Postoperative complications of Okabayashi's operation for carcinoma of the cervix in recent 5 years

Okabayashi's radical extensive hysterectomy is one of the excellent operations for carcinoma of the cervix. In this study on the postoperative complications during the recent 5 years, we obtained the following results. 1. In the total of 861 cases studied, the primary mortality amounts to 1.2 per cent, the incidence of the uretero-vaginal fistula 2.7 per cent, the pelvic abscess 16.8 per cent, and the lymphocyst 23.3 per cent. 2. On comparing the results with our previous ones as well as those of other investigators, it is found that satisfactory results have been obtained due to the advent of various antibiotics in recent years and also due to a marked advance made in the technics of blood and fluid administration as well as anesthesia. 3. Since the various complications have not completely been overcome and they still pose an important problem, an effort should be made toward a better postoperative care in order to prevent the complications.</p

Ab Initio Vibrational State Calculations with a Quartic Force Field: Applications to H2CO, C2H4, CH3OH, CH3CCH, and C6H6

For polyatomic molecules, n-mode coupling representations of the quartic force field (nMR-QFF) are presented, which include terms up to n normal coordinate couplings in a fourth-order polynomial potential energy function. The computational scheme to evaluate third-and fourth-order derivatives by finite differentiations of the energy is fully described. The code to generate the nMR-QFF has been implemented into GAMESS program package and interfaced with the vibrational self-consistent field (VSCF) and correlation corrected VSCF (cc-VSCF) methods. As a demonstration, fundamental frequencies have been calculated by the cc-VSCF method based on 2MR-QFF for formaldehyde, ethylene, methanol, propyne, and benzene. The applications show that 2MR-QFF is a highly accurate potential energy function, with errors of 1.0–1.9% relative to the experimental value in fundamental frequencies. This approach will help quantitative evaluations of vibrational energies of a general molecule with a reasonable computational cost

Heme breakdown and ischemia/reperfusion injury in grafted liver during living donor liver transplantation

Living donor liver transplantation (LDLT) requires ischemia/reperfusion (I/R), which can cause early graft injury. However, the detailed mechanism of I/R injury remains unknown. Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme catabolism and results in the production of iron, carbon monoxide (CO), and biliverdin IXα. Furthermore, in animals, HO-1 has a protective effect against oxidative stress associated with I/R injury. However, in humans, the molecular mechanism and clinical significance of HO-1 remain unclear. We previously demonstrated that exhaled CO levels increase during LDLT, and postulated that this may indicate I/R injury. In this study, we elucidate the origin of increased exhaled CO levels and the role of HO-1 in I/R injury during LDLT. We studied 29 LDLT donors and recipients each. For investigation of HO-1 gene expression by polymerase chain reaction and HO-1 localization by immunohistological staining, liver biopsies from the grafted liver were conducted twice, once before and once after I/R. Exhaled CO levels and HO-1 gene expression levels significantly increased after I/R. In addition, HO-1 levels significantly increased after I/R in Kupffer cells. Furthermore, we found a significant positive correlation between exhaled CO levels and HO-1 gene expression levels. These results indicated that increased heme breakdown in the grafted liver is the source of increased exhaled CO levels. We also found a significant relationship between HO-1 gene expression levels and alanine aminotransferase (ALT) levels; i.e., the higher the HO-1 gene expression levels, the higher the ALT levels. These results suggest that HO-1-mediated heme breakdown is caused by I/R during LDLT, since it is associated with increased exhaled CO levels and liver damage

A Technical Pitfall of the Smiley-Face Rod Method

The smiley-face rod method has been reported to be a successful technique for reducing slippage and repairing pars defects in lumbar spondylolisthesis. However, we encountered a patient who developed right L5 radiculopathy with muscle weakness after use of the smiley-face rod method. The patient was a 19-year-old female judo player who had undergone direct repair surgery using the smiley-face rod method for terminal-stage lumbar spondylolysis. Postoperatively, she developed paresthesia on the lateral side of the right thigh with weakness of the right tibialis anterior and extensor hallucis longus. Computed tomography showed right foraminal stenosis at L5 with the floating lamina shifted ventrally and apophyseal ring fracture. In this case, the spondylolysis fracture angle differed between the left and right sides, with the fracture line on the right side running more sagittally. As a result, the floating lamina was shifted ventrally on the right side by compression and the right L5 intervertebral foraminal space was narrowed due to the ventral shift in the floating lamina and the apophyseal ring bone fragment. The shape of the fracture line should be examined carefully before surgery to avoid this technical pitfall

