Use of accelerometry to investigate physical activity in dogs receiving chemotherapy

Objectives: To perform a preliminary study to assess whether single-agent palliative or adjuvant chemotherapy has an impact on objectively measured physical activity in dogs. Methods: Fifteen dogs with neoplasia (treatment group) wore ActiGraph™ accelerometers for 5-day periods before, during and after receiving single-agent adjuvant or palliative chemotherapy. Mean 5-day total physical activity and time spent in three different intensities of activity (sedentary, light-moderate and vigorous) before, during and after receiving chemotherapy were compared to a group of 15 healthy dogs (control group). Results were also compared within the treatment group across time. Results: Prior to chemotherapy, treated dogs tended to be less active than control dogs. Treatment group dogs were slightly more active at restaging than they were prior to treatment but had similar activity levels to control dogs. Marked effects of chemotherapy on physical activity were not detected. Physical activity was slightly lower in treated dogs during chemotherapy when compared to control dogs but there was a slight increase in physical activity of treated dogs during chemotherapy when compared with pretreatment recordings. There was little change in the mean 5-day total physical activity between treated dogs during chemotherapy and at restaging but a mild decrease in time spent sedentary and increase in time spent in light-moderate activity at this comparison of time points. Clinical Significance: Single-agent adjuvant or palliative chemotherapy had minimal impact on physical activity levels in dogs with neoplasia

WISeREP - An Interactive Supernova Data Repository

We have entered an era of massive data sets in astronomy. In particular, the number of supernova (SN) discoveries and classifications has substantially increased over the years from few tens to thousands per year. It is no longer the case that observations of a few prototypical events encapsulate most spectroscopic information about SNe, motivating the development of modern tools to collect, archive, organize and distribute spectra in general, and SN spectra in particular. For this reason we have developed the Weizmann Interactive Supernova data REPository - WISeREP - an SQL-based database (DB) with an interactive web-based graphical interface. The system serves as an archive of high quality SN spectra, including both historical (legacy) data as well as data that is accumulated by ongoing modern programs. The archive provides information about objects, their spectra, and related meta-data. Utilizing interactive plots, we provide a graphical interface to visualize data, perform line identification of the major relevant species, determine object redshifts, classify SNe and measure expansion velocities. Guest users may view and download spectra or other data that have been placed in the public domain. Registered users may also view and download data that are proprietary to specific programs with which they are associated. The DB currently holds >8000 spectra, of which >5000 are public; the latter include published spectra from the Palomar Transient Factory, all of the SUSPECT archive, the Caltech-Core-Collapse Program, the CfA SN spectra archive and published spectra from the UC Berkeley SNDB repository. It offers an efficient and convenient way to archive data and share it with colleagues, and we expect that data stored in this way will be easy to access, increasing its visibility, usefulness and scientific impact.Comment: To be published in PASP. WISeREP: http://www.weizmann.ac.il/astrophysics/wiserep

SN2007ax : An Extremely Faint Type Ia Supernova

We present multi-band photometric and optical spectroscopic observations of SN2007ax, the faintest and reddest Type Ia supernova (SNIa) yet observed. With M_B = -15.9 and (B-V)max = 1.2, this SN is over half a magnitude fainter at maximum light than any other SNIa. Similar to subluminous SN2005ke, SN2007ax also appears to show excess in UV emission at late time. Traditionally, Delta-m_15(B) has been used to parameterize the decline rate for SNeIa. However, the B-band transition from fast to slow decline occurs sooner than 15 days for faint SNeIa. Therefore we suggest that a more physically motivated parameter, the time of intersection of the two slopes, be used instead. Only by explaining the faintest (and the brightest) supernovae, we can thoroughly understand the physics of thermonuclear explosions. We suggest that future surveys should carefully design their cadence, depth, pointings and follow-up to find an unbiased sample of extremely faint members of this subclass of faint SNeIa.Comment: Accepted for publication in ApJ

