Development of lower limb rehabilitation evaluation system based on virtual reality technology

Nowadays, with the development of the proportion of the elderly population in the world, several problems caused by the population aging gradually into people's horizons. One of the biggest problems plagued the vast majority of the elderly is hemiplegia, which leads to the vigorous development of the physical therapists. However, these traditional methods of physical therapy mainly rely on the skill of the physical therapists. In order to make up the defects of traditional methods, many research groups have developed different kinds of robots for lower limb rehabilitation training but most of them can only realize passive training which cannot adopt rehabilitation training based on the patients' individual condition effectively and they do not have a rehabilitation evaluation system to assess the real time training condition of the hemiplegic patients effectively. In order to solve the problems above, this paper proposed a lower limb rehabilitation evaluation system which is based on the virtual reality technology. This system has an easy observation of the human-computer interaction interface and the doctor is able to adjust the rehabilitation training direct at different patients in different rehabilitation stage based on this lower limb rehabilitation evaluation system. Compared with current techniques, this novel lower limb rehabilitation evaluation system is expected to have significant impacts in medical rehabilitation robot field

DataSheet1_Design and synthesis of ERα agonists: Effectively reduce lipid accumulation.docx

In recent years, the incidence of non-alcoholic fatty liver disease (NAFLD) has been increasing worldwide. Hepatic lipid deposition is a major feature of NAFLD, and insulin resistance is one of the most important causes of lipid deposition. Insulin resistance results in the disruption of lipid metabolism homeostasis characterized by increased lipogenesis and decreased lipolysis. Estrogen receptor α (ERα) has been widely reported to be closely related to lipid metabolism. Activating ERa may be a promising strategy to improve lipid metabolism. Here, we used computer-aided drug design technology to discover a highly active compound, YRL-03, which can effectively reduce lipid accumulation. Cellular experimental results showed that YRL-03 could effectively reduce lipid accumulation by targeting ERα, thereby achieving alleviation of insulin resistance. We believe this study provides meaningful guidance for future molecular development of drugs to prevent and treat NAFLD.</p

Acenaphthoimidazolylidene Gold Complex-Catalyzed Alkylsulfonylation of Boronic Acids by Potassium Metabisulfite and Alkyl Halides: A Direct and Robust Protocol To Access Sulfones

A robust acenaphthoimidazolylidene gold complex is demonstrated as a highly efficient catalyst in the direct alkylsulfonylation of boronic acids. Remarkably, a wide range of highly reactive and unreactive C-electrophiles were well-tolerated to produce various (hetero)­aryl-alkyl, aryl-alkenyl, and alkenyl-alkyl sulfones in satisfactory yields with 5 mol % catalyst loading. Along with the steric properties of NHC ligands, the high catalytic activity of this gold complex suggests that the strong σ-donation of acenaphthoimidazolylidene also played a role in promoting this challenging redox-neutral catalytic process

Side-to-Side Cold Welding for Controllable Nanogap Formation from “Dumbbell” Ultrathin Gold Nanorods

Cold welding has been regarded as a promising bottom-up nanofabrication technique because of its ability to join metallic nanostructures at room temperature with low applied stress and without introducing damage. Usually, the cold welding process can be done instantaneously for ultrathin nanowires (diameter <10 nm) in “head-to-head” joining. Here, we demonstrate that “dumbbell” shaped ultrathin gold nanorods can be cold welded in the “side-to-side” mode in a highly controllable manner and can form an extremely small nanogap via a relatively slow welding process (up to tens of minutes, allowing various functional applications). By combining in situ high-resolution transmission electron microscopic analysis and molecular dynamic simulations, we further reveal the underlying mechanism for this “side-to-side” welding process as being dominated by atom kinetics instead of thermodynamics, which provides critical insights into three-dimensional nanosystem integration as well as the building of functional nanodevices

Mitochondria-Targeting Nanoplatform with Fluorescent Carbon Dots for Long Time Imaging and Magnetic Field-Enhanced Cellular Uptake

In this study, a biocompatible nanoplatform has been constructed on the basis of magnetic mesoporous silica nanoparticles (Fe₃O₄@mSiO₂) via surface modification of triphenylphospine (TPP) and then conjugation with fluorescent carbon dots (CDs). The as-prepared Fe₃O₄@mSiO₂–TPP/CDs nanoplatform shows a very low cytotoxicity and apoptosis rate in various cell lines such as A549, CHO, HeLa, SH-SY5Y, HFF, and HMEC-1. More importantly, this nanoplatform integrates long time cell imaging, mitochondria-targeting, and magnetic field-enhanced cellular uptake functionalities into an all-in-one system. Time-dependent mitochondrial colocalization in all of the cell lines has been proved by using confocal laser scanning microscopy and flow cytometry, while the multicolored fluorescence of the Fe₃O₄@mSiO₂–TPP/CDs could remain bright and stable after coincubation for 24 h. In addition, the cellular uptake efficiency could be enhanced in a short time as a static magnetic field of 0.30 T was applied to the coincubation system of A549 and HFF cell lines. This bionanoplatform may have potential applications in targeted drug delivery for mitochondria diseases as well as early cancer diagnosis and treatment

