New Stratigraphic and Palaeogeographic Results from the Palaeozoic and Early Mesozoic of the Middle Pontides (Northern Turkey) in the Azdavay, Devrekani, Küre and Inebolu Areas: Implications for the Carboniferous-Early Cretaceous Geodynamic Evolution and Some Related Remarks to the Karakaya Oceanic Rift Basin

The Küre Complex of the Middle Pontides, northern Turkey, is not a remnant of the Palaeotethys but consists of three different units with differing geological history, the Küre Ridge Unit, the Küre Ocean Unit and the Çalça Unit. The Küre Ridge Unit consists of the Serveçay Group, a pre-Permian, low-grade metamorphic Variscan oceanic sequence, and the Sirçalik Group, a Lower and Middle Triassic shallow-water sequence of North Alpine facies and event succession which disconformably overlies the Serveçay Group. Following a hiatus, the Sirçalik Group is overlain by marginal parts of the Akgöl Group with olistoliths of local origin which were derived mainly from the Sirçalik Group. The Küre Ocean Unit consists mostly of the Akgöl Group (siliciclastic turbidites and olistostromes of the Karadagtepe Formation, which is a middle Carnian to Middle Jurassic accretionary complex from the southern, active margin of the Küre Ocean, and mainly Middle Jurassic molasse type shallow-water sandstones, siltstones and shales of an unnamed formation) and of thick oceanic basalts (Ipsinler Basalt). Tectonic slices of Middle Triassic to lower Carnian ophiolites and basalts are also present. The Karadagtepe Formation contains numerous Middle Triassic exotic olistoliths and blocks of shallow-water and predominantly slope and basinal limestones, ocean-floor deep-sea sediments (shales and radiolarites), basalts and small clasts of ophiolites or ophiolitic detritus. The Çalça Unit consists of deposits from the northern, passive margin of the Küre ocean with many Pelsonian to upper Norian Hallstatt Limestones and Rhaetian-Lower Jurassic (?Middle Jurassic) deep-water shales and marls. All three units are overlain following a period of non deposition by the Upper Jurassic Bürnük Formation (red conglomerate, sandstone) and Inalti Formation (shallow-water platform carbonates). The Küre Ridge Unit was split away from the Variscan Sakarya Continent by the opening of the Karakaya oceanic rift basin during latest Permian (Dorashamian) and became a continental splinter between the Karakaya oceanic rift basin and the Küre Ocean (opened during the late Scythian). Southward subduction began in the Küre Ocean during the middle Carnian (beginning of the Karadagtepe siliciclastic turbidites), whereas at the northern passive margin the deposition of Hallstatt Limestones continued until the latest Norian. The deposition of siliciclastic turbidites and olistostromes (Diskaya Unit) began in the entire Karakaya oceanic rift basin during the middle Carnian, and ocean basin deposits (radiolarites, pelagic limestones) and slope deposits form the passive margin (e.g., Hallstatt Limestones) are no more present in the Karakaya oceanic rift basin indicating that this basin was very narrow (only a few hundreds of kilometres). During the late Norian, the Karakaya oceanic rift basin closed, whereas subduction at the southern (active margin) of the Küre ocean continued. At the northern margin of the (Upper Triassic?) Jurassic-Lower Cretaceous Beykoz-Çaglayan turbidite basin (north of the Küre Complex) the accretionary complex of an older ocean, the Late Palaeozoic Paphlagonian Ocean, was exposed that yielded clasts in the Beykoz-Çaglayan turbidite basin. Among these clasts Carboniferous to Middle Permian (Capitanian) pelagic rocks (pelagic limestones, radiolarites) could be dated. A Middle to Late Permian southward-directed subduction is assumed for the Paphlagonian Ocean. Its closure occurred either at the end of the Permian or during the Scythian

New Stratigraphic and Palaeogeographic Results from the Palaeozoic and Early Mesozoic of the Middle Pontides (Northern Turkey) in the Azdavay, Devrekani, Küre and Inebolu Areas: Implications for the Carboniferous-Early Cretaceous Geodynamic Evolution and Some Related Remarks to the Karakaya Oceanic Rift Basin