Effect of the anti-parasitic compounds pyrvinium pamoate and artemisinin in enzymatic and culture assays: Data on the search for new anti-echinococcal drugs

The dataset presented herein is related to a previous research article titled “Mitochondrial Complex III in Larval Stage of Echinococcus multilocularis as a Potential Chemotherapeutic Target and in vivo Efficacy of Atovaquone Against Primary Hydatid Cysts” [1]. In this report, data were collected by screening drugs for echinococcosis. We investigated the inhibitory activities of artemisinin and pyrvinium pamoate against the mitochondrial respiratory enzymes in E. multilocularis protoscoleces. Artemisinin did not inhibit mitochondrial complexes I, II, and III. However, pyrvinium pamoate inhibited complex I at 11 μM,although complexes II and III were not inhibited. In the culture assay, E. multilocularis protoscoleces were treated with atovaquone (ATV), rotenone, praziquantel, artemisinin, and pyrvinium pamoate at a final concentration of 50 µM in different culture media. The viability of protoscoleces was compared under aerobic and anaerobic conditions via culture experiments. The survival days of E. multilocularis protoscoleces were evaluated in the drug-treated group compared with those in the non-treated group. The results of these culture assays revealed that praziquantel and artemisinin did not eliminate the protoscoleces under both aerobic and anaerobic conditions. However, a stronger elimination ability was observed with the co-administration of praziquantel or artemisinin with ATV than with ATV alone under aerobic conditions. Pyrvinium pamoate completely killed protoscoleces at 5 and 7 days under aerobic and anaerobic conditions, respectively. Pyrvinium pamoate behaved identically to rotenone, the complex I inhibitor, in the culture treatment assay.The data serve as a reference for the development of novel anti-echinococcal drugs

Full-endoscopic disc cleaning surgery

It has been reported that Modic change of the lumbar spine endplate includes three types: i.e. . edema or inflammation for type 1, fatty marrow change for type 2 and sclerotic change for type 3. Basically, type 1 Modic change may be related to the chronic low back pain. There are two kinds of the treatment for the type 1 Modic change to heal the pain : the anti-inflammatory drugs, and intra-discal injection of steroid. When the inflammatory change would be intractable, surgical intervention is needed. The gold standard for the surgical intervention is the segmental fusion of the affected level. The fusion surgery may cause the adjacent degeneration ; thus, motion preservation surgery is better, if possible. Our department started the motion preservation full-endoscopic intradiscal debridement surgery for this pathology, since some of the type 1 Modic change may be chronic discitis by P. Acnes. In this paper, we describe the first patient of type 1 Modic change who was successfully treated by the full-endoscopic intra-discal debridement and drainage under the local anesthesia. We named this procedure as transforaminal full-endoscopic disc cleaning surgery (FEDC). Finally, pathology, conservative and surgical intervention of Modic change was discussed

Direct vibrational self-consistent field method: Applications to H2O and H2CO

The vibrational self-consistent field (VSCF) and virtual configuration interaction (VCI) methods are directly combined with ab initio electronic structure calculations for evaluations of the potential energy at VSCF quadrature points. Referred to as direct VSCF and direct VCI, respectively, these methods have been applied to evaluations of anharmonic vibrational energy levels of H2O and H2CO at the second-order Mo/ller–Plesset MP2/aug-cc-pVTZ and MP2/cc-pVTZ computational levels, respectively. The purpose of the present study is to develop a direct methodology for vibrational state calculations by examining the accuracy of the results, as well as their computational costs. In addition, the accuracy and applicability of two approximate potential energy surfaces (PES), a quartic force field (QFF), and the PES determined by the modified-Shepard interpolation method (Int-PES), are investigated via comparisons of calculated energy levels of vibrational states with those derived by the direct methods. The results are analyzed in terms of three considerations: (i) truncations of higher-order intercoordinate couplings in the PES; (ii) mode–mode coupling effects; (iii) approximations in ab initioelectronic structure methods. In the direct VCI calculations, the average absolute deviations in fundamental frequencies relative to the experimental values are 9.3 cm−1(H2O) and 34.7 cm−1(H2CO). The corresponding values evaluated with approximate PESs relative to those derived by the direct method are 35.0 cm−1 (QFF) and 15.3 cm−1 (Int-PES) for H2O, and 6.3 cm−1 (QFF) and 10.3 cm−1 (Int-PES) for H2CO.The following article appeared in Journal of Chemical Physics 113 (2000: 1005, and may be found at doi:10.1063/1.481881.</p