Comparison of Two Approaches for the Attachment of a Drug to Gold Nanoparticles and Their Anticancer Activities

Drug attachment is important in drug delivery for cancer chemotherapy. The elucidation of the release mechanism and biological behavior of a drug is essential for the design of delivery systems. Here, we used a hydrazone bond or an amide bond to attach an anticancer drug, doxorubicin (Dox), to gold nanoparticles (GNPs) and compared the effects of the chemical bond on the anticancer activities of the resulting Dox-GNPs. The drug release efficiency, cytotoxicity, subcellular distribution, and cell apoptosis of hydrazone-linked HDox-GNPs and amide-linked SDox-GNPs were evaluated in several cancer cells. HDox-GNPs exhibited greater potency for drug delivery via triggered release comediated by acidic pH and glutathione (GSH) than SDox-GNPs triggered by GSH alone. Dox released from HDox-GNPs was released in lysosomes and exerted its drug activity by entering the nuclei. Dox from SDox-GNPs was mainly localized in lysosomes, significantly reducing its efficacy against cancer cells. In addition, <i>in vivo</i> studies in tumor-bearing mice demonstrated that HDox-GNPs and SDox-GNPs both accumulate in tumor tissue. However, only HDox-GNPs enhanced inhibition of subcutaneous tumor growth. This study demonstrates that HDox-GNPs display significant advantages in drug release and antitumor efficacy

Development of a rehabilitation robot for hand and wrist rehabilitation training

Up to now, the number of hemiplegia rehabilitation devices is increasing quickly along with hemiplegic patients'. But most of hand rehabilitation training just limit to the fingers flexible training of patients' affected hand. They not only ignore the importance of functional training of hand, but also wrist cooperative training during rehabilitation process. In our new research, we proposed a novel hand and wrist rehabilitation robot to achieve grasp functional training of hand except thumb and intorsion/extorsion and dorsiflexion/plantar flexion of wrist, which provides a creative hand rehabilitation way for hemiplegic patients. In this paper, we will introduce the detail design of the robot. It mainly includes two rehabilitation units - wrist rehabilitation unit and hand rehabilitation unit, which can realize separate motion or cooperate motion of hand and wrist based on patients' willingness. What's more, the torque sensor unit is purposely designed to detect feedback torque of related motion instead of available ones in the market, which makes the whole mechanical structure more compact. In a word, this novel hand and wrist rehabilitation robot will have a promising prospect

Development an arm robot to simulate the lead-pipe rigidity for medical education

Neurologic examination takes an important role in the physical examination. It requires abundant knowledge with prominent skills. Normally, the medical staffs, especially novices are trained to master the skills and accumulate experiences with several methods such as watching video, training with the simulated patient (SP), and so on. However, the drawbacks of the above methods, such as lack of multi-symptoms, lack of active interactions, etc, limit the training effects. To make up them, several kinds of medical training simulators have been developed to improve training effectiveness. However, most of these simulators just focus on mimicking the symptoms. The could not simulate the pathology of diseases. In this paper, we will propose an elbow robot named WKE-2(Waseda Kyotokagaku Elbow Robot No.2) to simulate the symptoms of motor nerve system for neurologic examination training on elbow force examination. In this paper, the mechanism of the elbow robot and physiological neurological model is described. As a sample, the performance of lead-pipe symptoms is introduced. Taking advantage of the robot, the trainee can get a full training on the examination skills and knowledge as well as the understanding of disease effection. Finally, several experiments are performed to verify the proposed robot. The results lead to the consideration that the approach is worth following in further research.

Development of an arm robot with human-like motor nerve model for neurological examination training

Development of an arm robot with human-like motor nerve model for neurological examination trainin

Visible-Light-Induced Phenoxyl Radical-based Metal–Organic Framework for Selective Photooxidation of Sulfides

Phenoxyl radicals originating from phenols through oxidation or photoinduction are relatively stable and exhibit mild oxidative activity, which endows them with the potential for photocatalysis. Herein, a stable and recyclable metal–organic framework Zr-MOF-OH constructed of a binaphthol derivative ligand has been synthesized and functions as an efficient heterogeneous photocatalyst. Zr-MOF-OH shows fairly good catalytic activity and substrate compatibility toward the selective oxidation of sulfides to sulfoxides under visible light irradiation. Such irradiation of Zr-MOF-OH converts the phenolic hydroxyl groups of the binaphthol derivative ligand to phenoxyl radicals through excited state intramolecular proton transfer, and the excited state photocatalyst triggers the single-electron oxidation of the sulfide. No reactive oxygen species are produced in the photocatalytic process, and triplet O2 directly participates in the reaction, endowing Zr-MOF-OH with wide substrate compatibility and high selectivity, which also proposes a promising pathway for the direct activation of substrates via phenoxyl radicals