Table_1_The value of chest computed tomography in evaluating lung cancer in a lobe affected by stable pulmonary tuberculosis in middle-aged and elderly patients: A preliminary study.docx

IntroductionLung cancer can be masked by coexisting stable tuberculosis lesions, which may result in delayed lung cancer diagnosis and treatment. Information about pulmonary tuberculosis patients who are at high-risk of developing lung cancer is scarce. We aimed to examine the value of chest computed tomography (CT) in evaluating lung cancer in a lobe affected by stable pulmonary tuberculosis in middle-aged and elderly patients.MethodsIn this single-centered, retrospective, observational study, we enrolled 41 middle-aged and elderly patients with pulmonary tuberculosis who developed lung cancer in the same lobe from January 30, 2011 to December 30, 2020. Comparisons of the clinical and chest CT data were made with age-matched and sex-matched control groups of patients with stable pulmonary tuberculosis but no lung cancer diagnosis (n = 38).ResultsSeventeen patients in the lung cancer group (41%) were initially misdiagnosed. Compared to lesions in the control group, lesions in the lung cancer group were significantly more likely to demonstrate the following CT features: large size, vessel convergence, lobulation, spiculation, spinous protuberance, bronchial obstruction or stenosis, vacuolation, ground-glass opacification, heterogeneous or homogeneous enhancement, and gradual increase in size. Nodular enlargement showed the best diagnostic performance in the diagnosis of lung cancer in a lobe affected by tuberculosis (area under the receiver operating characteristic curve = 0.974; P ConclusionChest CT might play an important role in early diagnosis of lung cancer in a lobe affected by tuberculosis. Regular CT re-examination is necessary in continuous controls monitoring of patients with stable pulmonary tuberculosis. The study indicates necessity of prospective study in this field.</p

<i>In situ</i> fabrication of highly organised TiO₂ nanoparticles with photo-catalytic activity in cholesterol-based organogel network

<div><p>In this paper, we developed low molecular weight gel system based on cholesterol derivative containing pyridine unit attached through β-alanine linkage, which can act as efficient gelator to form novel gel systems in organic or organic–water solvents. Spherical nanoscale anatase–TiO₂ with porous structure was obtained through the <i>in situ</i> hydrolysis in the gel tissue upon the instant addition of water followed by calcination, which had photo catalytic activity toward naphthol blue black. To the best of our knowledge, this is the first example that cholesterol-based gel tissue was employed as the template to construct TiO₂ with photo-catalytic activity.</p></div

Robust, Self-Healing, and Multistimuli-Responsive Supergelator for the Visual Recognition and Separation of Short-Chain Cycloalkanes and Alkanes

In this study, we show that a novel kind of cholesterol-based gelator NPS containing pyridyl and naphthalimide units can visually discriminate cyclohexane/cyclopentane from hexane/pentane on the basis of distinct optical differences in the gel platform, which is not observed in solution. The effect of congeneric solvents on the gel properties, such as morphology, rheology, and stimuli-responsive properties, is also studied. Intriguingly, NPS can form self-supporting, self-healing, fluorescent, and highly visible transmittance gels in cyclohexane that can selectively and visually respond to picric acid. It is deduced that NPS adopted H-type aggregation mode in cyclohexane, and the gel exhibits a strong green emission, whereas, in hexane, J-type aggregates of NPS molecules are observed with yellow emission. Correlations between the gelation properties and Hansen solubility parameters indicate that the dispersion interactions are the main factor for the selective gelation of NPS toward short-chain alkanes. A comparison of Hansen solvent parameters indicated that a similar energetic weight of the hydrogen-bonding units is the major contribution for the strong and specific interaction between NPS and cyclohexane. Furthermore, we demonstrated that the NPS xerogel can selectively solidify cyclohexane in the single-phase liquid of solvent mixtures, exhibiting fast gelation, high separation efficiency (>92%), and easy recycling of gelator and liquids. To the best of our knowledge, herein, we report the first paradigm that molecular gel formation is developed to visually discriminate and separate organic analogues of solvents with similar polarity

In Situ Growth Dynamics of Uniform Bilayer Graphene with Different Twisted Angles Following Layer-by-Layer Mode

Synthesis of large-area uniform bilayer graphene (BLG) with different twisted angles has gathered extensive interest but remains a challenge, hindered by the ubiquitous layer-plus-island growth and the uncontrollable layer rotation. Herein, using real-time surface imaging, film uniformity and stacking structures in BLG were well controlled by a two-step carbon segregation on Ni(111) films following the layer-by-layer growth mode. The aligned first graphene layers formed at 850 °C through a thermodynamics-limit process, followed by decreasing temperatures to grow the second layers, eventually enabling the extremely uniform 15°-twisted BLG at 790 °C and AB-stacked BLG at 720 °C, respectively. Essentially, the growth dynamics is perceived to determine that for the different stacking structures, nonaligned second layers are more kinetically preferable than aligned ones at relatively high temperatures, but the case reverses at low temperatures. This work conveys a fundamental dynamic understanding of the controllable integration of uniform BLG and tuning stacking structures