Orphan GRB radio afterglows: Candidates and constraints on beaming

The number of orphan radio afterglows associated with gamma-ray bursts (GRBs) that should be detected by a flux limited radio survey, is calculated. It is shown that for jetted GRBs this number is smaller for smaller jet opening angle (theta), contrary to naive expectation. For a beaming factor f_b^{-1}=(theta^2/2)^{-1} = 500, roughly the value inferred by Frail et al. (2001) from analysis of afterglow light curves, we predict that between several hundreds to several thousands orphan radio afterglows should be detectable (over all sky) above 1 mJy at GHz frequencies at any given time. This orphan population is dominated by sources lying at distances of a few hundred Mpc, and having an age of ~1 yr. A search for point-like radio transients with flux densities greater than 6 mJy was conducted using the FIRST and NVSS surveys, yielding a list of 25 orphan candidates. We argue that most of the candidates are unlikely to be radio supernovae. However, the possibility that they are radio loud AGNs cannot be ruled out without further observations. Our analysis sets an upper limit for the all sky number of radio orphans, which corresponds to a lower limit f_b^{-1}>10 on the beaming factor. Rejection of all candidates found in our search would imply f_b^{-1}>100. This, and the fact that some candidates may indeed be radio afterglows, strongly motivate further observations of these transients.Comment: 18 pages, including 2 figure

Service evaluation to establish the sensitivity, specificity and additional value of broad-range 16S rDNA PCR for the diagnosis of infective endocarditis from resected endocardial material in patients from eight UK and Ireland hospitals

Infective endocarditis (IE) can be diagnosed in the clinical microbiology laboratory by culturing explanted heart valve material. We present a service evaluation that examines the sensitivity and specificity of a broad-range 16S rDNA polymerase chain reaction (PCR) assay for the detection of the causative microbe in culture-proven and culture-negative cases of IE. A clinical case-note review was performed for 151 patients, from eight UK and Ireland hospitals, whose endocardial specimens were referred to the Microbiology Laboratory at Great Ormond Street Hospital (GOSH) for broad-range 16S rDNA PCR over a 12-year period. PCR detects the causative microbe in 35/47 cases of culture-proven IE and provides an aetiological agent in 43/69 cases of culture-negative IE. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the 16S rDNA PCR assay were calculated for this series of selected samples using the clinical diagnosis of IE as the reference standard. The values obtained are as follows: sensitivity = 67 %, specificity = 91 %, PPV = 96 % and NPV = 46 %. A wide range of organisms are detected by PCR, with Streptococcus spp. detected most frequently and a relatively large number of cases of Bartonella spp. and Tropheryma whipplei IE. PCR testing of explanted heart valves is recommended in addition to culture techniques to increase diagnostic yield. The data describing the aetiological agents in a large UK and Ireland series of culture-negative IE will allow future development of the diagnostic algorithm to include real-time PCR assays targeted at specific organisms

Validity and practical utility of accelerometry for the measurement of in-hand physical activity in horses

Background: Accelerometers are valid, practical and reliable tools for the measurement of habitual physical activity (PA). Quantification of PA in horses is desirable for use in research and clinical settings. The objective of this study was to evaluate a triaxial accelerometer for objective measurement of PA in the horse by assessment of their practical utility and validity. Horses were recruited to establish both the optimal site of accelerometer attachment and questionnaire designed to explore owner acceptance. Validity and cut-off values were obtained by assessing PA at various gaits. Validation study- 20 horses wore the accelerometer while being filmed for 10 min each of rest, walking and trotting and 5 mins of canter work. Practical utility study- five horses wore accelerometers on polls and withers for 18 h; compliance and relative data losses were quantified. Results: Accelerometry output differed significantly between the four PA levels (P <0•001) for both wither and poll placement. For withers placement, ROC analyses found optimal sensitivity and specificity at a cut-off of <47 counts per minute (cpm) for rest (sensitivity 99.5 %, specificity 100 %), 967–2424 cpm for trotting (sensitivity 96.7 %, specificity 100 %) and ≥2425 cpm for cantering (sensitivity 96.0 %, specificity 97.0 %). Attachment at the poll resulted in optimal sensitivity and specificity at a cut-off of <707 counts per minute (cpm) for rest (sensitivity 97.5 %, specificity 99.6 %), 1546–2609 cpm for trotting (sensitivity 90.33 %, specificity 79.25 %) and ≥2610 cpm for cantering (sensitivity 100 %, specificity 100 %) In terms of practical utility, accelerometry was well tolerated and owner acceptance high. Conclusion: Accelerometry data correlated well with varying levels of in-hand equine activity. The use of accelerometers is a valid method for objective measurement of controlled PA in the horse