Nutrition Management in Neurogenic Dysphagia

Neurogenic dysphagia is an increasingly common problem. This chapter describes current approaches to enteral nutrition in patients with neurogenic dysphagia. We have shown the possibilities and our experience of using diet with a measured degree of density, specialized thickeners for drinks and food, ready-made enteral mixtures. We also identified patients who need a nasogastric tube or gastrostomy

РАЗВИТИЕ ТЕОРИИ УПРАВЛЕНИЯ ИННОВАЦИЯМИ НА ОСНОВЕ ОБЩЕСИСТЕМНЫХ ЗАКОНОМЕРНОСТЕЙ

The problem of a comprehension of the innovation management theory and an ability of its development on basis of system theory is set up. The authors consider features of management of socio-economic systems as open, self-organising systems with active components and give a classification of the systems’ regularities illustrating these features. The need to take into account the regularities of emergent, hierarchical order, equifinality, Ashby’s law of requisite variety, historicity and self-organization is shown.Поставлена задача осмысления состояния теории управления инновациями и возможностей ее развития на основе теории систем. Рассматриваются особенности управления социально-экономическими системами как открытыми, самоорганизующимися системами с активными элементами и приведена классификация закономерностей систем, объясняющих эти особенности. Показана необходимость учета при выборе инноваций закономерностей эммерджентности, иерархической упорядоченности, эквифинальности, закона «необходимого разнообразия» У.Р. Эшби, историчности и самоорганизации

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant

DEVELOPMENT OF INNOVATION MANAGEMENT THEORY BASED ON SYSTEM-WIDE REGULARITIES

The problem of a comprehension of the innovation management theory and an ability of its development on basis of system theory is set up. The authors consider features of management of socio-economic systems as open, self-organising systems with active components and give a classification of the systems’ regularities illustrating these features. The need to take into account the regularities of emergent, hierarchical order, equifinality, Ashby’s law of requisite variety, historicity and self-organization is shown

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant