ワタシ ノ コウギ テニス プレーヤー ワ ナゼ ウインブルドン ニ トクベツ ノ オモイ オ モツ ノカ

平成12年度の総合科目の中に、体育センターではスポーツその遺産-The great of sports-を開講した。開講の趣旨は、スポーツに関する様々な事柄の中で、後世に残ると思われるもの、あるいは後世に語り継ぐに値するものと思われるものを紹介あすることであった。 ..

Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation

When a replicative DNA polymerase stalls upon encountering a lesion on the template strand, it is relieved by other low-processivity polymerase(s), which insert nucleotide(s) opposite the lesion, extend by a few nucleotides, and dissociate from the 3′-OH. The replicative polymerase then resumes DNA synthesis. This process, termed translesion replication (TLS) or replicative bypass, may involve at least five different polymerases in mammals, although the participating polymerases and their roles have not been entirely characterized. Using siRNAs originally designed and an alkaline sucrose density gradient sedimentation technique, we verified the involvement of several polymerases in ultraviolet (UV) light-induced TLS in HeLa cells. First, siRNAs to Rev3 or Rev7 largely abolished UV-TLS, suggesting that these 2 gene products, which comprise Polζ, play a main role in mutagenic TLS. Second, Rev1-targeted siRNA also abrogated UV-TLS, indicating that Rev1 is also indispensable to mutagenic TLS. Third, Polη-targeted siRNA also prevented TLS to a greater extent than our expectations. Forth, although siRNA to Polι had no detectable effect, that to Polκ delayed UV-TLS. To our knowledge, this is the first study reporting apparent evidence for the participation of Polκ in UV-TLS

Fundamental Characteristics of a Cylindrical Linear Pulse Motor for the Artificial Heart

A new actuator using a cylindrical linear pulse motor for the artificial heart is proposed with descriptions of the principle of operation, theoretical expression of thrust, and experimental results. The actuator has a simple configuration and its size is much smaller than the ordinary external backup facility using a pneumatic power. The actuator consists chiefly of a linear pulse motor and two rooms of sacs for the right and left ventricles. Some problems have been found to be solved before the actuator can be applied to the actual artificial heart.Article信州大学工学部紀要 56: 59-72 (1984)departmental bulletin pape

A primary aorto-duodenal fistula associated with an inflammatory abdominal aortic aneurysm: a case report.

Primary aorto-enteric fistula (PAEF)is a serious complication of abdominal aortic aneurysm(AAA). We report a patient with PAEF associated with inflammatory AAA who underwent emergent surgery. A 52-year-old male presented with recurrent hematemesis. A computer tomography scan showed a sealed rupture of the AAA adjacent to the duodenum. At surgery, a coin-sized PAEF was noted. The aorta was replaced with a Dacron graft in situ . Histological examination revealed the characteristics of an inflammatory AAA. The postoperative course was uneventful, and there has been no evidence of infection during a follow-up period of 3 years. We discuss the etiologic and surgical considerations regarding this unusual entity.</p