresis loop for the low-field M-H curve is clearly seen in near the compensation temperature, indicating that a single domain is formed and the rotation of this single domain occurs without building up a multidomain structur

Recent topics of infrared effective lattice QCD

Three topics concerning infrared effective lattice QCD are discussed. (1)Perfect lattice action of infrared SU(3) QCD and perfect operators for the static potential are analytically given when we assume two-point monopole interactions alone. The assumption seems to be justified from numerical analyses of pure SU(3) QCD in maximally abelian gauge. (2)Gauge invariance of monopole dominance can be proved theoretically if the gauge invariance of abelian dominance is proved. The gauge invariance of monopole condensation leads us to confinement of abelian neutral but color octet states after abelian projection. (3)A stochastic gauge fixing method is developed to study the gauge dependence of the Abelian projection, which interpolates between the maximally abelian (MA) gauge and no gauge fixing. Abelian dominance for the heavy quark potential holds even in the gauge which is far from Maximally Abelian one.Comment: LATTICE99(Poster),3 pages, LaTeX with 4 eps figure

Expression and Localization of α-amylase in the Submandibular and Sublingual Glands of Mice

In the major salivary glands of mice, acinar cells in the parotid gland (PG) are known to be the main site for the production of the digestive enzyme α-amylase, whereas α-amylase production in the submandibular gland (SMG) and sublingual gland (SLG), as well as the cell types responsible for α-amylase production, has been less firmly established. To clarify this issue, we examined the expression and localization of both the mRNA and protein of α-amylase in the major salivary glands of male and female mice by quantitative and histochemical methods. α-amylase mRNA levels were higher in the order of PG, SMG, and SLG. No sexual difference was observed in α-amylase mRNA levels in the PG and SLG, whereas α-amylase mRNA levels in the female SMG were approximately 30% those in the male SMG. Using in situ hybridization and immunohistochemistry, signals for α-amylase mRNA and protein were found to be strongly positive in acinar cells of the PG, serous demilune cells of the SLG, and granular convoluted tubule (GCT) cells of the male SMG, weakly positive in seromucous acinar cells of the male and female SMG, and negative in mucous acinar cells of the SLG. These results clarified that α-amylase is produced mainly by GCT cells and partly by acinar cells in the SMG, whereas it is produced exclusively by serous demilune cells in the SLG of mice