The Küre Complex of the Middle Pontides, northern Turkey, is not a remnant of the Palaeotethys but consists of three different units with differing geological history, the Küre Ridge Unit, the Küre Ocean Unit and the Çalça Unit. The Küre Ridge Unit consists of the Serveçay Group, a pre-Permian, low-grade metamorphic Variscan oceanic sequence, and the Sirçalik Group, a Lower and Middle Triassic shallow-water sequence of North Alpine facies and event succession which disconformably overlies the Serveçay Group. Following a hiatus, the Sirçalik Group is overlain by marginal parts of the Akgöl Group with olistoliths of local origin which were derived mainly from the Sirçalik Group. The Küre Ocean Unit consists mostly of the Akgöl Group (siliciclastic turbidites and olistostromes of the Karadagtepe Formation, which is a middle Carnian to Middle Jurassic accretionary complex from the southern, active margin of the Küre Ocean, and mainly Middle Jurassic molasse type shallow-water sandstones, siltstones and shales of an unnamed formation) and of thick oceanic basalts (Ipsinler Basalt). Tectonic slices of Middle Triassic to lower Carnian ophiolites and basalts are also present. The Karadagtepe Formation contains numerous Middle Triassic exotic olistoliths and blocks of shallow-water and predominantly slope and basinal limestones, ocean-floor deep-sea sediments (shales and radiolarites), basalts and small clasts of ophiolites or ophiolitic detritus. The Çalça Unit consists of deposits from the northern, passive margin of the Küre ocean with many Pelsonian to upper Norian Hallstatt Limestones and Rhaetian-Lower Jurassic (?Middle Jurassic) deep-water shales and marls. All three units are overlain following a period of non deposition by the Upper Jurassic Bürnük Formation (red conglomerate, sandstone) and Inalti Formation (shallow-water platform carbonates). The Küre Ridge Unit was split away from the Variscan Sakarya Continent by the opening of the Karakaya oceanic rift basin during latest Permian (Dorashamian) and became a continental splinter between the Karakaya oceanic rift basin and the Küre Ocean (opened during the late Scythian). Southward subduction began in the Küre Ocean during the middle Carnian (beginning of the Karadagtepe siliciclastic turbidites), whereas at the northern passive margin the deposition of Hallstatt Limestones continued until the latest Norian. The deposition of siliciclastic turbidites and olistostromes (Diskaya Unit) began in the entire Karakaya oceanic rift basin during the middle Carnian, and ocean basin deposits (radiolarites, pelagic limestones) and slope deposits form the passive margin (e.g., Hallstatt Limestones) are no more present in the Karakaya oceanic rift basin indicating that this basin was very narrow (only a few hundreds of kilometres). During the late Norian, the Karakaya oceanic rift basin closed, whereas subduction at the southern (active margin) of the Küre ocean continued. At the northern margin of the (Upper Triassic?) Jurassic-Lower Cretaceous Beykoz-Çaglayan turbidite basin (north of the Küre Complex) the accretionary complex of an older ocean, the Late Palaeozoic Paphlagonian Ocean, was exposed that yielded clasts in the Beykoz-Çaglayan turbidite basin. Among these clasts Carboniferous to Middle Permian (Capitanian) pelagic rocks (pelagic limestones, radiolarites) could be dated. A Middle to Late Permian southward-directed subduction is assumed for the Paphlagonian Ocean. Its closure occurred either at the end of the Permian or during the Scythian

Predictive value of a false-negative focused abdominal sonography for trauma (FAST) result in patients with confirmed traumatic abdominal injury

OBJECTIVE: To investigate if patients with confirmed traumatic abdominal injury and a false-negative focused abdominal sonography for trauma (FAST) examination have a more favorable prognosis than those with a true-positive FAST. METHODS: This study included 97 consecutive patients with confirmed traumatic abdominal injury (based on computed tomography [CT] and/or surgical findings) who underwent FAST. RESULTS: FAST was false-negative in 40 patients (41.2%) and true-positive in 57 patients (58.8%). Twenty-two patients (22.7%) had an unfavorable outcome (defined as the need for an interventional radiologic procedure, laparotomy, or death due to abdominal injury). Univariately, a false-negative FAST (odds ratio [OR] 0.24; p = 0.017) and a higher systolic blood pressure (OR, 0.97 per mmHg increase; p = 0.034) were significantly associated with a favorable outcome, whereas contrast extravasation on CT (OR, 7.17; p = 0.001) and shock index classification (OR, 1.89 for each higher class; p = 0.046) were significantly associated with an unfavorable outcome. Multivariately, only contrast extravasation on CT remained significantly associated with an unfavorable outcome (OR, 4.64; p = 0.016). When excluding contrast extravasation on CT from multivariate analysis, only a false-negative FAST result was predictive of a favorable outcome (OR, 0.28; p = 0.038). CONCLUSION: Trauma patients with confirmed abdominal injury and a false-negative FAST have a better outcome than those with a positive FAST. FAST may be valuable for risk stratification and prognostication in patients with a high suspicion of abdominal injury when CT has not been performed yet or when CT is not available

