Reduction of some cyclic derivatives of diphenic acid with sodium borane in alcohols

Reduction of heptamerous cyclic imides with sodium borane has been carried out for the first time by the example of some imides of diphenic acid. In this case for the first time amides of 2'-hydroxymethylxenyl-2-carboxylic acid which are potentially valued bioactive compounds were obtained. It was shown that the nature of substituent at nitrogen atom influences the reaction products yields and composition. The reduction of diphenic acid anhydride with sodium borane in simple alcohols occurs with the formation of reduction products - 7H-dibenzyl[c,e] oxepin-5-on (36...46 %) as well as products of diphenic acid alcoholysis-monoester (29...36 %). In this case the nature of alcohol influences weakly reaction products rati

Studying the influence of extractants nature in the process of thin-film vapor-phase extraction on composition, degree of extraction and form of obtained products

The technique of thin-film vapor-phase extraction of vegetable raw material has been described. By the example of birch bark the efficiency of the technique for obtaining extractive substances especially of triterpeneiod nature is show

Condition and Prospects of Development of Vaccines for Specific Prevention of Enterovirus (Nonpolio) Infection

This review summarizes the material on the development of vaccines against (nonpolio) enterovirus infection in Russia and abroad. Described the developed vaccine types, their characteristics and the results of clinical and epidemiological trials, created in China inactivated vaccines. I’is considered the possibility of creating a mucosal vaccines and vaccinal prevention strategies

КЛИНИКО-ДИАГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ ОЦЕНКИ ПОКАЗАТЕЛЕЙ СИСТЕМНОГО ВОСПАЛЕНИЯ У БОЛЬНЫХ С ВИЧ-ИНФЕКЦИЕЙ

Aim of research: to detect a diagnostic value of cumulative clinical assessment of systemic inflammation markers in monitoring a course of HIV infection. Materials and methods. The research is implemented in a sample of 162 HIV patients. The sample is divided into two groups: 1 — receiving HAART (n=88), 2 — not receiving HAART (n=74). The content of lipopolysaccharidebinding protein (LBP), procalcitonin and cytokines (TNF-a, IL-1b, IL-6, IL-8, IL-10, IFN-g, IFN-a) are detected in serum by solid-phase enzyme-linked immunosorbent assay. The number of CD4+-lymphocytes was determined by flow cytometric techniques. Results. Significantly high LBP concentration, in comparison with healthy persons’ indices, is found in both groups of the sample. The content IFN-g and IFN-a is significantly high in majority of HIV patients of the sample regardless of the therapy received. HIV patients with low content of CD4+ lymphocytes, have the indications of more severe systemic inflammation accompanied by enhanced production of anti-endotoxin proteins, and their cytokine profile is characterized by more expressed proinflammatory orientation than in HIV patients with high CD4+ lymphocytes indices. The LBP level may be treated as an indirect criterion of immune suppression intensity in HIV infection.Цель исследования: изучить диагностическую значимость определения маркеров системного воспаления при проведении мониторинга течения ВИЧ-инфекции. Материалы и методы. В исследовании участвовало 162 больных с ВИЧ-инфекцией, которые были распределены на две основные группы: 1-я — получающие АРВТ (n=88), 2-я — неполучающие АРВТ (n=74). Содержание липополисахарид-связывающего белка (LBP), прокальцитонина и цитокинов (ФНО-a, ИЛ-1b, ИЛ-6, ИЛ-8, ИЛ-10, ИНФ-g, ИНФ-a) определяли в сыворотке крови методом твердофазного иммуноферментного анализа. Количество CD4+ лимфоцитов определяли методом проточной цитометрии. Результаты. Высокая концентрация LBP отмечалась у пациентов обеих групп. Содержание ИНФ-a и ИНФ-g оказалось значительно повышенным у большинства пациентов вне зависимости от назначенной терапии. У больных с ВИЧ-инфекцией с низким содержанием CD4+ лимфоцитов, отмечаются признаки более активного системного воспаления, сопровождающегося усиленной продукцией антиэндотоксиновых белков, а цитокиновый профиль характеризуется более выраженной провоспалительной направленностью, чем у пациентов с высокими показателями CD4+ лимфоцитов. Уровень LBP можно рассматривать как косвенный критерий стадии иммуносупрессии при ВИЧ-инфекции.</p