Switchable sol-gel transition controlled by ultrasound and body temperature

<p>Herein, we reported a new kind of naphthalimide-based derivative (<b>N1</b>), which could undergo direct sol–gel transition accelerated by ultrasound in 2-methoxyethanol. The gels are very sensitive to the body temperature in the range from 35 to 42 °C, which is the scope range of clinical thermometer. The gel-to-sol transition temperatures enhanced with the increased concentrations of the gels. The reversible gel-sol transition, together with emission intensity and morphological changes, controlled by body temperature and ultrasound could be repeated by many circles without fatigue. Therefore, the gel could be developed to an ideal sensor for detecting human body temperature.</p

In Situ Growth Dynamics of Uniform Bilayer Graphene with Different Twisted Angles Following Layer-by-Layer Mode

Synthesis of large-area uniform bilayer graphene (BLG) with different twisted angles has gathered extensive interest but remains a challenge, hindered by the ubiquitous layer-plus-island growth and the uncontrollable layer rotation. Herein, using real-time surface imaging, film uniformity and stacking structures in BLG were well controlled by a two-step carbon segregation on Ni(111) films following the layer-by-layer growth mode. The aligned first graphene layers formed at 850 °C through a thermodynamics-limit process, followed by decreasing temperatures to grow the second layers, eventually enabling the extremely uniform 15°-twisted BLG at 790 °C and AB-stacked BLG at 720 °C, respectively. Essentially, the growth dynamics is perceived to determine that for the different stacking structures, nonaligned second layers are more kinetically preferable than aligned ones at relatively high temperatures, but the case reverses at low temperatures. This work conveys a fundamental dynamic understanding of the controllable integration of uniform BLG and tuning stacking structures

Partition behavior of spiramycin in an aqueous two-phase system based on polyethylene glycol and sulfates

<p>A polymer–salt aqueous two-phase system based on polyethylene glycol and sulfates was applied to explore the partition behavior of spiramycin. Binodal curves were measured by the turbidimetric titration method. The influence of temperature, salt concentration, and pH on the distribution behavior was investigated in detail by determining the partition coefficient and extraction efficiency. As pH and salt concentration increase, the partition coefficients increase accordingly. It was found that pH displays a significant influence on the partition behavior. The partition coefficient and extraction efficiency can reach 42.46 and 97.8%, respectively, at pH 9.0 and 15.80% (w/w) salt concentration.</p

Morphology transformation between nanofibres and vesicles controlled by ultrasound and heat in tryptamine-based assembly

<p>A novel low-molecular-mass organic gelator <b>T1</b> containing tryptamine and sugar segments was designed and synthesised which can gelate alcohols accelerated by heat and sonication. Interestingly, morphology exchange between vesicles as precipitate and a three-dimensional gel network tuned by heating and ultrasound was observed. The mechanism was studied by IR, FL, X-ray diffraction. It was presented that the effect of ultrasound was to disturb the spontaneous self-assembly of <b>T1</b> molecule, and promote the long arrangement and disordered assembly of <b>T1</b> molecules into fibrous networks, thus resulting in the gelation in methanol.</p

In Situ Growth Dynamics of Uniform Bilayer Graphene with Different Twisted Angles Following Layer-by-Layer Mode

Synthesis of large-area uniform bilayer graphene (BLG) with different twisted angles has gathered extensive interest but remains a challenge, hindered by the ubiquitous layer-plus-island growth and the uncontrollable layer rotation. Herein, using real-time surface imaging, film uniformity and stacking structures in BLG were well controlled by a two-step carbon segregation on Ni(111) films following the layer-by-layer growth mode. The aligned first graphene layers formed at 850 °C through a thermodynamics-limit process, followed by decreasing temperatures to grow the second layers, eventually enabling the extremely uniform 15°-twisted BLG at 790 °C and AB-stacked BLG at 720 °C, respectively. Essentially, the growth dynamics is perceived to determine that for the different stacking structures, nonaligned second layers are more kinetically preferable than aligned ones at relatively high temperatures, but the case reverses at low temperatures. This work conveys a fundamental dynamic understanding of the controllable integration of uniform BLG and tuning stacking structures

In Situ Growth Dynamics of Uniform Bilayer Graphene with Different Twisted Angles Following Layer-by-Layer Mode

Synthesis of large-area uniform bilayer graphene (BLG) with different twisted angles has gathered extensive interest but remains a challenge, hindered by the ubiquitous layer-plus-island growth and the uncontrollable layer rotation. Herein, using real-time surface imaging, film uniformity and stacking structures in BLG were well controlled by a two-step carbon segregation on Ni(111) films following the layer-by-layer growth mode. The aligned first graphene layers formed at 850 °C through a thermodynamics-limit process, followed by decreasing temperatures to grow the second layers, eventually enabling the extremely uniform 15°-twisted BLG at 790 °C and AB-stacked BLG at 720 °C, respectively. Essentially, the growth dynamics is perceived to determine that for the different stacking structures, nonaligned second layers are more kinetically preferable than aligned ones at relatively high temperatures, but the case reverses at low temperatures. This work conveys a fundamental dynamic understanding of the controllable integration of uniform BLG and tuning stacking structures