Patient complaints in radiology:9-year experience at a European tertiary care center

Objective To determine the frequency, nature (using standardized coding taxonomy), and temporal trends of patient complaints about the radiological service provided in a European tertiary care center. Methods This retrospective study included all written patient complaints received by the department of radiology of a European tertiary care center within a 9-year period. Results A total of 94 written patient complaints were included. Overall complaint frequency was 14.4 per 100,000 radiological procedures. Complaint frequencies per 100,000 procedures were 103.7 for interventional radiology, 13.9 for MRI, 6.9 for ultrasonography, 6.5 for CT, 4.5 for fluoroscopy, and 1.2 for conventional radiography. Interventional radiology received significantly more complaints than all other radiological procedures (p &lt;0.001), and cross-sectional imaging (CT, MRI, and ultrasonography) received significantly more complaints than conventional radiography (p &lt;0.001). Fifty-three (56.4%) complaints belonged to the clinical domain, 22 (23.4%) to the relationships domain, and 19 (20.2%) to the management domain. Quality (34.0%), safety (22.3%), timing and access (18.1%), and communication (18.1%) constituted almost all complaint categories. Patient journey (19.1%), delays (18.1%), communication breakdown (16.0%), errors in diagnosis (11.7%), quality of care (9.6%), treatment (6.4%), and staff attitudes (2.1%) constituted almost all complaint subcategories. Annual frequency of complaints decreased over time (Mann-Kendall tau = - 0.429), although not significantly (p = 0.174). Conclusion Written patient complaints directed to a department of radiology at a European tertiary care center are relatively few in number and have not shown a temporal increase. Knowledge of sources of patient dissatisfaction may help to reduce the number of patient complaints and improve patient care.</p

Machine learning in the differentiation of follicular lymphoma from diffuse large B-cell lymphoma with radiomic [F-18]FDG PET/CT features

Background One of the challenges in the management of patients with follicular lymphoma (FL) is the identification of individuals with histological transformation, most commonly into diffuse large B-cell lymphoma (DLBCL). [F-18]FDG-PET/CT is used for staging of patients with lymphoma, but visual interpretation cannot reliably discern FL from DLBCL. This study evaluated whether radiomic features extracted from clinical baseline [F-18]FDG PET/CT and analyzed by machine learning algorithms may help discriminate FL from DLBCL. Materials and methods Patients were selected based on confirmed histopathological diagnosis of primary FL (n=44) or DLBCL (n=76) and available [F-18]FDG PET/CT with EARL reconstruction parameters within 6 months of diagnosis. Radiomic features were extracted from the volume of interest on co-registered [F-18]FDG PET and CT images. Analysis of selected radiomic features was performed with machine learning classifiers based on logistic regression and tree-based ensemble classifiers (AdaBoosting, Gradient Boosting, and XG Boosting). The performance of radiomic features was compared with a SUVmax-based logistic regression model. Results From the segmented lesions, 121 FL and 227 DLBCL lesions were included for radiomic feature extraction. In total, 79 radiomic features were extracted from the SUVmap, 51 from CT, and 6 shape features. Machine learning classifier Gradient Boosting achieved the best discrimination performance using 136 radiomic features (AUC of 0.86 and accuracy of 80%). SUVmax-based logistic regression model achieved an AUC of 0.79 and an accuracy of 70%. Gradient Boosting classifier had a significantly greater AUC and accuracy compared to the SUVmax-based logistic regression (p Conclusion Machine learning analysis of radiomic features may be of diagnostic value for discriminating FL from DLBCL tumor lesions, beyond that of the SUVmax alone

