Supplementray Figures

Figure S1. The mechanistic diagram of the study. A mechanistic diagram of rosiglitazone reversing hypoxia-induced trophoblast ferroptosis via PPARγ was built by Figdraw software and Adobe Illustrator 2020. RRARγ, which binds to RXRα, could regulate lipid peroxidation and lipid synthesis by promoting Nrf2 and inhibiting SREBP1. Hypoxia intervention could inhibit RRARγ, thereby promoting lipid peroxidation and lipid synthesis to induce ferroptosis in HTR-8/Svneo cells (A). Rosiglitazone reversed hypoxia-induced ferroptosis by upregating RRARγ (B). Figure S2. GPx4 expression is independent of SREBP1. In HTR-8/SVneo cells, SREBP1 silencing did not affect GPx4 mRNA and protein expression. *P<0.05 vs the NC group, one-way ANOVA.</p