Aorto-Iliac Artery Calcification Prior to Kidney Transplantation

As vascular calcification is common in kidney transplant candidates, aorto-iliac vessel imaging is performed for surgical planning. The aim of the present study was to investigate whether a novel non-contrast enhanced computed tomography-based quantification technique for aorto-iliac calcification can be used for cardiovascular risk stratification prior to kidney transplantation. In this dual-center cohort study, we measured the aorto-iliac calcium score (CaScore) of 547 patients within three years prior to transplantation (2005-2018). During a median (interquartile range) follow-up of 3.1 (1.4, 5.2) years after transplantation, 80 (14.7%) patients died, of which 32 (40.0%) died due to cardiovascular causes, and 84 (15.5%) patients had a cardiovascular event. Kaplan-Meier survival curves showed significant differences between the CaScore tertiles for cumulative overall-survival (Log-rank testp<0.0001), cardiovascular survival (p<0.0001), and cardiovascular event-free survival (p<0.001). In multivariable Cox regression, the aorto-iliac CaScore was associated with all-cause mortality (hazard ratio 1.53, 95%CI 1.14-2.06,p= 0.005), cardiovascular mortality (2.04, 1.20-3.45,p= 0.008), and cardiovascular events (1.35, 1.01-1.80,p= 0.042). These independent associations of the aorto-iliac CaScore with the outcome measures can improve the identification of patients at risk for (cardiovascular) death and those who could potentially benefit from stringent cardiovascular monitoring to improve their prognosis after transplantation

Synthesis of Glass Nanofibers Using Femtosecond Laser Radiation Under Ambient Condition

We report the unique growth of nanofibers in silica and borosilicate glass using femtosecond laser radiation at 8 MHz repetition rate and a pulse width of 214 fs in air at atmospheric pressure. The nanofibers are grown perpendicular to the substrate surface from the molten material in laser-drilled microvias where they intertwine and bundle up above the surface. The fibers are few tens of nanometers in thickness and up to several millimeters in length. Further, it is found that at some places nanoparticles are attached to the fiber surface along its length. Nanofiber growth is explained by the process of nanojets formed in the molten liquid due to pressure gradient induced from the laser pulses and subsequently drawn into fibers by the intense plasma pressure. The attachment of nanoparticles is due to the condensation of vapor in the plasma

Liver-Derived IGF-I Regulates Mean Life Span in Mice

Background: Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have increased longevity. This study investigated whether specific deficiency of liver-derived, endocrine IGF-I is of importance for life span. Methods and Findings: Serum IGF-I was reduced by approximately 80 % in mice with adult, liver-specific IGF-I inactivation (LI-IGF-I-/- mice), and body weight decreased due to reduced body fat. The mean life span of LI-IGF-I-/- mice (n = 84) increased 10 % vs. control mice (n = 137) (Cox’s test, p,0.01), mainly due to increased life span (16%) of female mice [LI-IGF-I-/- mice (n = 31): 26.761.1 vs. control (n = 67): 23.060.7 months, p,0.001]. Male LI-IGF-I-/- mice showed only a tendency for increased longevity (p = 0.10). Energy expenditure, measured as oxygen consumption during and after submaximal exercise, was increased in the LI-IGF-I-/- mice. Moreover, microarray and RT-PCR analyses showed consistent regulation of three genes (heat shock protein 1A and 1B and connective tissue growth factor) in several body organs in the LI-IGF-I-/- mice. Conclusions: Adult inactivation of liver-derived, endocrine IGF-I resulted in moderately increased mean life span. Body weight and body fat decreased in LI-IGF-I-/- mice, possibly due to increased energy expenditure during exercise. Genes earlier reported to modulate stress response and collagen aging showed consistent regulation, providing mechanisms tha

Aorto-Iliac Artery Calcification Prior to Kidney Transplantation

As vascular calcification is common in kidney transplant candidates, aorto-iliac vessel imaging is performed for surgical planning. The aim of the present study was to investigate whether a novel non-contrast enhanced computed tomography-based quantification technique for aorto-iliac calcification can be used for cardiovascular risk stratification prior to kidney transplantation. In this dual-center cohort study, we measured the aorto-iliac calcium score (CaScore) of 547 patients within three years prior to transplantation (2005–2018). During a median (interquartile range) follow-up of 3.1 (1.4, 5.2) years after transplantation, 80 (14.7%) patients died, of which 32 (40.0%) died due to cardiovascular causes, and 84 (15.5%) patients had a cardiovascular event. Kaplan-Meier survival curves showed significant differences between the CaScore tertiles for cumulative overall-survival (Log-r